Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, ...

Una de las cuestiones más fascinantes de la Biología del desarrollo es entender cómo los tejidos y órganos adquieren su ...

Hoy en día, los métodos computacionales son indispensables para el análisis de imágenes biológicas. Gracias a ellos, es ...

Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell ...

Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell ...

Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in curved epithelia. Further consequences ...

Self-organization is an all-important feature of living systems that provides the means to achieve specialization and ...

Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex ...

Solid tumours and their tumour microenvironment (TME) can be considered as complex networks whose elements are in constant ...

As animals develop, the initial simple planar epithelia of the early embryos must acquire complex three-dimensional ...

Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational ...

Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, ...

In this paper, we apply persistent entropy, a novel topological statis- tic, for characterization of images of epithelial ...

In this work, we develop a method for detecting differences in the topological distribution of cells forming epithelial ...

Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin ...

As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the ...

Laser-based sources of ionizing radiation have attracted considerable attention in the last years for their broad potential ...

Natural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial ...

Morphogenesis is driven by small cell shape changes that modulate tissue organization. Apical surfaces of proliferating ...

Método para obtener información útil para el diagnóstico de enfermedades neuromusculares. Procedimiento para obtener, a ...

Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative ...

Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity ...

Diagnosis of neuromuscular diseases is based on subjective visual assessment of biopsies from patients by the pathologist ...

Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease ...

Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, ...

The motor protein non-muscle myosin II is a major driver of the movements that sculpt three dimensional organs from two ...

The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. ...

Live imaging has revolutionized the analysis of developmental biology over the last few years. The ability to track in ...

Background: Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears ...