Perfil del autor: Jiménez Blanco, José Luis
Datos institucionales
| Nombre | Jiménez Blanco, José Luis |
| Departamento | Química Orgánica |
| Área de conocimiento | Química Orgánica |
| Categoría profesional | Profesor Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
21
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Nº visitas
2304
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Nº descargas
3717
| Publicaciones |
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Artículo
 Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
(Royal Society of Chemistry, 2024)
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ... |
Artículo
A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ... |
Artículo
Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
(Wiley, 2022)
A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ... |
Tesis Doctoral
Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros
(2021)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ... |
Artículo
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021)
Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ... |
Artículo
Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis
(MDPI, 2020)
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ... |
Artículo
Nanoparticle-delivered HIV peptides to dendritic cells a promising approach to generate a therapeutic vaccine
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Finding a functional cure for HIV-1 infection will markedly decrease the social and economic burden of this disease. In ... |
Artículo
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
(The Society, 2019)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ... |
Tesis Doctoral
Evaluación de la eficiencia de diversos alcoholes alifáticos empleados durante la molienda del cemento portland.
(2017)
El cemento es uno de los materiales de construcción más empleados en el mundo. Es un conglomerante hidráulico con excelentes ... |
Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
(Future Medicine Ltd., 2017)
Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ... |
Artículo
Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules
(Royal Society of Chemistry, 2016)
A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized ... |
Artículo
Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
(Royal Society of Chemistry, 2016)
The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ... |
Tesis Doctoral
Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos
(2015)
En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ... |
Artículo
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
(Royal Society of Chemistry, 2015)
The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ... |
Artículo
Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
(American Chemical Society, 2014)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ... |
Artículo
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ... |
Artículo
Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies
(Royal Society of Chemistry (Great Britain), 2013)
Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ... |
Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
(Elsevier, 2011)
Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ... |
Artículo
(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties
(Beilstein-Institut, 2010)
Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ... |
Artículo
Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors
(2004)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ... |
Tesis Doctoral
Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos
(1996)
El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ... |