Perfil del autor: López Lázaro, Miguel
Datos institucionales
| Nombre | López Lázaro, Miguel |
| Departamento | Farmacología |
| Área de conocimiento | Farmacología |
| Categoría profesional | Profesor Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
-
Nº publicaciones
59
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Nº visitas
11297
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Nº descargas
20824
| Publicaciones |
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Tesis Doctoral
 Dietas artificiales basadas en restricciones selectivas de aminoácidos para el tratamiento de cánceres metastásicos
(2023)
El cáncer mata a millones de personas cada año. Su elevada letalidad se debe a que, en el momento del diagnóstico, muchos ... |
Artículo
 Dietary Manipulation of Amino Acids for Cancer Therapy
(MDPI, 2023)
Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). ... |
Artículo
Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Current treatments for patients with metastatic triple negative breast cancer (TNBC) are generally ineffective. This ... |
Artículo
Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents-In Vitro Evaluation against Breast Cancer Cells
(MDPI, 2023)
first_pagesettingsOrder Article Reprints Open AccessArticle Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine ... |
Artículo
Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with ... |
Artículo
Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer
(MDPI, 2022)
New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests ... |
Trabajo Fin de Grado
Farmacoterapia de la leucemia mieloide crónica
(2022)
La Leucemia Mieloide Crónica (LMC) es una neoplasia de células madre hematopoyéticas clonales caracterizada por una ... |
Artículo
 Chirality influence on the cytotoxic properties of anionic chiral bis(N-heterocyclic carbene)silver complexes
(Elsevier, 2022)
Complexes Na3[Ag(NHCR)2], 2a-e and 2b’-c’, where NHCR is a N-heterocyclic carbene of the 2,2′-(1H-2λ3,3λ4-imidazole-1,3-diyl)dicarboxylate ... |
Artículo
Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) ... |
Artículo
In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and ... |
Trabajo Fin de Máster
Farmacoterapia del cáncer de tiroides
(2022)
El cáncer de tiroides es la neoplasia endocrina más común. La gravedad de esta enfermedad viene determinada por el tipo ... |
Trabajo Fin de Grado
Farmacoterapia del cáncer del intestino delgado
(2022)
Los adenocarcinomas de intestino delgado son tumores poco frecuentes del tracto gastrointestinal, de mal pronóstico, que, ... |
Artículo
pH-temperature dual-sensitive nucleolipid-containing stealth liposomes anchored with PEGylated AuNPs for triggering delivery of doxorubicin
(Elsevier, 2022)
Liposomes (Lip) are useful nanocarriers for drug delivery and cancer nanomedicine because of their ability to efficiently ... |
Artículo
Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of ... |
Trabajo Fin de Máster
Inhibidores de puntos de control inmunitario en la terapia del cáncer
(2021)
Fruto de investigaciones recientes, han surgido un grupo de fármacos contra el cáncer con un mecanismo de acción muy ... |
Artículo
Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. ... |
Artículo
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
(American Chemical Society, 2021)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ... |
Tesis Doctoral
Investigación de la selectividad anticancerosa de nuevos compuestos y estrategias contra el cáncer
(2020)
El cáncer es una enfermedad muy común y muy difícil de tratar. Las estadísticas actuales sobre el cáncer muestran que una ... |
Trabajo Fin de Grado
Farmacoterapia del cáncer de ovario epitelial. Posibles interacciones entre carboplatino y suplementos alimenticios
(2020)
El cáncer de ovario es el quinto tipo de cáncer que afecta con más frecuencia a las mujeres, siendo el más letal dentro ... |
Artículo
Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents
(MDPI, 2020)
The anti-inflammatory and anticancer properties of eight meroterpenoids isolated from the brown seaweed Cystoseira usneoides ... |
Artículo
Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain
(Taylor & Francis, 2019)
Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer ... |
Trabajo Fin de Grado
Farmcoterapia del cáncer de colon metastásico
(2019)
En España, más 37.000 personas son diagnosticadas de cáncer colorrectal al año. Es el cáncer con mayor incidencia teniendo ... |
Trabajo Fin de Grado
Farmacoterapia del cáncer renal metastásico
(2019)
El cáncer renal es uno de los 10 cánceres más comunes del mundo , represe ntando aproximadamente ... |
Artículo
Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
(Wiley, 2018)
Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ... |
Artículo
The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions
(Impact Journals, 2018)
The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ... |
Patente. Invención
Antagonistas de los receptores nk1 derivados de hidratos de carbono, metodo de obtencion y uso medico
(Oficina Española de Patentes y Marcas (OEPM), 2017)
Antagonistas de los receptores NK1 derivados de hidratos de carbono, método de obtención y uso médico. La presente invención ... |
Trabajo Fin de Grado
Biología y terapia del retinoblastoma
(2017)
El retinoblastoma es un tumor intraocular poco frecuente en la infancia que se produce en las células de la retina en ... |
Artículo
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
(Elsevier, 2017)
Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ... |
Artículo
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
(Elsevier, 2017)
A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ... |
Trabajo Fin de Grado
Prevención del cáncer mediante el control del factor de crecimiento insulínico tipo I.
(2016)
Para prevenir el cáncer de forma eficaz es importante conocer cómo se origina y cómo se desarrolla la enfermedad. Evidencias ... |
Artículo
A local mechanism by which alcohol consumption causes cancer
(2016)
Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of ... |
Artículo
Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
(MDPI AG, 2016)
Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ... |
Tesis Doctoral
Estudio del daño en el ADN inducido por compuestos polifenólicos de la dieta
(2015)
El cáncer es una enfermedad causada por la acumulación de daño en el ADN . Las células cancerosas presentan numerosas ... |
Artículo
Understanding why aspirin prevents cancer and why consuming very hot beverages and foods increases esophageal cancer risk. Controlling the division rates of stem cells is an important strategy to prevent cancer.
(2015)
Cancer is, in essence, a stem cell disease. The main biological cause of cancer is that stem cells acquire DNA alterations ... |
Artículo
Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells
(2015)
Metastasis will continue to be an incurable disease for most patients until we develop highly selective anticancer therapies. ... |
Artículo
The migration ability of stem cells can explain the existence of cancer of unknown primary site. Rethinking metastasis.
(2015)
Cancers of unknown primary site are metastatic cancers for which primary tumors are not found after detailed investigations. ... |
Artículo
Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials.
(2015)
Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. ... |
Artículo
Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
(2015)
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ... |
Artículo
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
(Oxford University Press, 2014)
Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ... |
Artículo
Evaluating the cancer therapeutic potential of cardiac glycosides
(Hindawi Publishing Corporation, 2014)
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ... |
Artículo
Induction of Apoptosis and Cell Cycle Arrest in Human Colon Carcinoma Cells by Corema album Leaves
(SAGE Publications, 2014)
The leaves of Corema album (Ericaceae), an endemic shrub which grows in Atlantic coastal areas of the Iberian Peninsula, ... |
Artículo
Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activationof the Nrf2 transcription factor and selective cytotoxic activity
(Elsevier, 2014)
Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with ... |
Tesis Doctoral
Evaluación de nuevas estrategias para el desarrollo de terapias anticancerosas selectivas
(2013)
Evaluación de nuevas estrategias para el desarrollo de terapias anticancerosas selectivas El cáncer es una enfermedad ... |
Artículo
Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase': ouabain and cáncer
(Nature Publishing Group, 2013)
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Artículo
Vitamin C and the Red Wine Polyphenol Resveratrol - but not Curcumin and the Glycolysis Inhibitors 2- Deoxyglucose, Dichloroacetate and 3-Bromopyruvate - Induce Selective Cytotoxicity against Lung Cancer Cells.
(Biomedical Publisher, 2013)
Cancer statistics show that the most commonly diagnosed cancer in the world is lung cancer, that over 50% of patients ... |
Artículo
Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of Solanum melongena (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells
(Biomedical Publisher, 2013)
Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three ... |
Artículo
The Cardiac Glycosides Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells
(Biomedical Publisher, 2013)
Cardiac glycosides are promising anticancer drugs. We have recently shown that the cardiac glycosides digitoxin, digoxin ... |
Artículo
A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells
(Georg Thieme Verlag, 2013)
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ... |
Artículo
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
(Oxford University Press, 2013)
5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ... |
Artículo
Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data
(Biomedical Publisher, 2013)
Numerous epidemiological and preclinical studies suggest that flavonoids may play an important role in the decreased risk ... |
Artículo
Chemo-protective activity and characterization of phenolic extracts from Corema album
(Elsevier, 2012)
There is currently substantial interest in the cyto-protective effects of natural compounds against oxidative stress and ... |
Artículo
Role of the Intracellular pH in the Metabolic Switch between Oxidative Phosphorylation and AerobicGlycolysis - Relevance to Cancer
(Biomedical Publisher, 2011)
Cellular energy in the form of ATP can be produced through oxidative phosphorylation and through glycolysis. Since oxidative ... |
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Artículo
Digoxin, HIF-1, and cancer
(National Academy of Sciences, 2009)
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Patente. Invención
Actividad citotóxica de la fracción de acetato de etilo de un extracto obtenido de Viscum cruciatum Sieber
(Oficina Española de Patentes y Marcas (OEPM), 2007)
Actividad citotóxica de la fracción de acetato de etilo de un extracto obtenido de Viscum cruciatum Sieber. La presente ... |
Artículo
Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.
(Natural Remedies Pvt Ltd, 2005)
To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated ... |
Artículo
Curcumin as a DNA Topoisomerase II Poison
(Taylor & Francis Open Access, 2003)
Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for ... |
Artículo
Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii
(Georg Thieme Verlag, 2003)
Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. ... |
Artículo
Flavonoids As DNA Topoisomerase I Poisons
(Taylor & Francis Open Access, 2002)
The therapeutic anticancer potential of flavonoids shown by recent research needs a greater understanding of these compounds. ... |