Perfil del autor: Toledo Aral, Juan José
Datos institucionales
| Nombre | Toledo Aral, Juan José |
| Departamento | Fisiología Médica y Biofísica |
| Área de conocimiento | Fisiología |
| Categoría profesional | Catedrático de Universidad |
| Correo electrónico | Solicitar |
 |
|
Estadísticas
-
Nº publicaciones
32
-
Nº visitas
4127
-
Nº descargas
9584
| Publicaciones |
|---|
Tesis Doctoral
 Characterization of the nigrostriatal pathway in Parkinson's Disease mice models of overexpression of human alpha-synuclein and LRRK2 mutants
(2023)
Parkinson's disease (PD) is a long-term neurodegenerative disease with a complex array of symptoms and signs, involving ... |
Artículo
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ... |
Artículo
Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
(Nature Publishing Group, 2023)
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in ... |
Artículo
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
(CELL PRESS (Elsevier), 2022)
The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sym pathetic noradrenergic ... |
Artículo
Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus
(MDPI, 2021)
Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 ... |
Artículo
Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?
(Oxford University Press (OUP), 2021)
|
Artículo
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
(Springer Nature, 2021)
A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative ... |
Artículo
Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research
(Elsevier, 2020)
In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful ... |
Artículo
AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
(MDPI, 2019)
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells ... |
Artículo
Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus
(Elsevier, 2018)
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot pro cesses, and ... |
Artículo
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
(Wiley, 2018)
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded ... |
Artículo
Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy
(Wiley, 2018)
Abstract Background: The use of long-term immunosuppressive treatments on neural trans plantation has been controversial ... |
Tesis Doctoral
Xenotrasplantes de cuerpo carotideo en ratones parkinsonianos inmunodeprimidos.
(2017)
Los trasplantes intraestriatales de cuerpo carotídeo (CC) han mostrado un claro efecto beneficioso en modelos animales de ... |
Artículo
Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders
(MDPI AG, 2016)
Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has ... |
Artículo
Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.
(Wiley Online, 2016)
In models of Parkinson’s disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axonstabilizing effects on ... |
Tesis Doctoral
Desarrollo in vitro de nuevas terapias dirigidas con nanopartículas para el tratamiento del cáncer de tiroides
(2014)
A pesar de que la nanotecnología está siendo aplicada intensamente en la búsqueda de nuevos tratamientos para una amplia ... |
Patente
Procedimiento para detectar el precipitado de x-gal u otros precipitados opacos mediante microscopia confocal
(Oficina Española de Patentes y Marcas , 2013)
La presente solicitud de patente se refiere a un procedimiento para la obtención de imágenes confocales de la tinción ... |
| Artículo |
Capítulo de Libro
Carotid Body Transplants as a Therapy for Parkinson’s Disease
(The Royal Society of Chemistry, 2013)
Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, ... |
Artículo
Overexpression of aquaporin-1 in lung adenocarcinomas and pleural mesotheliomas
(2011)
Aquaporin-1 (AQP1) is the main water channel responsible for water transport through many epithelia and endothelia. The ... |
Capítulo de Libro
Neuroprotection in Parkinson’s Disease
(Royal Society of Chemistry, 2011)
|
Artículo
Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α
(2011)
Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported ... |
Tesis Doctoral
Enfermedad de parkinson y síntomas urinarios: estudio clínico y en modelos animales
(2008)
Los pacientes con Enfermedad de Parkinson (EP) presentan un mayor porcentaje de síntomas urinarios e incontinencia que la ... |
Tesis Doctoral
GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular
(2007)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares ... |
Tesis Doctoral
 Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1
(2007)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción ... |
Artículo
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
(Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, ... |
Artículo
Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric ... |
Artículo
Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation
(2005)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent ... |
Artículo
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
(2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with ... |
| Artículo |
Artículo
A Single Zinc Finger Motif in the Silencing Factor Rest Represses the Neural-Specific Type II Sodium Channel Promoter.
(PNAS, 1997)
The type II voltage-dependent sodium chan- nel is present in neuronal cells, where it mediates the ... |
Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied ... |