Author profile: Pernia Leal, Manuel
Institutional data
Name | Pernia Leal, Manuel |
Department | Química Orgánica y Farmaceútica |
Knowledge area | Química Orgánica |
Professional category | Profesor Titular de Universidad |
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Statistics
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No. publications
21
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No. visits
2482
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No. downloads
2706
Publications |
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Article
Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
(Elsevier, 2024)
Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ... |
PhD Thesis
Derivados de d-Galactosa como antagonistas de los receptores NK1 de interés terapéutico: aproximaciones al diseño de nuevos nanosistemas teranósticos
(2023)
A pesar de los enormes esfuerzos tanto económicos como científicos invertidos en la lucha contra el cáncer, éste sigue ... |
Article
Deciphering the Parameters to Produce Highly Reproducible and Scalable Iron Oxide Nanoparticles
(Royal Society of Chemistry, 2023)
Nanomedicine has been long hailed as a game changer for treating several ailments, but its translation from bench to bedside ... |
Article
Scaling Up Magnetic Nanobead Synthesis with Improved Stability for Biomedical Applications
(American Chemical Society, 2022)
The growing interest in multifunctional nano-objects based on polymers and magnetic nanoparticles for biomedical applications ... |
Article
Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
(MDPI, 2022)
The preparation of new and functional nanostructures has received more attention in the scientific community in the past ... |
Article
Passive targeting of high-grade gliomas via the EPR effect: a closed path for metallic nanoparticles?
(Royal Society of Chemistry, 2021)
Passive tumor targeting via the enhanced permeability and retention (EPR) effect has long been considered the most effective ... |
Article
Fe₃ O₄-Au Core-Shell Nanoparticles as a Multimodal Platform for in Vivo Imaging and Focused Photothermal Therapy
(MDPI, 2021)
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au ... |
Final Degree Project
Nanomedicinas para el diagnóstico y tratamiento del glioblastoma
(2021)
El glioblastoma es considerado el tumor primario cerebral más frecuente y agresivo en adultos, siendo 15 meses la ... |
Article
PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents
(American Chemical Society, 2021)
Diagnostic imaging strongly relies on the use of contrast agents (CAs). In general terms, current CAs present undesirable ... |
Article
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
(American Chemical Society, 2021)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ... |
Article
Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization
(Taylor and Francis Group, 2020)
Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications ... |
Article
Bi-Magnetic Core-Shell CoFe2O4@MnFe2O4 Nanoparticles for In Vivo Theranostics
(MDPI, 2020)
In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, and ... |
Article
Magnetic Nanoparticles as MRI Contrast Agents
(Springer, 2020)
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic ... |
Article
Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications
(Elsevier, 2019)
Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic ... |
Article
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification
(MDPI, 2019)
Progress in the field of biocompatible SERS nanoparticles has promising prospects for biomedical applications. In this ... |
Article
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools
(American Chemical Society, 2017)
We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and ... |
Article
Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents
(Royal Society of Chemistry, 2017)
X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous ... |
Article
Synthesis of 1D-glyconanomaterials by a hybrid noncovalent–covalent functionalization of single wall carbon nanotubes: a study of their selective interactions with lectins and with live cells
(Royal Society of Chemistry, 2015)
To take full advantage of the remarkable applications of carbon nanotubes in different fields, there is a need to develop ... |
Article
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
(Springer, 2010)
We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ... |
Patent
Neoglicolipidos, sus agregados con nanotubos de carbono, procedimiento de obtencion y aplicaciones
(Oficina Española de Patentes y Marcas , 2009)
La presente invención se refiere a un glicolípido de fórmula (I) en la que R es un carbohidrato seleccionado entre un ... |
Article
Tailoring carbon nanotube surfaces with glyconanorings: New bionanomaterials with specific lectin affinity
(Royal Society of Chemistry, 2009)
Remarkably stable, water-soluble glyconanoring-coated SWCNTs were prepared by self organization and photopolymerization ... |