Author profile: Ruano Caballero, Diego
Institutional data
| Name | Ruano Caballero, Diego |
| Department | Bioquímica y Biología Molecular |
| Knowledge area | Bioquímica y Biología Molecular |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
36
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No. visits
11936
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No. downloads
37971
| Publications |
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Article
 Electrical pulse stimulation parameters modulate N2a neuronal differentiation
(Springer Nature, 2024)
Electrical pulse stimulation has been used to enhance the differentiation or proliferation of neuronal progenitor cells ... |
Article
Editorial: Sex differences in aging: a cognitive and behavioral perspective
(Frontiers Media, 2024)
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Article
Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration
(MDPI, 2024)
The COVID-19 pandemic has brought to the forefront the intricate relationship between SARS-CoV-2 and its impact on ... |
Article
Electrical pulse stimulation parameters modulate N2a neuronal differentiation
(Springer Nature, 2024)
Electrical pulse stimulation has been used to enhance the differentiation or proliferation of neuronal progenitor cells ... |
Final Degree Project
Efecto del ejercicio físico sobre la sintomatología menopáusica
(2023)
La menopausia es un evento fisiológico natural en la vida de las mujeres que representa la transición entre el periodo ... |
PhD Thesis
Posible papel diferencial de la autofagia en respuesta al estrés proteico en microglía y neuronas
(2022)
En esta tesis doctoral hemos afrontado el estudio de mecanismos implicados en el mantenimiento de la proteostasis en dos ... |
Final Degree Project
Privación de sueño y neurodegeneración
(2022)
Los ritmos circadianos son ciclos fisiológicos y conductuales con una periodicidad de aproximadamente 24 horas, generados ... |
Final Degree Project
Papel de la autofagia en el cáncer. ¿Ángel o demonio?
(2022)
La autofagia es un proceso celular catabólico en el que los lisosomas, en ciertas condiciones desfavorables como pueden ... |
Article
Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
(Frontiers Media S.A., 2021)
Aging is a biological and multifactorial process characterized by a progressive and irreversible deterioration of the ... |
Final Degree Project
Combustibles metabólicos y actividad física
(2021)
El músculo esquelético emplea diversos combustibles para lograr su contracción. El uso de uno u otro depende de la intensidad ... |
Final Degree Project
Efecto de la restricción calórica crónica sobre la proteostasis y la inflamación en el hígado de rata
(2021)
La restricción calórica es una de las medidas más eficaces contra el envejecimiento y las patologías asociadas al mismo ... |
Article
Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability
(Wiley-Blackwell, 2020)
Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of ... |
Final Degree Project
Microbiota en la salud y en la enfermedad
(2019)
El microbioma intestinal se compone de un diverso consorcio de microorganismos que conviven de forma simbiótica en el ... |
Article
SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
(Springer Nature, 2018)
Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative ... |
Final Degree Project
Proteostasis y degeneración macular asociada a la edad
(2017)
En los últimos 100 años, la esperanza de vida ha aumentado, por tanto, hay un envejecimiento de la población que repercute ... |
Final Degree Project
Estudio de las vías IRE1 y PERK en la activación de la autofagia inducida por LPS
(2017)
Una de las múltiples funciones del retículo endoplasmático (RE) es la de plegamiento de proteínas. Ciertos factores influyen ... |
Article
Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
(Nature Publishing Group, 2017)
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that ... |
Final Degree Project
Papel del inmunoproteosoma en enfermedades neurodegenerativas y cáncer
(2016)
Los avances científicos y la constante evolución de los métodos de experimentación han permitido conocer la gran importancia ... |
Article
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
(Taylor & Francis, 2016)
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Final Degree Project
Diversidad funcional de la ubiquitinación de proteínas
(2016)
La ubiquitinación en una modificación post-traduccional dependiente de ATP que consiste en la unión covalente de ubiquitina ... |
Article
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism
(Nature, 2015)
Targeting the ubiquitin proteasome pathway has emerged as a rational approach in the treatment of human cancers. Autophagy ... |
Article
Learning improvement after PI3K activation correlates with de novo formation of functional small spines
(Frontiers Media S.A., 2014)
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic ... |
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Article
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). ... |
Article
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
(Elsevier, 2011)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays ... |
Article
Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ... |
| PhD Thesis |
Article
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ... |
Article
Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic
(Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs ... |
| PhD Thesis |
| PhD Thesis |
| PhD Thesis |
Article
GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus
(American Society for Biochemistry and Molecular Biology, 2000)
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ... |
Article
Molecular and pharmacological characterization of native cortical γ- aminobutyric acids receptors containing both α1 and α3 subunits
(1996)
We have investigated the existence, molecular composition, and benzodiazepine binding properties of native cortical α1-α3 ... |
PhD Thesis
Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento
(1993)
La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ... |