Author profile: Vitorica Ferrández, Francisco Javier
Institutional data
Name | Vitorica Ferrández, Francisco Javier |
Department | Bioquímica y Biología Molecular |
Knowledge area | Bioquímica y Biología Molecular |
Professional category | Catedrático de Universidad |
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No. publications
60
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No. visits
10149
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No. downloads
20893
Publications |
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Article
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024)
Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ... |
Article
Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
(Wiley, 2023)
INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 ... |
Article
Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy
(MDPI AG, 2023)
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. ... |
Article
Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus
(Springer Nature, 2023)
Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ... |
Article
Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)
Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ... |
Article
Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration-and Time-Dependent Manner
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to ... |
Article
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
(BMC, 2022)
Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ... |
Article
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ... |
PhD Thesis
Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer
(2021)
La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo progresivo e irreversible que conlleva un deterioro de ... |
PhD Thesis
Implicación de la disfunción glial en la evolución de la patología en pacientes de Alzheimer
(2021)
La enfermedad de Alzheimer (EA) es un proceso neurodegenerativo que cursa con un deterioro progresivo de las funciones ... |
Article
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ... |
Article
Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ... |
Article
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
(Springer, 2021)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ... |
Article
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
(Springer Nature, 2021)
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases ... |
Article
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
(BMC, 2020)
Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ... |
Article
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
(Wiley, 2020)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ... |
Article
Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease
(MDPI, 2020)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ... |
Article
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
(Nature Research, 2020)
In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity ... |
Article
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
(BMC, 2020)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial ... |
PhD Thesis |
Article
Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
(Future Science Group, 2019)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together ... |
Article
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
(Wiley Open Access, 2019)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ... |
Article
Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ... |
Article
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
(Frontiers Media Research Foundation, 2018)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ... |
Article
Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
(Frontiers Media, 2018)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ... |
Article
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
(Wiley, 2018)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ... |
Patent. Invention
Uso de la ectoína o sus derivados como agentes antiinflamantorios y/o antioxidantes en enfermedades causadas por la formacion de agregados proteicos
(Oficina Española de Patentes y Marcas (OEPM), 2017)
Uso de la ectoína o sus derivados como agentes antiinflamatorios y/o antioxidantes en enfermedades causadas por la formación ... |
Final Degree Project |
Article
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
(Nature Research (part of Springer Nature), 2017)
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ... |
Article
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
(Public Library of Science, 2017)
Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ... |
Article
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death
(IOS Press, 2016)
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ... |
PhD Thesis
Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer
(2016)
Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los ... |
Article
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death
(IOS Press, 2016)
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ... |
Article
Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration
(Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ... |
Article
Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry
(Elsevier, 2015)
The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery ... |
Article
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
(Elsevier, 2015)
The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological ... |
Article
Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
(Nature Publishing Group, 2015)
The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ... |
Article
Metabolomic research on the role of interleukin-4 in Alzheimer’s disease
(Springer, 2015)
Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral ... |
Article
Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model
(Royal Society of Chemistry, 2015)
There is growing evidence that Alzheimer's disease may be a widespread systemic disorder, so peripheral organs could be ... |
Article
Neuroinflammation in Alzheimer's Disease
(Elsevier, 2015)
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment but ... |
Article
Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease
(Elsevier, 2015)
Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential ... |
Article
Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease
(Elsevier, 2014)
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely ... |
Article
Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
(Public Library of Science, 2014)
The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ... |
Presentation
Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer
(2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). |
Article
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)
Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ... |
Article |
Article
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). ... |
Article
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
(2012)
Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ... |
PhD Thesis
Factores implicados en la neurodegeneración y el aumento de aβ oligomérico soluble durante el proceso de envejecimiento en un modelo ps1m146lxappsl de la enfermedad de alzheimer
(2011)
Los Objetivos del Trabajo son: 1. Identificación de la presencia de péptido β-amiloide soluble en el medio extracelular y ... |
Article
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
(Elsevier, 2011)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays ... |
Article
Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ... |
Article
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ... |
Article
Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic
(Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ... |
PhD Thesis |
PhD Thesis |
PhD Thesis |
PhD Thesis |
Article
GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus
(American Society for Biochemistry and Molecular Biology, 2000)
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ... |
Article
Molecular and pharmacological characterization of native cortical γ- aminobutyric acids receptors containing both α1 and α3 subunits
(1996)
We have investigated the existence, molecular composition, and benzodiazepine binding properties of native cortical α1-α3 ... |
PhD Thesis
Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento
(1993)
La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ... |