Author profile: Santiago Pavón, Martiniano
Institutional data
Name | Santiago Pavón, Martiniano |
Department | Bioquímica y Biología Molecular |
Knowledge area | Bioquímica y Biología Molecular |
Professional category | Catedrático de Universidad |
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Statistics
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No. publications
21
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No. visits
8881
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No. downloads
52842
Publications |
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Article
![]() Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ... |
Article
![]() The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ... |
Final Degree Project
![]() El espliceosoma: La maquinaria necesaria para la vida
(2022)
Para que el material genético de una célula pueda pasar de ADN a proteínas, primero debe darse la transcripción a ARN en ... |
Final Degree Project
![]() Hemoglobinopatías estructurales: tipos, causas y tratamiento
(2021)
La hemoglobina es una proteína que se encuentra en altas concentraciones en el interior de los eritrocitos, su función ... |
Article
![]() Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ... |
Final Degree Project
![]() Complejo de reconocimiento de origen en la replicación de eucariotas
(2021)
La replicación del ADN durante el ciclo celular inicia con la licencia de replicación a través del reconocimiento por el ... |
Article
![]() Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ... |
Final Degree Project
![]() Proteínas implicadas en la plasticidad sináptica: Arc/Arg3.1
(2020)
El aprendizaje requiere la formación de nuevas redes neuronales y cambios en el citoesqueleto de las neuronas para que se ... |
Final Degree Project
![]() Implicación de los isoprenoides y la prenilación de las proteínas en la enfermedad de alzheimer y su posible uso en la terapia de esta enfermedad
(2019)
La enfermedad de Alzheimer (EA) cada día está más presente en nuestra sociedad y conforme vamos estudiando más esta ... |
Article
![]() Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ... |
Final Degree Project
![]() Vía de la P53: orígenes, inactivación en cáncer y aproximaciones terapéuticas
(2018)
La proteína p53 es un componente fundamental para la homeostasis de la célula que en condiciones normales se encuentra ... |
Article
![]() Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ... |
Final Degree Project
![]() Bases bioquímicas y avances en la terapia de la fibrosis quística
(2017)
La fibrosis quística (FQ) es un trastorno autosómico recesivo monogénico que afecta a unas 70 000 personas en todo el ... |
Final Degree Project
![]() Bases moleculares de la hemocromatosis hereditaria
(2016)
La hemocromatosis hereditaria es la enfermedad más relevante dentro de las enfermedades hereditarias debido a su alta ... |
Article
![]() Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
(Impact Journals, LLC, 2015)
Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ... |
Article
![]() Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
(2015)
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ... |
Article
![]() The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue
(Royal Society of Chemistry, 2014)
Hydroxytyrosol is a well-known phenolic compound with antioxidant properties that is found in virgin olive oil. Studies ... |
Article
![]() Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)
We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ... |
Article
![]() Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ... |
Article
![]() Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis
(American Society for Microbiology, 1995)
In vivo microdialysis was used to estimate the extracellular concentrations of ceftazidime and ceftriaxone, two expanded-spectrum ... |
PhD Thesis
![]() Estudio de la concentración de las aminas biógenas en distintas estructuras cerebrales durante el desarrollo, el envejecimiento y la deprivación visual
(1987)
Nuestro principal objetivo en este trabajo ha sido estudiar los cambio que se pueden producir en el desarrollo de las ... |