Author profile: Docobo Pérez, Fernando
Institutional data
| Name | Docobo Pérez, Fernando |
| Department | Microbiología |
| Knowledge area | Microbiología |
| Professional category | Profesor Titular de Universidad |
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Statistics
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No. publications
27
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No. visits
3544
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No. downloads
7095
| Publications |
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Article
 Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress
(Elsevier, 2024)
In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, ... |
Article
Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
(Oxford University Press, 2024)
Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ... |
PhD Thesis
Optimisation of the therapeutic potential of fosfomycin against Enterobacteriaceae: characterisation of genetic and physiological factors related to resistance and antimicrobial activity
(2023)
Since the discovery of the first antimicrobials, bacteria with resistance mechanisms against them have been detected. The ... |
Article
Synergistic effect of SOS response and GATC methylome suppression on antibiotic stress survival in Escherichia coli
(https://journals.asm.org/doi/epdf/10.1128/aac.01392-22, 2023)
The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent ... |
Article
RecA inactivation as a strategy to reverse the heteroresistance phenomenon in clinical isolates of Escherichia coli
(Elsevier, 2023)
RecA inhibition could be an important strategy to combat antimicrobial resistance because of its key role in the SOS ... |
Article
Penicillin-Binding Protein Occupancy Dataset for 18 b-Lactams and 4 b-Lactamase Inhibitors in Neisseria gonorrhoeae
(American Society for Microbiology, 2023)
The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of ... |
Article
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial
(Oxford Academic, 2023)
Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections ... |
PhD Thesis
Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico
(2022)
En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ... |
Article
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ... |
Article
Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli
(Oxford University Press, 2022)
Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system ... |
Article
Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance
(American Society for Microbiology, 2021)
Antimicrobial resistance (particularly through extended-spectrum β-lactamase and aminoglycoside-modifying enzyme production) ... |
Article
Population pharmacokinetics of piperacillin in non-critically ill patients with bacteremia caused by enterobacteriaceae
(MDPI, 2021)
This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients with Enterobacteriaceae ... |
Article
Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress
(American Society for Microbiology, 2021)
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ... |
Article
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
(American Society for Microbiology, 2021)
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ... |
Article
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
(Frontiers Media, 2021)
Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ... |
Article
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ... |
Article
 Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
(Oxford University Press, 2020)
Objectives: To explore the effect of combining defects in DNA repair systems with the presence of fosfomycin-resistant ... |
Article
Role of low-level quinolone resistance in generating tolerance in Escherichia coli under therapeutic concentrations of ciprofloxacin
(Oxford University Press, 2020)
Background: Tolerance (including persistence) and resistance result in increased survival under antibiotic pressure. Objectives: ... |
PhD Thesis
Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.
(2018)
El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ... |
Article
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
(Elsevier, 2018)
Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ... |
Article
Quinolone Resistance Reversion by Targeting the SOS Response
(American Society for Microbiology, 2017)
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We ... |
Presentation
Population pharmacokinetics of colistin: implications for clinical use for Gram-negative pathogens
(2016)
The objective of this study was to characterize the pharmacokinetics of colistin methanesulphonate (CMS) and colistin in ... |
Article
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
(American Society for Microbiology, 2015)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ... |
Article
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
(American Society for Microbiology, 2013)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ... |
Article
Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells
(2012)
Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ... |
Article
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
(Oxford University Press, 2011)
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ... |
PhD Thesis
Tratamientos de la neumonía experimental por Staphylococcus aureus : estudios de eficacia terapéutica de cotrimoxazol, cloxacilina, linezolid y vancomicina frente a cepas S. aureus sensible y resistente a meticilina
(2009)
El objetivo general de este proyecto es comparar la actividad de cotrimoxazol, vancomicina, linezolid y cloxacilina ... |