idUS - Perfil del autor: Aguilera López, Andrés

Nombre	Aguilera López, Andrés
Departamento	Genética
Área de conocimiento	Genética
Categoría profesional	Catedrático de Universidad
Correo electrónico	Solicitar

Nº publicaciones

148
Nº visitas

25986
Nº descargas

30753

Tipología

Orden

Publicaciones
Tesis Doctoral Role of FACT and other chromatin-related factors in the origin of genetic instability Soler Oliva, María Eugenia; Aguilera López, Andrés; Gaillard, Hélène (2024) El mantenimiento de la integridad del genoma es un requisito indispensable para garantizar el correcto funcionamiento de ...
Tesis Doctoral Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs Guillén Mendoza, Cristina; Aguilera López, Andrés; Luna Varo, Rosa María (2023) Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del ...
Artículo Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe? Gómez González, Belén; Aguilera López, Andrés (Wiley-Blackwell, 2023) Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
Artículo The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts Bayona Feliu, Aleix; Herrera Moyano, Emilia; Badra Fajardo, Nibal; Galván Femenía, Iván; Soler Oliva, María Eugenia; Aguilera López, Andrés (Nature Research, 2023) Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
Artículo Actin nucleators safeguard replication forks by limiting nascent strand degradation Nieminuszczy, J.; Martin, P. R.; Broderick, R.; Krwawicz, J.; Kanellou, A.; Mocanu, C.; Bousgouni, V.; Smith, C.; Aguilera López, Andrés; Niedzwiedz, Wojciech (Oxford University Press, 2023) Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
Artículo DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023) Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches ...
Tesis Doctoral Global Dynamics of Topoisomerase II Activity Terrón Bautista, José; Aguilera López, Andrés; Cortés Ledesma, Felipe (2022) DNA topoisomerases are key enzymes in charge of solving topological problems that arise from essential processes of DNA ...
Artículo MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022) Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...
Artículo Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability Sarni, Dan; Barroso Ceballos, Sonia Inés; Shtrikman, Alon; Irony-Tur Sinai, Michal; Oren, Yifat S.; Aguilera López, Andrés; Kerem, Batsheva (Elsevier, 2022) DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
Artículo WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. Han, Seong Su; Wen, Kuo Kuang; García Rubio, María Luisa; Wold, Marc S.; Aguilera López, Andrés; Niedzwiedz, Wojciech; Vyas, Yatin M. (Nature Research, 2022) Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ...
Artículo A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability Cañas, Juan Carlos; García Rubio, María Luisa; García, Alicia; Antequera, Francisco; Gómez González, Belén; Aguilera López, Andrés (Genetics Society of America, 2022) The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
Tesis Doctoral DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity Marchena Cruz, Esther; Aguilera López, Andrés; Luna Varo, Rosa María (2021) La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ...
Tesis Doctoral Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs Ortega Moreno, Pedro; Aguilera López, Andrés; Gómez González, Belén (2021) La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente ...
Artículo The role of chromatin at transcription-replication conflicts as a genome safeguard Bayona Feliu, Aleix; Aguilera López, Andrés (Portland Press, 2021) DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the ...
Artículo ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair Jimeno González, Sonia; Prados Carvajal, Rosario; Fernández Ávila, María Jesús; Pinela Da Silva, Sonia Cristina; Silvestris, Domenico Alessandro; Endara Coll, Martin; Rodríguez Real, Guillermo; Domingo Prim, Judit; Mejías Navarro, Fernando; Romero Franco, Amador; Jimeno González, Silvia; Barroso, Sonia; Cesarini, Valeriana; Aguilera López, Andrés; Gallo, Angela; Visa, Neus; Huertas Sánchez, Pablo (Nature Publishing Group, 2021) The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
Artículo BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair Sessa, Gaetana; Gómez González, Belén María; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021) The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
Artículo A CDK-regulated chromatin segregase promoting chromosome replication Chacin, Erika; Bansal, Priyanka; Reusswig, Karl-Uwe; Díaz Santín, Luis M.; Ortega Moreno, Pedro; Vizjak, Petra; Gómez González, Belén; Müller-Planitz, Felix; Aguilera López, Andrés; Pfander, Boris; Cheung, Alan C. M.; Kurat, Christoph F. (Springer Nature, 2021) The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
Artículo C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability Zheleva, Angelina; Pérez de Camino Cantos, Dolores; Fernández Fernández, Nuria; García Rubio, María Luisa; Askjaer, Peter; García Muse, Tatiana; Aguilera López, Andrés (The Company of Biologists, 2021) Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is ...
Artículo The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts Bayona Feliu, Aleix; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; Aguilera López, Andrés (Springer Nature, 2021) ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ...
Artículo Harmful R-loops are prevented via different cell cycle-specific mechanisms San Martín Alonso, Marta; Soler Oliva, María Eugenia; García Rubio, María Luisa; García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2021) Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
Artículo A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021) BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
Artículo Heterogeneity of DNA damage incidence and repair in different chromatin contexts Ortega Moreno, Pedro; Gómez González, Belén María; Aguilera López, Andrés (Elsevier, 2021) It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent ...
Artículo R-Loop–Mediated ssDNA Breaks Accumulate following Short-Term Exposure to the HDAC Inhibitor Romidepsin Safari, Maryam; Litman, Thomas; Robey, Robert W.; Aguilera López, Andrés; Chakraborty, Arup R.; Reinhold, William C.; Basseville, Agnes; Petrukhin, Lubov; Scotto, Luigi; O’Connor, Owen A.; Pommier, Yves; Fojo, Antonio T.; Bates, Susan E. (American Association for Cancer Research, 2021) Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite ...
Artículo A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin Gómez González, Belén; Sessa, Gaetana; Carreira, Aura; Aguilera López, Andrés (Taylor & Francis, 2021) In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ...
Artículo Dna-rna hybrids at dsbs interfere with repair by homologous recombination Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021) DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
Capítulo de Libro Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Elsevier, 2021) The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
Artículo VID22 counteracts G-quadruplex-induced genome instability Galati, Elena; Bosio, Maria C.; Novarina, Daniele; Chiara, Matteo; Bernini, Giulia M.; Mozzarelli, Alessandro M.; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés; Carzaniga, Thomas; Todisco, Marco; Bellini, Tommaso; Nava, Giulia M.; Frige, Gianmaria; Lazzaro, Federico (Oxford University Press, 2021) Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
Artículo The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential Bayona Feliu, Aleix; Aguilera López, Andrés (Taylor & Francis, 2021) Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have ...
Artículo The human nucleoporin Tpr protects cells from RNA-mediated replication stress Kosar, Martin; Giannattasio, Michele; Piccini, Daniele; Maya Mendoza, Apolinar; García Benítez, Francisco; Bartkova, Jirina; Barroso Ceballos, Sonia Inés; Gaillard, Hélène; Martini, Emanuele; Restuccia, Umberto; Ramírez Otero, Miguel Ángel; Garre, Massimiliano; Verga, Eleonora; Andújar Sánchez, Miguel; Maynard, Scott; Hodny, Zdenek; Costanzo, Vincenzo; Kumar, Amit; Bachi, Angela; Aguilera López, Andrés; Bartek, Jiri; Foiani, Marco (Springer Nature, 2021) Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ...
Tesis Doctoral The influence of chromatin in DNA-RNA hybrid metabolism Martínez Cañas, Juan Carlos; Gómez González, Belén; Aguilera López, Andrés (2020) El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, ...
Tesis Doctoral Papel de la helicasa UAP56/DDX39B y otros factores asociados al metabolismo del ARN en la integridad del genoma Pérez Calero, Carmen; Aguilera López, Andrés (2020) Para la transmisión fidedigna de la información genética es indispensable preservar la integridad del genoma. Las células ...
Artículo Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (Shared Science Publishers OG, 2020) The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
Artículo Histone deacetylases facilitate the accurate repair of broken forks Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020) We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
Artículo UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020) Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
Capítulo de Libro The Sister-Chromatid Exchange Assay in Human Cells Tumini, Emanuela; Aguilera López, Andrés (Humana, 2020) The semiconservative nature of DNA replication allows the differential labeling of sister chromatids that isthe fundamental ...
Artículo Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020) DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
Artículo Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020) A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
Artículo TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage Giannini, Marta; Bayona Feliu, Aleix; Sproviero, Daisy; Barroso, Sonia I.; Cereda, Cristina; Aguilera López, Andrés (Public Library of Science, 2020) TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ...
Artículo Looping the (R) Loop in DSB Repair via RNA Methylation Gómez González, Belén; Aguilera López, Andrés (Elsevier, 2020) In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...
Capítulo de Libro Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection Barroso, Sonia I.; Aguilera López, Andrés (Humana, 2020) DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can ...
Artículo Homologous recombination and Mus81 promote replication completion in response to replication fork blockage Pardo, Benjamín; Moriel Carretero, María; Vicat, Thibaud; Aguilera López, Andrés; Pasero, Philippe (Wiley-Blackwell, 2020) Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...
Tesis Doctoral New factors involved in transcription-associated genome instability Mérida Cerro, José Antonio; Aguilera López, Andrés; García Rondón, Ana (2019) El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para ...
Artículo R Loops: From Physiologicalto Pathological Roles García Muse, Tatiana; Aguilera López, Andrés (Elsevier, 2019) DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional ...
Artículo The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019) Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
Tesis Doctoral New cellular elements associated with DNA:RNA hybrid homeostasis in eukaryotes San Martín Alonso, Marta; García Muse, Tatiana; Aguilera López, Andrés (2019) El mantenimiento de la integridad del genoma es esencial para el correcto funcionamiento de las funciones celulares así ...
Artículo What causes an RNA-DNA hybrid to compromise genome integrity? García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2019) Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...
Artículo Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability Zatreanu, Diana; Han, Zhong; Mitter, Richard; Tumini, Emanuela; Williams, Hannah C.; Gregersen, Lea Haarup; Dirac-Svejstrup, A. Barbara; Roma, Stefania; Stewart, Aengus; Aguilera López, Andrés; Svejstrup, Jesper (Elsevier, 2019) Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
Artículo Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019) THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
Artículo Transcription-mediated replication hindrance: a major driver of genome instability Gómez González, Belén; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019) Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
Artículo The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019) Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
Artículo Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion Aguilera López, Andrés; Gómez González, Belén; Ortega Moreno, Pedro (Nature Research, 2019) Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
Artículo The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019) R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
Artículo A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs García Muse, Tatiana; Galindo Díaz, U.; García Rubio, María Luisa; Martin, Julie S.; Polanowska, Jolanta; O'Reilly, N.; Aguilera López, Andrés; Boulton, Simon J. (Elsevier B.V., 2019) Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
Artículo The Nup84 complex coordinates the DNA damage response to warrant genome integrity Gaillard, Hélène; Santos Pereira, José María; Aguilera López, Andrés (Oxford University Press, 2019) DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
Artículo Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways Klein, Hannah L.; Bačinskaja, Giedré; Che, Jun; Cheblal, Anais; Elango, Rajula; Epshtein, Anastasiya; Fitzgerald, Devon M.; Gómez González, Belén; Khan, Sharik R.; Kumar, Sandeep Mothish; Leland, Bryan A.; Marie, Léa; Aguilera López, Andrés (Shared Science Publishers OG, 2019) Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
Tesis Doctoral Inestabilidad genética asociada a R-loops. García Benítez, Francisco; Aguilera López, Andrés; Gaillard, Hélène (2018) La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que ...
Artículo Guidelines and recommendations on yeast cell death nomenclature Carmona Gutiérrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera López, Andrés; Austriaco, N.; Ayscough, K.; Balzan, R.; Bar-Nun, S.; Madeo, F. (Shared Science Publishers, 2018) Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...
Artículo Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability Silva, Sonia; Pérez de Camino Cantos, Dolores; Aguilera López, Andrés (2018) R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ...
Artículo Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts Duch, Alba; Barroso Ceballos, Sonia Inés; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera López, Andrés (Nature Publishing Group:, 2018) Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
Artículo Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability García Rubio, María Luisa; Aguilera, Paula; Lafuente Barquero, Juan; Ruiz, José F.; Simon, Marie-Noelle; Geli, Vincent; García Rondón, Ana; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2018) R loops are an important source of genome instability, largely due to their negative impact on replication progression. ...
Artículo Epigenetic features of human telomeres Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018) Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
Capítulo de Libro Detection of DNA-RNA hybrids in vivo García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018) DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
Artículo Gene gating at nuclear pores prevents the formation of R loops Gaillard, Hélène; García Benítez, Francisco; Aguilera López, Andrés (Taylor and Francis Ltd., 2018) Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
Tesis Doctoral Papel de factores de la transcripción y la replicación del ADN en el origen de la inestabilidad genómica. Lafuente Barquero, Juan Francisco; Aguilera López, Andrés (2017) Mantener la integridad del genoma no es tarea fácil para las células. El ADN sufre constantes ataques de agentes químicos ...
Tesis Doctoral Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma Salas Armenteros, Irene; Aguilera López, Andrés; Luna Varo, Rosa María (2017) La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ...
Tesis Doctoral Papel de la cromatina en la formación de R-loops García Pichardo, Desiré; García Rondón, Ana; Aguilera López, Andrés (2017) La inestabilidad genómica es una patología celular asociada a múltiples enfermedades genéticas, incluido el cáncer (Aguilera ...
Artículo The need to regulate replication fork speed Gómez González, Belén; Aguilera López, Andrés (American Association for the Advancement of Science, 2017)
Artículo DNA-RNA hybrids: The risks of DNA breakage during transcription Aguilera López, Andrés; Gómez González, Belén (Springer Nature, 2017) Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
Artículo The Role of Replication-Associated Repair Factors on R-Loops Bhatia, Vaibhav; Herrera Moyano, Emilia; Aguilera López, Andrés; Gómez González, Belén (MDPI, 2017) The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ...
Artículo Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability Salas Armenteros, Irene; Pérez Calero, Carmen; Bayona Feliu, Aleix; Tumini, Emanuela; Luna Varo, Rosa María; Aguilera López, Andrés (Wiley-Blackwell, 2017) R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
Artículo Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability García Benítez, Francisco; Gaillard, Hélène; Aguilera López, Andrés (National Academy of Sciences, 2017) During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, ...
Artículo The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage Lafuente Barquero, Juan; Luke Glaser, Sarah; Graf, Marco; Silva, Sonia; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017) RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
Artículo Histone Mutants Separate R Loop Formation from Genome Instability Induction García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017) R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
Artículo A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017) Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
Artículo Transcription as a Threat to Genome Integrity Gaillard, Hélène; Aguilera López, Andrés (Annual Reviews Inc., 2016) Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
Artículo FANCD2 facilitates replication through common fragile sites Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016) Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
Artículo Roles of human POLD1 and POLD3 in genome stability Tumini, Emanuela; Barroso Ceballos, Sonia Inés; Pérez Calero, Carmen; Aguilera López, Andrés (Nature, 2016) DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
Artículo High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast Andersen, Sabrina L.; Zhang, Aimee; Dominska, Margaret; Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2016) The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH ...
Artículo Transcription-replication conflicts: How they occur and how they are resolved García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2016) The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
Artículo Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening Gavaldá Martín, Sandra; Santos Pereira, José María; García Rubio, María Luisa; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2016) Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ...
Artículo Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system Stuckey, Ruth; García Rodriguez, Néstor; Aguilera López, Andrés; Wellinger, Ralf Erik (National Academy of Sciences, 2015) DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication ...
Artículo The Fanconi Anemia Pathway Protects Genome Integrity from R-loops García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015) Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
Artículo Interdependence of the Rad50 hook and globular domain functions Hohl, Marcel; Kochańczyk, Tomasz; Tous, Cristina; Aguilera López, Andrés; Krężel, Artur; Petrini, John H J (Elsevier, 2015) Rad50 contains a conserved Zn2+ coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ...
Artículo A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis Open, 2015) Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ...
Artículo Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression Bravo, M.; Nicolini, F.; Starowicz, K.; Barroso Ceballos, Sonia Inés; Calés, C.; Aguilera López, Andrés; Vidal, M. (Company of Biologists Ltd, 2015) The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ...
Artículo A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions Santos Pereira, José María; García Rubio, María Luisa; González Aguilera, Cristina; Luna Varo, Rosa María; Aguilera López, Andrés (Oxford University Press, 2014) The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
Artículo The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes Herrera Moyano, Emilia; Moriel Carretero, María; Montelone, Beth A.; Aguilera López, Andrés (Public Library of Science, 2014) The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three ...
Artículo The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts Herrera Moyano, Emilia; Mergui, Xenia; García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2014) FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ...
Artículo Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability Sollier, Julie; Townsend Stork, Caroline; García Rubio, María Luisa; Aguilera López, Andrés (Elsevier, 2014) R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate ...
Artículo Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae Gaillard, Hélène; Aguilera López, Andrés (Public Library of Science, 2014) During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
Tesis Doctoral Inestabilidad genética y cambios en la cromatina en mutantes del complejo THO en mitosis y meiosis de eucariotas modelo Castellano Pozo, Maikel; Aguilera López, Andrés; García Muse, Tatiana (2013) Para el mantenimiento y el control de los procesos celulares, la integridad genética es un factor clave. Mutaciones o ...
Artículo Yeast pol4 promotes tel1-regulated chromosomal translocations Sastre Moreno, Guillermo; Aguilera López, Andrés; Ruiz Pérez, José Francisco; Pardo, Benjamín; Blanco Dávila, Luis (2013)
Artículo Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid Muñoz Galván, Sandra; Jimeno González, Sonia; Rothstein, Rodney; Aguilera López, Andrés (Public Library of Science, 2013) DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...
Artículo R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity Gavaldá Martín, Sandra; Gallardo, Mercedes; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2013) To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ...
Artículo The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability Santos Pereira, José María; Herrero, Ana B.; García Rubio, María Luisa; Marín Rodríguez, Antonio; Moreno, Sergio; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2013) Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this ...
Artículo Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013) While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
Artículo Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange Muñoz Galván, Sandra; Tous, Cristina; Blanco, Miguel G.; Schwartz, Erin K.; Ehmsen, Kirk T.; West, Stephen C.; Heyer, Wolf-Dietrich; Aguilera López, Andrés (2012) Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ...
Artículo Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous Rivera, Cristina; Aguilera López, Andrés; Carrascosa, José L.; Valpuesta, José María; Dziembowski, Andrzej (Wiley-Blackwell, 2012) The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...
Artículo Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases Pardo, Benjamín; Aguilera López, Andrés (2012)
Artículo The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development Castellano Pozo, Maikel; García Muse, Tatiana; Aguilera López, Andrés (Public Library of Science, 2012) THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing ...
Artículo Yeast Sen1 helicase protects the genome from transcription-associated instability Mischo, Hannah E.; Gómez González, Belén; Grzechnik, Pawel; García Rondón, Ana; Wei, Wu; Steinmetz, Lars; Aguilera López, Andrés; Proudfoot, Nick J. (Elsevier, 2011) Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...
Artículo Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1 Moriel Carretero, María; Tous Rivera, Cristina; Aguilera López, Andrés (National Academy of Sciences, 2011) Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform ...
Artículo Nab2 functions in the metabolism of RNA driven by polymerases II and III González Aguilera, Cristina; Tous, Cristina; Babiano González, Reyes; Cruz Díaz, Jesús de la; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2011) Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ...
Artículo Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011) One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
Artículo The Rad50 coiled-coil domain is indispensable for Mre11 complex functions Hohl, Marcel; Muñoz Galván, Sandra; Tous Rivera, Cristina; Aguilera López, Andrés; Petrini, John H. J. (Nature Publishing Group, 2011) The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ...
Artículo Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability Díaz de la Loza, María del Carmen; Gallardo Ortega, Mercedes; García Rubio, María Luisa; Izquierdo, Alicia; Herrero, Enrique; Aguilera López, Andrés; Wellinger, Ralf Erik (Oxford University Press, 2011) Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster ...
Artículo Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes García Rubio, María Luisa; Aguilera López, Andrés (2011)
Artículo The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores Bermejo, Rodrigo; Gómez González, Belén; Aguilera López, Andrés; Foiani, Marco; Capra, Thelma; Cocito, Andrea (Elsevier, 2011) Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
Artículo New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation Jimeno González, Sonia; Tous Rivera, Cristina; García Rubio, María Luisa; Ranes, Michael; González Aguilera, Cristina; Marín Rodríguez, Antonio; Aguilera López, Andrés (American Society for Microbiology, 2011) Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA ...
Artículo AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2011) Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
Artículo Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011) THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
Artículo The THO complex as a key mRNP biogenesis factor in development and cell differentiation Jimeno González, Sonia; Aguilera López, Andrés (BioMed Central, 2010) The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent ...
Tesis Doctoral Inestabilidad genética asociada a defectos en el complejo TFIIH Moriel Carretero, María; Aguilera López, Andrés (2010) Los organismos eucarióticos poseen múltiples mecanismos para preservar la integridad de su información genética. Ésta puede ...
Artículo Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair Gaillard, Hélène; Tous Rivera, Cristina; Botet, Javier; González Aguilera, Cristina; Quintero, María José; Viladevall, Laia; García Rubio, María Luisa; Rodríguez Gil, Alfonso; Marín, Antonio; Ariño, Joaquín; Revuelta, José Luis; Chávez de Diego, Sebastián; Aguilera López, Andrés (Public Library of Science, 2009) RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
Artículo The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants Gómez González, Belén; Felipe Abrio, Irene; Aguilera López, Andrés (American Society for Microbiology, 2009) Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ...
Artículo The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress Yaakov, Gilad; Duch, Alba; García Rubio, María Luisa; Clotet, Josep; Jiménez, Javier; Aguilera López, Andrés; Posas, Francesc (American Society for Cell Biology, 2009) Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular ...
Artículo Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex Luna Varo, Rosa María; González Aguilera, Cristina; Aguilera López, Andrés (Landes Bioscience, 2009) A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
Artículo Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery Boulos Faza, Marius; Kemmler, Stefan; Jimeno González, Sonia; González Aguilera, Cristina; Aguilera López, Andrés; Hurt, E (Rockefeller University Press, 2009) The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in ...
Artículo Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009) Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
Artículo R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX Aguilera López, Andrés; Gómez González, Belén (2009)
Artículo The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008) The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
Artículo CDK targets Sae2 to control DNA-end resection and homologous recombination Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008) DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
Artículo A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation Gaillard, Hélène; Aguilera López, Andrés (American Society for Cell Biology, 2008) Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
Artículo Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication Cortés Ledesma, Felipe; Tous Rivera, Cristina; Aguilera López, Andrés (Oxford University Press, 2007) Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, ...
Artículo A new connection of mRNP biogenesis and export with transcription-coupled repair Gaillard, Hélène; Wellinger, Ralf Erik; Aguilera López, Andrés (Oxford University Press, 2007) Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...
Artículo Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex Gómez González, Belén; Aguilera López, Andrés (National Academy of Sciences, 2007) Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
Artículo Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes Palancade, Benoit; Liu, Xianpeng; García Rubio, María Luisa; Aguilera López, Andrés; Zhao, Xiaolan; Doye, Valérie (American Society for Cell Biology, 2007) Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including ...
Tesis Doctoral Reparación postreplicativa de cortes de doble cadena en Saccharomyces Cerevisiae Cortés Ledesma, Felipe; Aguilera López, Andrés (2006) Entendemos como corte de doble cadena (doublé-strand break, DSB) toda interrupción en la continuidad de una molécula de ...
Artículo Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex Wellinger, Ralf Erik; Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2006) THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ...
Artículo An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006) THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
Artículo Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination Piccoli, Giacomo De; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Aguilera López, Andrés (Nature Publishing Group, 2006) DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct ...
Artículo Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants Jimeno González, Sonia; Luna Varo, Rosa María; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Microbiology, 2006) THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ...
Artículo Partial depletion of histone H4 increases homologous recombination-mediated genetic instability Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2005) DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome ...
Tesis Doctoral Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae Huertas Sánchez, Pablo; Aguilera López, Andrés (2004) La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...
Artículo Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation García Rondón, Ana; Jimeno González, Sonia; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Biochemistry and Molecular Biology Inc., 2003) THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ...
Artículo Nab2p and the Thp1p-Sac3p Complex Functionally Interact at the Interface between Transcription and mRNA Metabolism Gallardo, Mercedes; Luna Varo, Rosa María; Erdjument-Bromage, Hediye; Tempst, Paul; Aguilera López, Andrés (Elsevier, 2003) THP1 is a conserved eukaryotic gene whose null mutations confer, in yeast, transcription and genetic instability phenotypes ...
Tesis Doctoral Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente García Rondón, Ana; Aguilera López, Andrés (2003) La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ...
Tesis Doctoral Conexión entre recombinación y biogénesis del RNA: Thp1 y otras proteínas funcionalmente relacionadas Gallardo Ortega, Mercedes; Aguilera López, Andrés (2003)
Tesis Doctoral Relación entre reparación recombinación y transcripción en levaduras González Barrera, Sergio; Aguilera López, Andrés (2002)
Artículo Defective nucleotide excision repair in yeast hpr1 and tho2 mutants González Barrera, Sergio; Prado Velasco, José Félix; Verhage, Richard; Brouwer, Jaap; Aguilera López, Andrés (Oxford University Press, 2002) Nucleotide excision repair (NER) and transcription are intimately related. First, TFIIH has a dual role in transcription ...
Artículo Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae Chávez de Diego, Sebastián; García Rubio, María Luisa; Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2001) Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability ...
Tesis Doctoral Recombinación mitótica entre repeticiones invertidas de ADN en Saccharomyces cerevisiae Malagón Bautista, Francisco; Aguilera López, Andrés (2000)
Tesis Doctoral Relación de la transcripción con la recombinación entre secuencias repetidas en S. cerevisiae Piruat Palomo, José Ignacio; Aguilera López, Andrés (1998) La recombinación genética es un proceso fundamental en el metabolismo del ADN en todos los organismos vivos. Existen multitud de procesos biológicos en los que la recombinación está directamente implicada.
Artículo The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability Chávez de Diego, Sebastián; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 1997) The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have ...
Tesis Doctoral Recombinación entre secuencias repetidas e S. Cerevisiae: Análisis genético y molecular de la mutación HPR1 y de genes supresores de la misma Santos-Rosa Ruano, María Elena; Aguilera López, Andrés (1996)
Tesis Doctoral Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae Prado Velasco, José Félix; Aguilera López, Andrés (1996) Los genomios de todos los organismos están constituidos por un número variable de secuencias repetidas, que pueden llegar ...
Artículo Selection of wine yeasts for growth and fermentation in the presence of ethanol and sucrose Benítez, Tahía; Castillo, Lucas del; Aguilera López, Andrés; Conde, Jaime; Cerdá Olmedo, Enrique (American Society for Microbiology, 1983) To optimize the conversion of carbohydrates to ethanol, strains of several Saccharomyces species were examined for the ...
Tesis Doctoral Genética y fisiología de la tolerancia al etanol en "Saccharomyces cerevisiae" Aguilera López, Andrés; Benítez Fernández, Concepción Tahía; Cerdá Olmedo, Enrique (1983) En este trabajo se ha determinado el papel que juegan la herencia citoplasmática y la nuclear en la tolerancia al etanol ...