Cell signaling networks modulate gene expression in response to internal and external stimuli. Rapid cellular adaptation ...

Las células que componen nuestro cuerpo obtienen la mayor parte de la energía que necesitan para vivir, de los alimentos ...

Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to ...

Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational ...

Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed ...

Chromatin homeostasis mediates essential processes in eukaryotes, where histone chaperones have emerged as major regulatory ...

The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...

Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary ...

More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny ...

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...

t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ...

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is ...

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...

Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the ...

Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, ...

While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ...

Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ...

Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ...

Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ...

Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...

The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed ...

Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...

Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ...

Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ...

His/Cys coordination was recently found in several c-type cytochromes, which could act as sensors, in electron transport ...

The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators”, ...

BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, ...

The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ...

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing ...

Increasing the thermal stability of immobilized proteins is a motivating goal for improving the performance of electrochemical ...

Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ...

Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ...

Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ...

Malaria is caused by Apicomplexa protozoans from the Plasmodium genus entering the bloodstream of humans and animals through ...

Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ...

Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ...

Protein production using processed cell lysates is a core technology in synthetic biology and these systems are excellent ...

The development, as well as the homeostatic control of multi-cellular organisms, requires programmed cell death processes. ...

Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the ...

Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its ...

mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby ...

TIA-1 (T-cell restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translational repression. ...

Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ...

Protein complex formation is at least a two-step process in which the formation of a final, well-defined complex entails ...

Human antigen R (HuR) is a ubiquitous 32kDa protein comprising three RNA Recognition Motifs (RRMs), whose main function ...

The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous ...

Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA ...

The rapid transfer of electrons in the photosynthetic redox chain is achieved by the formation of short-lived complexes ...

n plants, channeling of cytochrome c molecules between complexes III and IV has been purported to shuttle electrons within ...

T-cell intracellular antigen-1 (TIA-1) is a key DNA/RNA binding protein that regulates translation by sequestering target ...

Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in ...

Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich ...

En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el ...

l‐galactono‐1,4‐lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. ...

Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ...

Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood ...

Background: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding ...

Human antigen R (HuR) is a multitasking RNA binding protein involved in posttranscriptional regulation by recognizing ...

Transient complexes, with a lifetime ranging between microseconds and seconds, are essential forbiochemical reactions ...

Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ...

Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ...

Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...

T-cell intracellular antigen-1 (TIA-1) plays a pleiotropic role in cell homeostasis through the regulation of alternative ...

The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, ...

The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ...

KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding ...

Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...

The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein ...

Many fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. ...

K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein that regulates different steps of ...

The transient complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc sp. PCC 7119 has been analysed ...

The complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc has been characterized by NMR spectroscopy. ...

A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ...

Las interacciones trasitorias entre biomoléculas se han convertido en el centro de la investigación de muchas áreas de la ...

Photosystem I reduction by the soluble metalloproteins cytochrome c6 and plastocyanin, which are alternatively synthesized ...