idUS - Perfil del autor: Vitorica Ferrández, Francisco Javier

Nombre	Vitorica Ferrández, Francisco Javier
Departamento	Bioquímica y Biología Molecular
Área de conocimiento	Bioquímica y Biología Molecular
Categoría profesional	Catedrático de Universidad
Correo electrónico	Solicitar

Nº publicaciones

59
Nº visitas

8764
Nº descargas

19162

Tipología

Orden

Publicaciones
Artículo Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity Borrego Écija, Sergi; Pérez Millan, Agnès; Antonell, Anna; Fort Aznar, Laura; Kaya Tilki, Elif; León Halcón, Alberto; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Boza Serrano, Antonio (Wiley, 2023) INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 ...
Artículo Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy García Bonilla, María; Ojeda Pérez, Betsaida; Shumilov, Kirill; Rodríguez-Pérez, Luis Manuel; Vitorica Ferrández, Francisco Javier; Ramírez Lorca, Reposo; Echevarría Irusta, Miriam; Páez González, Patricia; Jiménez, Antonio J. (MDPI AG, 2023) Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. ...
Artículo Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023) Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
Artículo Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease Boza Serrano, Antonio; Vrillon, Agathe; Minta, Karolina; Paulus, Agnes; Camprubí Ferrer, Lluís; García, Megg; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2022) Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
Artículo Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration-and Time-Dependent Manner Hinojosa, María Gracia; Prieto Ortega, Ana Isabel; Muñoz Castro, Clara; Sánchez Mico, María; Vitorica Ferrández, Francisco Javier; Cameán Fernández, Ana María; Jos Gallego, Ángeles Mencía (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to ...
Artículo Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease Salvadores, Natalia; Moreno González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas Gómez, Laura; Escandón, Marcela; Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Soto, Claudio; Court, Felipe A. (BMC, 2022) Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
Artículo Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis Sánchez Varo, Raquel María; Mejías Ortega, Marina; Fernández Valenzuela, Juan José; Núñez Díaz, Cristina; Cáceres Palomo, Laura; Vegas Gómez, Laura; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; García León, Juan Antonio; Moreno González, Inés; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Baglietto Vargas, David; Gutiérrez Pérez, Antonia (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...
Tesis Doctoral Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer Romero Molina, Carmen; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (2021) La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo progresivo e irreversible que conlleva un deterioro de ...
Tesis Doctoral Implicación de la disfunción glial en la evolución de la patología en pacientes de Alzheimer Muñoz Castro, Clara; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (2021) La enfermedad de Alzheimer (EA) es un proceso neurodegenerativo que cursa con un deterioro progresivo de las funciones ...
Artículo Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Fernández Valenzuela, Juan José; Castro, Vanessa de; Mejías Ortega, Marina; Gómez Arboledas, Ángela; Jiménez, Sebastián; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Frontiers Media, 2021) Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
Artículo Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021) Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
Artículo Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1 March Diaz, Rosana; Lara Ureña, Nieves; Romero Molina, Carmen; Heras Garvin, Antonio; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Springer, 2021) Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
Artículo Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases Pérez Jiménez, Mercedes María; Monje Moreno, José Manuel; Brokate Llanos, Ana María; Venegas Calerón, Mónica; Sánchez García, Alicia; Sansigre, Paula; Valladares, Amador; Esteban García, Sara; Suárez Pereira, Irene; Vitorica Ferrández, Francisco Javier; Ríos, José Julián; Artal Sanz, Marta; Carrión, Ángel Manuel; Muñoz, Manuel Jesús (Springer Nature, 2021) Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases ...
Artículo Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice Larramona Arcas, Raquel; González Arias, Candela; Perea, Gertrudis; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; García Barrera, Tamara; Gómez Ariza, José Luis; Pascua Maestro, Raquel; Ganfornina, María Dolores; Kara, Eleanna; Martínez Vicente, Marta (BMC, 2020) Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ...
Artículo Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease Sánchez Mico, María; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Romero Molina, Carmen; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier (Wiley, 2020) Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ...
Artículo Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020) Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
Artículo Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model Fernández Valenzuela, Juan José; Muñoz Castro, Clara; Jiménez Muñoz, Sebastián; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutierrez Pérez, Antonia (Nature Research, 2020) In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity ...
Artículo Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells García Bonilla, María; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020) BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial ...
Tesis Doctoral Caracterización de la respuesta y función astroglial en modelos y pacientes de la enfermedad de Alzheimer. Sánchez Mico, María; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (2019)
Artículo Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform García León, Juan Antonio; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Future Science Group, 2019) Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together ...
Artículo Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; García León, Juan Antonio; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019) Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ...
Artículo Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease Boza Serrano, Antonio; Ruíz Laza, Rocio; Sánchez Varo, Raquel María; García Revilla, Juan; Yang, Yiyi; Jiménez Ferrer, Itzia; Jiménez Muñoz, Sebastián; Roca Ceballos, María Angustias; Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Venero Recio, José Luis; Deierborg, Tomas (Springer, 2019) Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
Artículo Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018) Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
Artículo Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018) Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
Artículo Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley, 2018) Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
Patente. Invención Uso de la ectoína o sus derivados como agentes antiinflamantorios y/o antioxidantes en enfermedades causadas por la formacion de agregados proteicos Salvador de Lara, Manuel; García Valero, Rosa María; Argandoña Bertran, Montserrat; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Nieto Gutiérrez, Joaquín José; Vargas Macías, Carmen (Oficina Española de Patentes y Marcas (OEPM), 2017) Uso de la ectoína o sus derivados como agentes antiinflamatorios y/o antioxidantes en enfermedades causadas por la formación ...
Trabajo Fin de Grado Estrategias terapéuticas en la efermedad de alzheimer Riera LLull, Nieves; Vitorica Ferrández, Francisco Javier (2017)
Artículo Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017) Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
Artículo Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017) Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
Artículo Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death Fernández, Ana M.; Hervás, Rubén; Domínguez Fraile, Manuel; Garrido Navarro, Victoria; Gómez Gutiérrez, Patricia; Vega, Miguel; Torres Alemán, Ignacio; Vitorica Ferrández, Francisco Javier (IOS Press, 2016) Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
Tesis Doctoral Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (2016) Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los ...
Artículo Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016) Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
Artículo Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel María; Núñez Díaz, Cristina; Trujillo Estrada, Laura Isabel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016) The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
Artículo Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry Vitorica Ferrández, Francisco Javier; González Domínguez, Raúl; García Barrera, Tamara; Gómez Ariza, José Luis (Elsevier, 2015) The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery ...
Artículo Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Elsevier, 2015) The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological ...
Artículo Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death Carriba, Paulina; Jiménez Muñoz, Sebastián; Navarro, Victoria; Moreno González, Inés; Barneda Zahonero, Bruna; Vitorica Ferrández, Francisco Javier (Nature Publishing Group, 2015) The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ...
Artículo Metabolomic research on the role of interleukin-4 in Alzheimer’s disease González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Springer, 2015) Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral ...
Artículo Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Royal Society of Chemistry, 2015) There is growing evidence that Alzheimer's disease may be a widespread systemic disorder, so peripheral organs could be ...
Artículo Neuroinflammation in Alzheimer's Disease Heneka, Michael T.; Carson, Monica J.; El Khoury, Joseph; Landreth, Gary E.; Brosseron, Frederik; Feinstein, Douglas L.; Vitorica Ferrández, Francisco Javier; Kummer, Markus P. (Elsevier, 2015) Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment but ...
Artículo Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Elsevier, 2015) Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential ...
Artículo Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Elsevier, 2014) Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely ...
Artículo Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains Jiménez Muñoz, Sebastián; Navarro Garrido, Victoria; Moyano González, Francisco Javier; Sánchez Mico, María; Torres Canalejo, Manuel; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014) The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
Ponencia Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (2013) El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
Artículo In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013) Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
Artículo Lipopolysacharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus Ríos Sánchez, Rosa María; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; García Cuervo, Luisa; Castaño Navarro, Angélica; Gutiérrez Pérez, Antonia; Gavilán Dorronzoro, María de la Paz (2012)
Artículo Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus Sánchez Varo, Raquel María; Trujillo Estrada, Laura Isabel; Sánchez Mejías, Elisabeth; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Jiménez Muñoz, Sebastián; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Springer, 2012) Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). ...
Artículo Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012) Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
Tesis Doctoral Factores implicados en la neurodegeneración y el aumento de aβ oligomérico soluble durante el proceso de envejecimiento en un modelo ps1m146lxappsl de la enfermedad de alzheimer Torres Canalejo, Manuel; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (2011) Los Objetivos del Trabajo son: 1. Identificación de la presencia de péptido β-amiloide soluble en el medio extracelular y ...
Artículo Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density Pintado Losa, Cristina; Revilla Torres, María Elisa; Vizuete Chacón, María Luisa; García Cuervo, Luisa; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego; Castaño Navarro, Angélica (Elsevier, 2011) To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays ...
Artículo Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model Jiménez Muñoz, Sebastián; Torres Canalejo, Manuel; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Caballero, Cristina M.; Ruano Caballero, Diego; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology Inc., 2011) Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
Artículo Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition Gavilán Dorronzoro, María de la Paz; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; Jiménez Muñoz, Sebastián; Ríos Sánchez, Rosa María; Vitorica Ferrández, Francisco Javier; Castaño Navarro, Angélica; Ruano Caballero, Diego (Wiley-Blackwell, 2009) Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ...
Artículo Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic Jiménez Muñoz, Sebastián; Baglietto Vargas, David; Caballero, Cristina M.; Moreno González, Inés; Torres Canalejo, Manuel; Sánchez Varo, Raquel María; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Society for Neuroscience, 2008) Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ...
Tesis Doctoral Estudio histopatológico del hipocampo de un modelo animal transgénico PS1XAPP de la enfermedad de Alzheimer Sánchez Varo, Raquel María; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (2007)
Tesis Doctoral Caracterización de los sistemas gabaérgico y colinérgico en hipocampo de ratones transgénicos modelos de la enfermedad de Alzheimer Ramos Prieto, Blanca; Vitorica Ferrández, Francisco Javier; Ruano Caballero, Diego (2005)
Tesis Doctoral Caracterización de los sistemas gabaérgico y colinérgico en neocorteza de ratones transgénicos modelos de la enfermedad de Alzheimer Río Valencia, Juan Carlos del; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier (2005)
Tesis Doctoral Estudio del sistema gabaérgico durante el proceso normal de envejecimiento en el hipocampo de rata Vela Ríos, José; Ruano Caballero, Diego; Vitorica Ferrández, Francisco Javier (2004)
Artículo GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus Ruano Caballero, Diego; Araujo, Francisco; Revilla Torres, María Elisa; Vela, Jose; Bergis, Olivier; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology, 2000) We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ...
Artículo Molecular and pharmacological characterization of native cortical γ- aminobutyric acids receptors containing both α1 and α3 subunits Araujo, Francisco; Tan, Suan; Ruano Caballero, Diego; Schoemaker, Hans J P; Benavides, Jesús; Vitorica Ferrández, Francisco Javier (1996) We have investigated the existence, molecular composition, and benzodiazepine binding properties of native cortical α1-α3 ...
Tesis Doctoral Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento Ruano Caballero, Diego; Machado de la Quintana, Alberto; Vitorica Ferrández, Francisco Javier (1993) La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ...

Perfil del autor: Vitorica Ferrández, Francisco Javier

Datos institucionales

Estadísticas

Nº publicaciones

Nº visitas

Nº descargas

Publicaciones