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Listar por autor "Castejón Vega, Beatriz"
Mostrando ítems 1-10 de 10
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Artículo
Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells
Villanueva-Paz, Marina; Cordero, Mario D.; Pavón, Ana Delgado; Castejón Vega, Beatriz; Cotán, David; De la Mata, Mario; Oropesa-Ávila, Manuel; Alcocer-Gómez, Elísabet; Muntané Relat, Jordi; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio (2016-08-07)Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the ...
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Artículo
Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment
Bullon, Pedro; Castejón Vega, Beatriz; Román-Malo, Lourdes; Jimenez-Guerrero, María Paz; Cotán, David; Cordero, Mario D. (2018)Background: Cathepsin C (CatC) is a lysosomal enzyme involved in activation of serine proteases from immune and ...
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Tesis Doctoral
Autophagy dysfunctions and lysosomal permeabilization in Tay-Sachs and Sandhoff diseases
Castejón Vega, Beatriz (2020-11-20)Autophagy is an essential intracellular process involved in survival, differentiation, development and cellular homeostasis. ...
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Artículo
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
González Domínguez, Álvaro; Montañez Martínez, Raúl; Castejón Vega, Beatriz; Núñez Vasco, Jessica; Lendines Cordero, Débora; Wang, Chun; Mbalaviele, Gabriel; Navarro Pando, José Manuel; Alcocer-Gómez, Elísabet; Cordero Morales, Mario David (WILEY-BLACKWELL, 2021)Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). ...
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Artículo
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Navarro Pando, José Manuel; Alcocer-Gómez, Elísabet; Castejón Vega, Beatriz; Navarro Villarán, Elena; Condés Hervás, Mónica; Mundi Roldán, María; Muntané Relat, Jordi; Pérez Pulido, Antonio J.; Bullon, Pedro; Wang, Chun; Hoffman, Hal M.; Sanz Montero, Alberto; Mbalaviele, Gabriel; Ryffel, Bernhard; Cordero, Mario D. (American Association for the Advancement of Science, 2021)Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of ...
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Artículo
Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
Rodríguez Hernández, María A.; Cruz Ojeda, Patricia de la; López-Grueso, María José; Navarro Villarán, Elena; Requejo-Aguilar, Raquel; Castejón Vega, Beatriz; Muntané Relat, Jordi (Elsevier, 2020-03-16)Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...
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Artículo
L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation
Castejón Vega, Beatriz; Rubio Valle, Alejandro; Pérez Pulido, Antonio J.; Quiles Morales, José Luis; Lane, Jon D.; Fernández Domínguez, Beatriz; Alcocer-Gómez, Elísabet; Cordero, Mario D. (MDPI, 2021)Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that ...
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Artículo
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Marín‐Aguilar,Fabiola; Lechuga‐Vieco, Ana V.; Alcocer‐Gómez, Elísabet; Castejón Vega, Beatriz; Lucas, Javier; Bullon, Pedro; Cordero, Mario D. (Willey, 2019-09-23)While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely ...
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Artículo
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.
Marín-Aguilar, Fabiola; Lechuga‐Vieco, A.V.; Alcocer-Gómez, Elízabet; Castejón Vega, Beatriz; Lucas, Javier; Garrido, Carlos; Peralta García, Alejandro; Pérez‐Pulido, Antonio J.; Varela‐López, Alfonso; Bullon, Pedro; Cordero, Mario D. (John Wiley & Sons Ltd and The Anatomical Society, 2019-09-23)While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely ...
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Artículo
Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre
Castejón Vega, Beatriz; Battino, Maurizio; Quiles, José L.; Bullón de la Fuente, Beatriz; Cordero, Mario D.; Bullon, Pedro (MDPI, 2021)The Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) ...