Perfil del autor: Ortiz Mellet, Carmen
Datos institucionales
| Nombre | Ortiz Mellet, Carmen |
| Departamento | Química Orgánica |
| Área de conocimiento | Química Orgánica |
| Categoría profesional | Catedrática de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
103
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Nº visitas
13074
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Nº descargas
17903
| Publicaciones |
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Artículo
 Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
(Royal Society of Chemistry, 2024)
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ... |
Tesis Doctoral
 Ciclodextrinas y glicomiméticos sensibles a estímulos: aplicaciones al transporte de ácidos nucleicos y a la regulación de glicosidasas
(2024)
En las últimas décadas se ha experimentado un avance notable en el diseño y preparación sistemas capaces de participar en ... |
Artículo
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
(Elsevier, 2023)
The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ... |
Artículo
Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives
(American Chemical Society, 2023)
β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling ... |
Artículo
Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
(American Chemical Society, 2023)
Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ... |
Tesis Doctoral
Estrategias de glicosidación con sp2-iminoazúcares. Síntesis de miméticos de manooligosacáridos multivalentes y estudio de sus interacciones con lectinas de tipo-C mediante técnicas espectroscópicas, computacionales y biofísicas
(2022)
Los iminoazúcares, análogos de carbohidratos en los que se ha sustituido el oxígeno endocíclico por un átomo de nitrógeno, ... |
Tesis Doctoral
Nuevas estrategias para el estudio y tratamiento de enfermedades neurodegenerativas, la regulación del sistema inmune y el transporte de ácidos nucleicos basadas en carbohidratos
(2022)
En esta tesis se abordan diferentes aspectos de la química supramolecuar de los carbohidratos con el objetivo general de ... |
Artículo
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ... |
Artículo
A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ... |
Artículo
Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the ... |
Artículo
Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
(Wiley, 2022)
A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ... |
Artículo
Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics
(American Chemical Society, 2022)
A simple and efficient method for the stereoselective synthesis of nojirimycin α-C-glycoside derivatives has been developed ... |
Tesis Doctoral
Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros
(2021)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ... |
Artículo
Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a ... |
Artículo
Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy
(Frontiers, 2021)
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ... |
Artículo
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021)
Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ... |
Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(MDPI, 2021)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ... |
Artículo
A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors
(Royal Society of Chemistry, 2021)
A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ... |
Artículo
Cyclodextrin-Based Functional Glyconanomaterials
(MDPI, 2020)
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ... |
Artículo
Carbohydrate supramolecular chemistry: beyond the multivalent effect
(Royal Society of Chemistry, 2020)
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ... |
Artículo
Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis
(American Chemical Society, 2020)
The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ... |
Artículo
Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
(Royal Society of Chemistry, 2020)
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ... |
Artículo
Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis
(MDPI, 2020)
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ... |
Tesis Doctoral
Control de las propiedades supramoleculares de ciclodextrinas mediante la incorporación de “clips” aromáticos. Aplicación al transporte de material génico.
(2019)
Las ciclodextrinas son ciclooligosacáridos naturales formados por unidades de D-glucopiranosa unidas mediante enlaces ... |
Artículo
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
(The Society, 2019)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ... |
Patente. Invención
Procedimiento de preparación de caramelos con elevado contenido en oligosacáridos prebióticos
(Oficina Española de Patentes y Marcas (OEPM), 2019)
Procedimiento de preparación de caramelos con elevado contenido en oligosacáridos prebióticos. La presente invención ... |
Artículo
Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions
(Frontiers Media, 2019)
The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ... |
Artículo
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
(Royal Society of Chemistry, 2019)
Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ... |
Artículo
Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips
(Taylor & Francis, 2019)
The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ... |
Artículo
Novel Therapies for Orphan Diseases
(American Chemical Society, 2019)
"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ... |
Artículo
Pharmacological Chaperones for the Treatment of α-Mannosidosis
(American Chemical Society, 2019)
α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ... |
Artículo
Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids
(MDPI, 2019)
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ... |
Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(Molecular Diversity Preservation International, 2018)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ... |
Tesis Doctoral
Glicobióticos: desarrollo de caramelos con propiedades funcionales
(2017)
La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ... |
Patente. Invención
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales
(Oficina Española de Patentes y Marcas , 2017)
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende ... |
Artículo
A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin
(John Wiley & Sons, 2017)
The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ... |
Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
(Future Medicine Ltd., 2017)
Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ... |
Artículo
The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study
(2017)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ... |
Artículo
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
(Elsevier, 2017)
The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ... |
Artículo
Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells
(Frontiers Media, 2017)
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ... |
Artículo
Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
(2017)
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its ... |
Artículo
Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
(American Chemical Society, 2017)
Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ... |
Artículo
Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose
(American Chemical Society, 2017)
Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ... |
| Tesis Doctoral |
Artículo
Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry
(Royal Society of Chemistry, 2016)
For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ... |
Artículo
Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry
(Elsevier, 2016)
Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ... |
Artículo
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
(Royal Society of Chemistry, 2016)
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ... |
Artículo
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
(Royal Society of Chemistry, 2016)
Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ... |
Artículo
Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes
(Royal Society of Chemistry, 2016)
The synthesis of the first examples of multivalent C-glycosides based on C60-fullerene or β-cyclodextrin cores by way of ... |
Artículo
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
(Elsevier, 2016)
Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ... |
Artículo
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
(Royal Society of Chemistry, 2016)
Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ... |
Artículo
Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
(Royal Society of Chemistry, 2016)
The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ... |
Trabajo Fin de Máster
Iminoazúcares sp2 en inmunoterapias contra el cáncer
(2016)
En la actualidad, los tratamientos más utilizados para combatir el cáncer se basan en el uso de quimioterapia, radioterapia ... |
Tesis Doctoral
Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos
(2015)
En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ... |
Patente. Invención
Utilización de derivados bicíclicos de 1-desoxigalactonojirimicina en la preparación de un medicamento para el tratamiento de enfermedades relacionadas con beta-enzimas galactosidasas lisosómicas mutantes humanas
(Oficina Española de Patentes y Marcas (OEPM), 2015)
La presente invención se refiere a un uso de un compuesto de fórmula (I) o una de sus sales, donde R representa una cadena ... |
Artículo
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
(Royal Society of Chemistry, 2015)
The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ... |
Artículo
Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
(Elsevier, 2015)
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ... |
Artículo
Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery
(Royal Society of Chemistry, 2015)
Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ... |
Artículo
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ... |
Artículo
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
(Nature Publishing Group, 2015)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ... |
Artículo
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
(Royal Society of Chemistry, 2015)
Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ... |
Artículo
Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides
(Royal Society of Chemistry, 2015)
We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ... |
Artículo
Antileishmanial activity of sp2-iminosugar derivatives
(Royal Society of Chemistry, 2015)
A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ... |
Artículo
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ... |
Tesis Doctoral
 Preparación de nanosistemas por autoensamblaje de ciclodextrinas y calixarenos. Aplicaciones al transporte y a la liberación controlada de genes y fármacos
(2014)
En esta Tesis hemos diseñado entidades moleculares basadas en derivados de beta-ciclodextrina y calix[4]areno capaces de ... |
Patente. Invención
Uso de un compuesto de fórmula (i) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de gaucher, composición farmacéutica, un compuesto de fórmula (ib) y procedimiento de obtención.
(Oficina Española de Patentes y Marcas (OEPM), 2014)
Uso de un compuesto de fórmula (I) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de ... |
Artículo
Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers
(Royal Society of Chemistry, 2014)
Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a ... |
Artículo
Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
(American Chemical Society, 2014)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ... |
Artículo
Structural basis of pharmacological chaperoning for human β-galactosidase
(Elsevier, 2014)
GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ... |
Artículo
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ... |
Tesis Doctoral
Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1
(2013)
Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ... |
Artículo
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
(Cell Press, 2013)
Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ... |
Artículo
Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies
(Royal Society of Chemistry (Great Britain), 2013)
Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ... |
Artículo
Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions
(Royal Society of Chemistry (Great Britain), 2013)
Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ... |
Artículo
New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells
(Public Library of Science, 2013)
sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ... |
Artículo
Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo
(Elsevier, 2013)
Aim Development and evaluation of a new targeted gene delivery system by first preforming self-assembled nanocomplexes ... |
Artículo
Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
(Elsevier, 2013)
In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ... |
Patente. Invención
Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas.
(Oficina Española de Patentes y Marcas , 2011)
Derivados sp2 imnoazúcar como inhibidores de las ?-glicosidasas.Derivados glicosilados de fórmula I, donde los significados ... |
Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
(Elsevier, 2011)
Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ... |
Patente. Invención
Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares
(Oficina Española de Patentes y Marcas (OEPM), 2011)
Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares. La presente invención se refiere ... |
Patente. Invención
Compuestos potenciadores de la actividad de glicosidasas mutantes
(Oficina Española de Patentes y Marcas (OEPM), 2011)
Compuestos potenciadores de la actividad de glicosida sas mutantes, con actividad inhibidoras de enzimas gli cosidasas y ... |
Artículo
Pharmacological chaperone therapy for Gaucher disease: A patent review
(Taylor & Francis, 2011)
Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ... |
Artículo
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
(Royal Society of Chemistry (Great Britain), 2011)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ... |
Artículo
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011)
Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ... |
Tesis Doctoral
Plataformas multifuncionales basadas en ciclodextrinas: diseño de antitoxinas del ántrax y vectores de genes
(2010)
El trabajo desarrollado en esta Tesis aprovecha precisamente la faceta como plataforma nanométrica de las CDs. En ella se ... |
Artículo
(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties
(Beilstein-Institut, 2010)
Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ... |
Artículo
Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
(Elsevier, 2010)
It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ... |
Patente. Invención
Nuevos caramelos con elevado contenido en oligosacáridos prebióticos, procedimiento de preparación y utilización
(Organización Mundial de la Propiedad Intelectual (OMPI), 2009)
La presente invención se refiere a la transformación de azúcares alimentarios que contienen D-fructosa, en caramelos ... |
Patente. Invención
Nuevos derivados de ciclodextrinas selectivamente fucionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos.
(Oficina Española de Patentes y Marcas , 2008)
Nuevos derivados de coclodextrinas selectivamnet funcionalizados en su cara secundaria, procedimiento de preparación y ... |
Artículo
Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
(MDPI AG, 2008)
Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ... |
Tesis Doctoral
Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato
(2007)
Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ... |
Artículo
Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides
(2007)
The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ... |
| Tesis Doctoral |
| Tesis Doctoral |
Libro
Aspectos fisiológicos de la remolacha azucarera de siembra otoñal
(Junta de Andalucía, Consejería de Agricultura y Pesca, 2005)
Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ... |
| Tesis Doctoral |
Tesis Doctoral
Nuevos métodos de síntesis y purificación de dianhídridos de fructosa
(2004)
En el presente trabajo se han diseñado nuevos procesos de dimerización de la D-fructosa con objeto de favorecer la formación ... |
Artículo
Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors
(2004)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ... |
Tesis Doctoral
Diseño y síntesis de receptores derivados de carbohidratos: Ciclodextrinas multivalentes, podandos y ciclotrehalinas. Evaluación de su capacidad de complejación y reconocimiento por lectinas
(2001)
Las células presentan en su superficie oligosacáridos ramificados unidos de modo covalente a lípidos (glicolípidos) o ... |
Tesis Doctoral
Síntesis de pseudooligosacáridos con puentes de tipo carbamida y de glicomiméticos relacionados con las polihidroxiindolizidinas. Estudios de inhibición enzimática
(1998)
Existen sustancias naturales que presentan una gran analogía estructural con los carbohidratos y actúan como inhibidores ... |
Tesis Doctoral
Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos
(1996)
El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ... |
Tesis Doctoral
Reacción de isotiocianatos derivados de carbohidratos con compuestos α-aminocarbonilicos. Síntesis de glucosilaminotiazoles
(1984)
Se ha estudiado la reacción entre diversos isotiocianatos derivados de carbohidratos y compuestos alfa-aminocarbonílicos ... |
Artículo
sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
(Elsevier, 219)
Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ... |