idUS - Perfil del autor: Smani Hajami, Tarik

Nombre	Smani Hajami, Tarik
Departamento	Fisiología Médica y Biofísica
Área de conocimiento	Fisiología
Categoría profesional	Catedrático de Universidad
Correo electrónico	Solicitar

Nº publicaciones

40
Nº visitas

4190
Nº descargas

6921

Tipología

Orden

Publicaciones
Tesis Doctoral Caracterización del papel de las poblaciones inflamatorias en el infarto revascularizado y sus implicaciones en el remodelado adverso Bevilacqua, Elisa; Smani Hajami, Tarik; Toro Estevez, Raquel Del (2023) La revascularización temprana después del infarto permite reestablecer el flujo sanguíneo a la zona infartada del corazón ...
Artículo Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation Sánchez-Collado, José; Nieto-Felipe, Joel; Jardín, Isaac; Bhardwaj, Rajesh; Berna-Erro, Alejandro; Salido, Ginés M.; Smani Hajami, Tarik; Rosado, Juan A. (MDPI, 2022) N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with ...
Tesis Doctoral Evaluación de la imagen multimodal para la impresión 3D en cardiopatías congénitas: docencia, aplicaciones clínicas y perspectivas futuras Valverde Pérez, Israel; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (2022) Las cardiopatías congénitas son las malformaciones presentes al nacimiento más frecuentes, y tienen un impacto muy ...
Tesis Doctoral Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF Galeano Otero, Isabel María; Smani Hajami, Tarik (2022) La angiogénesis se define como el proceso llevado a cabo por las células endoteliales (CE) por el cual se forman nuevos ...
Artículo Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning Mayoral González, Isabel; Bevilacqua, Elisa; Gómez, Gorka; Hmadcha, Abdelkrim; González-Loscertales, Ignacio; Reina Romo, Esther; Sotelo, Julio; Domínguez, Antonia; Pérez Alcántara, Pedro; Smani, Younes; González Puertas, Patricia Isabel; Méndez, Ana; Uribe, Sergio; Smani Hajami, Tarik; Ordóñez, Antonio; Valverde Pérez, Israel (Elsevier, 2022) Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, ...
Artículo Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells Sánchez Collado, José; López, José J.; Jardín, Isaac; Berna-Erro, Alejandro; Camello, Pedro J.; Cantonero, Carlos; Smani Hajami, Tarik; Salido, Gines M.; Rosado, Juan A. (Springer, 2022) The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel ...
Artículo Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation Mayoral-González, Isabel; Calderón Sánchez, Eva M.; Galeano-Otero, Isabel; Martín Bórnez, Marta; Gutiérrez Carretero, Encarnación; Fernández Velasco, María; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (CELL PRESS (Elsevier), 2022) Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, ...
Artículo Predicted Value of MicroRNAs, Vascular Endothelial Growth Factor, and Intermediate Monocytes in the Left Adverse Ventricular Remodeling in Revascularized ST-Segment Elevation Myocardial Infarction Patients Toro Estévez, Raquel del; Galeano-Otero, Isabel; Bevilacqua, , Elisa; Guerrero-Márquez, Francisco; Falcón Boyano, Debóra; Barón-Esquivias, Gonzalo; Smani Hajami, Tarik; Ordóñez-Fernández, Antonio (Frontiers Media S.A, 2022) Background: Primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction ...
Artículo Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells Sánchez Collado, José; Lopez, Jose J.; Cantonero, Carlos; Jardin, Isaac; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021) Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity ...
Artículo Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19 Hmadcha, Abdelkrim; Soria, Bernat; Zhao, Robert C.; Smani Hajami, Tarik; Valverde Pérez, Israel (Frontiers Media, 2021) We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of ...
Artículo Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling Calderón Sánchez, Eva María; Falcón Boyano, Débora; Martín Bórnez, Marta; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (MDPI, 2021) Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent ...
Artículo Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease Gruszczynska-Biegala, Joanna; Martín-Romero, Francisco Javier; Smani Hajami, Tarik; Secondo, Agnese (Frontiers Media, 2021) Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This ...
Tesis Doctoral Remodelado ventricular adverso tras reperfusión aguda. Efecto cardioprotector de la Urocortina-2 Mayoral González, Isabel; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (2021) Las enfermedades cardiovasculares son la principal causa de muerte en el mundo desarrollado, siendo tres de ellas las más ...
Artículo Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells López, Jose J.; Siegfried, Geraldine; Cantonero, Carlos; Soulet, Fabienne; Descarpentrie, Jean; Smani Hajami, Tarik (MDPI, 2021) Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation ...
Artículo miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis Gutiérrez Carretero, Encarnación; Mayoral González, Isabel; Morón, Francisco Jesús; Fernandez-Quero, Mónica; Domínguez Rodríguez, Alejandro; Ordoñez, Antonio; Smani Hajami, Tarik (2021) In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting ...
Artículo Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases Braidy, Nady; Smani Hajami, Tarik; Naziroglu, Mustafa (Fontiers Media SA, 2021) The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and ...
Artículo SARAF and Orai1 contribute to endothelial cell activation and angiogenesis Galeano-Otero, Isabel; Toro Estévez, Raquel del; Khatib, Abdel Majid; Rosado, Juan Antonio; Ordóñez Fernández, Antonio; Smani Hajami, Tarik (FRONTIERS MEDIA SA, 2021) Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from ...
Artículo SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells Jardin, Isaac; Nieto Felipe, Enrique; Alvarado, Sandra; Diez Bello, Raquel; López, Jose J.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021) Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be grouped ...
Artículo Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells Jardín, Isaac; Díez-Bello, Raquel; Falcón Boyano, Débora; Alvarado, Sandra; Regodón, Sergio; Salido, Gines M.; Smani Hajami, Tarik; Rosado, Juan A. (Amer Soc Biochemistry Molecular Biology Inc, 2021) Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including ...
Artículo TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease Martín Bórnez, Marta; Galeano-Otero, Isabel; Toro Estévez, Raquel del; Smani Hajami, Tarik (doi:10.3390/ijms21176125, 2020) Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They ...
Artículo Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors. Cicvaric, Ana; Sachernegg, Hannah M.; Stojanovic, Tamara; Symmank, Dörte; Smani Hajami, Tarik; Moeslinger, Thomas; Monje, Francisco J. (2020) Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several ...
Artículo TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease Falcón Boyano, Débora; Galeano-Otero, Isabel; Martín Bórnez, Marta; Fernández Velasco, María; Gallardo Castillo, Isabel; Rosado, Juan Antonio; Smani Hajami, Tarik (doi:10.3390/cells9010173, 2020) Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac ...
Artículo Innate Immune Receptors, Key Actors in Cardiovascular Diseases Jaén, Rafael I.; Val-Blasco, Almudena; Prieto, Patricia; Gil-Fernández, Marta; Smani Hajami, Tarik; López-Sendón, José Luis (Elsevier on behalf of the American College of Cardiology Foundation, 2020) Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with ...
Artículo TRPC Channels in the SOCE Scenario Lopez, Jose J.; Jardin, Isaac; Sanchez-Collado, Jose; Salido, Gines M.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2020) Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation ...
Artículo Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells Smani Hajami, Tarik; Falcón Boyano, Débora (2019) Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel ...
Artículo TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling Falcón Boyano, Débora; Galeano-Otero, Isabel; Calderón Sánchez, Eva María; Toro Estévez, Raquel del; Martín Bórnez, Marta; Rosado, Juan Antonio; Hmadcha, Abdelkrim; Smani Hajami, Tarik (Frontiers Media, 2019) Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also ...
Artículo EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction Albarran, Letizia; Lopez, Jose J.; Jardin, Isaac; Sanchez-Collado, Jose; Berna-Erro, Alejandro; Smani Hajami, Tarik; Rosado, Juan Antonio (S. Karger AG, 2018) Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved ...
Artículo TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure Jardín, Isaac; Diez Bello, Raquel; Lopez, Jose J.; Redondo, Pedro C.; Salido, Gines M.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI AC, 2018) Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular ...
Artículo miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation López Beas, Javier; Capilla González, Vivian; Aguilera, Yolanda; Mellado, Nuria; Lachaud, Christian; Martín, Franz; Smani Hajami, Tarik; Soria Escoms, Bernat; Hmadcha, Abdelkrim (The American Society of Gene and Cell Therapy, 2018) Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this ...
Artículo Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion Domínguez Rodríguez, Alejandro; Mayoral-González, Isabel; Ávila Medina, Javier; Sánchez de Rojas de Pedro, Eva; Calderón Sánchez, Eva María; Díaz Carrasco, Ignacio; Hmadcha, Abdelkrim; Castellano Orozco, Antonio Gonzalo; Ordóñez Fernández, Antonio; Smani Hajami, Tarik (Frontiers Research Foundation, 2018) Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is ...
Tesis Doctoral Comunicación funcional entre canales de Ca2+ tipo l y canales de Ca2+ activados por reservorios y su regulación del tono vascular Ávila Medina, Javier; Ordoñez Fernández, José Antonio; Smani Hajami, Tarik (2017)
Artículo miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemiareperfusion injury Díaz, Ignacio; Calderón Sánchez, Eva María; Toro Estévez, Raquel del; Ávila Medina, Javier; Sánchez de Rojas de Pedro, Eva; Domínguez Rodríguez, Alejandro; Ordóñez Fernández, Antonio; Smani Hajami, Tarik (Nature Research, 2017) Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) ...
Tesis Doctoral Estudio molecular de la cardioprotección inducida por Urocortina frente al síndrome de isquemia/repercusión. Díaz Carrasco, Ignacio; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (2016) Las enfermedades cardiovasculares siguen siendo la principal causa de morbimortalidad en los países desarrollados (Figura ...
Artículo STIM and Orai1 Variants in Store-Operated Calcium Entry Rosado, Juan Antonio; Diez, Raquel; Smani Hajami, Tarik; Jardin, Isaac (Frontiers Research Foundation, 2016) Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx ...
Artículo Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells Ávila Medina, Javier; Calderón Sánchez, Eva María; González-Rodríguez, Patricia; Monje Quiroga, Francisco; Rosado, Juan Antonio; Castellano Orozco, Antonio Gonzalo; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (American Society for Biochemistry and Molecular Biology, 2016) Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle ...
Artículo Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery Role of EPAC2 and ERK12 Calderón Sánchez, Eva María; Díaz, Ignacio; Ordoñez, Antonio; Smani Hajami, Tarik (Public Library of Science, 2016) Urocortin-1 (Ucn-1) is an endogenous peptide that protects heart from ischemia and reperfusion (I/R) injuries. Ucn-1 is ...
Artículo Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells Pezzolla, Daniela; López Beas, Javier; Lachaud, Christian; Domínguez Rodríguez, Alejandro; Smani Hajami, Tarik; Hmadcha, Abdelkrim (Public Library of Science, 2015) Human embryonic stem cells (hESCs) retain the extraordinary capacity to differentiate into different cell types of an adult ...
Tesis Doctoral Implicación de la entrada de calcio regulada por los reservorios en la vasoconstricción y proliferación inducida por urotensina-ii en aorta Rodríguez Moyano, María; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (2012) En los últimos años, la terminación de la primera parte del Proyecto Genoma Humano ha traído consigo la identificación de ...
Tesis Doctoral Potenciación de los Mecanismos Endógenos de Protección Miocárdica frente al síndrome de Isquemia-Reperfusión Calderón Sánchez, Eva María; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (2009) Antecedentes: La cardiopatía isquémica es la principal causa de morbilidad y mortalidad en las sociedades desarrolladas, ...
Tesis Doctoral Homeostasis del calcio en miocitos del árbol arterial pulmonar Smani Hajami, Tarik; López Barneo, José; Ureña López, Juan (2000) En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ...

Perfil del autor: Smani Hajami, Tarik

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