Author profile: Rosa Acosta, Miguel Ángel de la
Institutional data
| Name | Rosa Acosta, Miguel Ángel de la |
| Department | Bioquímica Vegetal y Biología Molecular |
| Knowledge area | Bioquímica y Biología Molecular |
| Professional category | Catedrático de Universidad |
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| Publications |
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Article
 Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm.
(Oxford University Press, 2024)
Human antigen R (HuR) is an RNA binding protein mainly involved in maintaining the stability and controlling the translation ... |
PhD Thesis
 Mechanistic insights into the post-translational regulation of RNA-binding proteins in cell life and disease
(2024)
Cell signaling networks modulate gene expression in response to internal and external stimuli. Rapid cellular adaptation ... |
PhD Thesis
Novel insights into the mechanism of electron transfer in mitochondrial cytochrome c and its regulation by post-translational modifications
(2023)
Las células que componen nuestro cuerpo obtienen la mayor parte de la energía que necesitan para vivir, de los alimentos ... |
Article
Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle
(Springer Nature, 2023)
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational ... |
Article
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.
(Nature Research, 2022)
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ... |
Article
Thinking up an original scientific research project
(Turk Biyokimya Dernegi, 2022)
Writing a research proposal is not a simple task if we wish-and we do usually wish!-to succeed in putting our project into ... |
Article
Phosphorylation disrupts long-distance electron transport in cytochrome c
(Springer Nature, 2022)
t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ... |
Article
Ensuring image integrity in the digital age
(Wiley-Blackwell, 2022)
FEBS Open Bio and our fellow FEBS Press journals have a strong commitment to maintaining the integrity of the scientific ... |
Article
Entering the second decade: FEBS Open Bio in 2022
(Wiley-Blackwell, 2022)
FEBS Open Bio continues to go from strength to strength, with 2021 perhaps marking its most exciting year. In this Editorial, ... |
Article
PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ
(Research Network of Computational and Structural Biotechnology, 2022)
Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ... |
Article
Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins
(Wiley-Blackwell, 2021)
Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the ... |
Article
Membraneless organelles: a smart design for metabolic control
(Wiley Online Library, 2021)
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ... |
Article
Ten years of FEBS Open Bio
(Wiley, 2021)
This month, FEBS Open Bio celebrates its 10th birthday. To celebrate the journal's first decade, we present this special ... |
Article
Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation
(Frontiers Media S.A., 2021)
Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ... |
Article
Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants
(Wiley-Blackwell, 2021)
Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ... |
Article
Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
(Elsevier, 2021)
Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ... |
Article
Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
(Wiley-Blackwell, 2021)
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ... |
PhD Thesis
Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
(2020)
The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed ... |
Article
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ... |
Article
Exploring protein phosphorylation by combining computational approaches and biochemical methods
(Elsevier, 2020)
Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ... |
Article
Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
(Hindawi, 2020)
Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ... |
Article
Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV
(Elsevier, 2019)
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ... |
Article
Protein crosslinking improves the thermal resistance of plastocyanin immobilized on a modified gold electrode
(Elsevier, 2018)
Increasing the thermal stability of immobilized proteins is a motivating goal for improving the performance of electrochemical ... |
Article
Key Role of the Local Hydrophobicity in the East Patch of Plastocyanins on Their Thermal Stability and Redox Properties
(American Chemical Society, 2018)
Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ... |
Article
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
(National Academy of Sciences, 2018)
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ... |
Article
Long distance electron transfer through the aqueous solution between redox partner proteins
(Nature Research, 2018)
Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ... |
Article
Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
(Nature Publishing Group, 2018)
Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ... |
Article
Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics
(Wiley-Blackwell, 2018)
Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ... |
PhD Thesis
Cytosolic interaction between respiratory cytochrome c and 14-3-3 protein family members facilitates programmed cell death in humans and plants
(2017)
The development, as well as the homeostatic control of multi-cellular organisms, requires programmed cell death processes. ... |
PhD Thesis
 Phosphorylation of cytochrome C: functional and structural features
(2017)
Post-translational modifications often modulate protein function. Actually, phosphorylation of cytochrome c occurs in vivo ... |
Article
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
(Oxford University Press, 2017)
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the ... |
Article
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
(National Academy of Sciences, 2017)
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its ... |
Article
RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate
(Frontiers Media, 2017)
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby ... |
PhD Thesis
Estructura y estabilidad en plastocianinas de cianobacterias
(2016)
ESTRUCTURA Y ESTABILIDAD EN PLASTOCIANINAS DE CIANOBACTERIAS La elucidación de los factores que determinan las diferencias ... |
Article
The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor
(Public Library of Science, 2016)
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ... |
PhD Thesis
Redox biointeractome of cytochromes in respiration and photosynthesis
(2015)
Protein complex formation is at least a two-step process in which the formation of a final, well-defined complex entails ... |
Article
Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength
(Elsevier, 2015)
The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous ... |
Article
Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c
(National Academy of Sciences, 2015)
Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA ... |
Article
A common signalosome for programmed cell death in humans and plants
(Nature Publishing Group, 2014)
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Article
The dynamic complex of cytochrome c6 and cytochrome f studied with paramagnetic NMR spectroscopy
(Elsevier B.V., 2014)
The rapid transfer of electrons in the photosynthetic redox chain is achieved by the formation of short-lived complexes ... |
Article
Cytochrome c1 exhibits two binding sites for cytochrome c in plants
(Elsevier, 2014)
n plants, channeling of cytochrome c molecules between complexes III and IV has been purported to shuttle electrons within ... |
Article
Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis
(American Society for Biochemistry and Molecular Biology, 2014)
Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in ... |
Article
Temperature-driven changeover in the electron-transfer mechanism of a thermophilic plastocyanin
(American Chemical Society, 2014)
Electron-transfer kinetics of the thermophilic protein Plastocyanin fromPhormidium laminosumadsorbed on 1,ω-alkanedithiol ... |
PhD Thesis
Structural approach to the hur function
(2013)
En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el ... |
Article
Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c
(Wiley: FEBS Journal, 2013)
l‐galactono‐1,4‐lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. ... |
Article
New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants
(American Society for Biochemistry and Molecular Biology, 2013)
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ... |
Article
Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin
(American Society for Biochemistry and Molecular Biology, 2013)
Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood ... |
Article
Preface to the mini-theme issue of IUBMB life on biointeractomics
(Taylor & Francis, 2013)
|
PhD Thesis
Desvelando el curso evolutivo de la red de proteínas que interaccionan con el Citocromo C en la muerte celular programada
(2012)
La organización celular de los organismos fue descubierta a mediados del siglo XIX por Schwann y Schleiden (1847). Poco ... |
Article
The cytochrome f–plastocyanin complex as a model to study transient interactions between redox proteins
(Wiley, 2012)
Transient complexes, with a lifetime ranging between microseconds and seconds, are essential forbiochemical reactions ... |
Article
Voltammetric study of the adsorbed thermophilic plastocyanin from Phormidium laminosum up to 90 °c
(Elsevier, 2012)
Redox thermodynamics and kinetics of plastocyanin from Phormidium laminosum, and of azurin from Pseudonomas aeruginosa, ... |
Article
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
(Elsevier, 2012)
Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ... |
PhD Thesis
Análisis Estructural de los Determinantes de la Estabilidad en Plastocianinas
(2011)
La vida se encuentra en casi cualquier lugar de la Tierra, tanto en las grietas hidrotermales de los suelos marinos o en ... |
Article
Cytochrome c signalosome in mitochondria
(Springer, 2011)
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ... |
Article
How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011)
Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ... |
Article
Modulation of copper site properties by remote residues determines the stability of plastocyanins
(Elsevier, 2010)
The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ... |
Article
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
(Elsevier, 2010)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ... |
Patent. Invention
Construcción génica que codifica para el citocromo c y procedimiento de obtención
(Oficina Española de Patentes y Marcas (OEPM), 2009)
Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica que ... |
Article
Electrostatic strain and concerted motions in the transient complex between plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosum
(Elsevier, 2009)
Many fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. ... |
| PhD Thesis |
| PhD Thesis |
PhD Thesis
Transferencia de electrones y complejos transitorios entre proteínas: análisis funcional de la interacción entre el citocromo f y la platocianina
(2007)
Con el presente trabajo de Tesis se pretende establecer las diferencias funcionales entre sistemas de transferencia de ... |
Article
The atypical iron-coordination geometry of cytochrome f remains unchanged upon binding to plastocyanin, as inferred by XAS
(Springer Verlag, 2006)
The transient complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc sp. PCC 7119 has been analysed ... |
| PhD Thesis |
Article
Structure of the Complex between Plastocyanin and Cytochrome f from the Cyanobacterium Nostoc sp. PCC 7119 as Determined by Paramagnetic NMR
(Elsevier, 2005)
The complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc has been characterized by NMR spectroscopy. ... |
Article
NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6
(Elsevier, 2005)
A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ... |
PhD Thesis
Reconocimiento molecular y análisis estructural de complejos transitorios entre proteínas
(2005)
Las interacciones trasitorias entre biomoléculas se han convertido en el centro de la investigación de muchas áreas de la ... |
Article
The Efficient Functioning of Photosynthesis and Respiration in Synechocystis sp. PCC 6803 Strictly Requires the Presence of either Cytochrome c6 or Plastocyanin
(Elsevier, 2004)
In cyanobacteria, cytochrome c6 and plastocyanin are able to replace each other as redox carriers in the photosynthetic ... |
Article
The Interactions of Cyanobacterial Cytochromec6 and Cytochrome f, Characterized by NMR
(Elsevier, 2002)
During oxygenic photosynthesis, cytochromec6 shuttles electrons between the membrane-bound complexes cytochrome bf and ... |
Article
Anabaena sp. PCC 7119 Flavodoxin as Electron Carrier from Photosystem I to Ferredoxin-NADP+Reductase: ROLE OF TRP57 AND TYR94
(Elsevier, 2002)
The influence of the amino acid residues sandwiching the flavin ring in flavodoxin (Fld) from the cyanobacteriumAnabaena ... |
Article
An evolutionary analysis of the reaction mechanisms of photosystem I reduction by cytochrome c6 and plastocyanin
(Elsevier, 2002)
Photosystem I reduction by the soluble metalloproteins cytochrome c6 and plastocyanin, which are alternatively synthesized ... |
PhD Thesis
Identificación de regiones isofuncionales en el citocromo c6 y en la plastocianina
(2001)
Una de las líneas de investigación mas intereses de la bioquímica contemporánea es el estudio de la relación entre la ... |
Article
A Single Arginyl Residue in Plastocyanin and in Cytochrome c6 from the Cyanobacterium Anabaenasp. PCC 7119 Is Required for Efficient Reduction of Photosystem I
(Elsevier, 2001)
Positively charged plastocyanin from Anabaena sp. PCC 7119 was investigated by site-directed mutagenesis. The reactivity ... |
Article
Site-directed Mutagenesis of Cytochromec 6 from Synechocystissp. PCC 6803
(Elsevier, 1999)
This paper reports the first site-directed mutagenesis analysis of any cytochrome c 6, a heme protein that performs the ... |
Article
Sobre la teoría y práctica de la ciencia
(CSIC, 1999)
La investigación y el desarrollo —normalmente conocidos por su abreviatura I+D—, así como la innovación tecnológica se ... |
Article
Oxidizing Side of the Cyanobacterial Photosystem I
(Elsevier, 1999)
Photosystem I (PSI) interacts with plastocyanin or cytochrome c 6 on the luminal side. To identify sites of interaction ... |
Article
Site-directed Mutagenesis of Cytochromec 6 from Anabaena Species PCC 7119
(Elsevier, 1999)
A number of surface residues of cytochromec 6 from the cyanobacterium Anabaenasp. PCC 7119 have been modified by site-directed ... |
PhD Thesis
Citocromo c6 y plastocianina de la cianobacteria Synechocystis PCC 6803: estudio de la relación estructura-función en las proteínas nativas y modificadas por mutagénesis dirigida
(1998)
El estudio de los mecanismos de reconocimiento molecular y transferencia de electrones entre proteína se ha abordado en ... |
PhD Thesis
Transferencia de electrones en el lado oxidante del fotosistema I. Equivalencia funcional entre el citocromo c6 y la plastocianina
(1995)
El presente trabajo forma parte del realizado por el grupo al que el doctorando se encuentra adscrito, en el que se busca ... |
Article
Fotosíntesis: sol, agua, tierra y aire
(RBA Revistas, 1993)
|
PhD Thesis
Conversión química y biológica de la energía luminosa fotoproducción de peroxido de hidrógeno
(1988)
Todas las formas de vida hasta ahora conocidas en nuestro planeta requieren energía para su crecimiento y conservación. ... |
PhD Thesis
Producción fotoquímica y fotobiológica de peróxido de hidrógeno
(1986)
Se ha estudiado la optimización del proceso de reducción del oxigeno molecular a peróxido de hidrogeno impulsado por energía ... |
| Article |
Article
Carbon dioxide-mediated decomposition of hydrogen peroxide in alkaline solutions
(Faraday Division of the Chemical Society, 1984)
Rapid hydrogen peroxide decomposition in aerated alkaline solutions is described, the maximum rate being attained at pH ... |
| PhD Thesis |