idUS - Perfil del autor: Barroso Ceballos, Sonia Inés

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Nombre	Barroso Ceballos, Sonia Inés
Departamento	Sin Departamento Específico
Área de conocimiento	No existe área para esta sección.
Categoría profesional	TITULADO SUPERIOR
Correo electrónico	Solicitar

Nº publicaciones

19
Nº visitas

2605
Nº descargas

4973

Tipología

Orden

Publicaciones
Artículo MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022) Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...
Artículo Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability Sarni, Dan; Barroso Ceballos, Sonia Inés; Shtrikman, Alon; Irony-Tur Sinai, Michal; Oren, Yifat S.; Aguilera López, Andrés; Kerem, Batsheva (Elsevier, 2022) DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
Artículo BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair Sessa, Gaetana; Gómez González, Belén María; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021) The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
Artículo The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts Bayona Feliu, Aleix; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; Aguilera López, Andrés (Springer Nature, 2021) ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ...
Artículo A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021) BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
Artículo The human nucleoporin Tpr protects cells from RNA-mediated replication stress Kosar, Martin; Giannattasio, Michele; Piccini, Daniele; Maya Mendoza, Apolinar; García Benítez, Francisco; Bartkova, Jirina; Barroso Ceballos, Sonia Inés; Gaillard, Hélène; Martini, Emanuele; Restuccia, Umberto; Ramírez Otero, Miguel Ángel; Garre, Massimiliano; Verga, Eleonora; Andújar Sánchez, Miguel; Maynard, Scott; Hodny, Zdenek; Costanzo, Vincenzo; Kumar, Amit; Bachi, Angela; Aguilera López, Andrés; Bartek, Jiri; Foiani, Marco (Springer Nature, 2021) Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ...
Artículo UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020) Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
Artículo Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020) A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
Artículo The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019) Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
Artículo Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019) THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
Artículo The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019) R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
Artículo Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts Duch, Alba; Barroso Ceballos, Sonia Inés; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera López, Andrés (Nature Publishing Group:, 2018) Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
Artículo Epigenetic features of human telomeres Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018) Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
Capítulo de Libro Detection of DNA-RNA hybrids in vivo García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018) DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
Artículo Roles of human POLD1 and POLD3 in genome stability Tumini, Emanuela; Barroso Ceballos, Sonia Inés; Pérez Calero, Carmen; Aguilera López, Andrés (Nature, 2016) DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
Artículo The Fanconi Anemia Pathway Protects Genome Integrity from R-loops García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015) Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
Artículo Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression Bravo, M.; Nicolini, F.; Starowicz, K.; Barroso Ceballos, Sonia Inés; Calés, C.; Aguilera López, Andrés; Vidal, M. (Company of Biologists Ltd, 2015) The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ...
Artículo The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts Herrera Moyano, Emilia; Mergui, Xenia; García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2014) FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ...
Artículo Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011) THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...