Perfil del autor: Rodríguez Martínez, José Manuel
Datos institucionales
| Nombre | Rodríguez Martínez, José Manuel |
| Departamento | Microbiología |
| Área de conocimiento | Microbiología |
| Categoría profesional | Catedrático de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
25
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Nº visitas
3598
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Nº descargas
7463
| Publicaciones |
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Artículo
 Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
(Oxford University Press, 2024)
Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ... |
Tesis Doctoral
Optimisation of the therapeutic potential of fosfomycin against Enterobacteriaceae: characterisation of genetic and physiological factors related to resistance and antimicrobial activity
(2023)
Since the discovery of the first antimicrobials, bacteria with resistance mechanisms against them have been detected. The ... |
Tesis Doctoral
Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
(2023)
One of the major threats to human health is the emergence of antimicrobial resistance. Since the discovery of antimicrobials, ... |
Artículo
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ... |
Artículo
Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents
(American Society for Microbiology, 2022)
Escherichia coli ST131 clade C is an important driver for fluoroquinolone resistance (FQ-R). We conducted a prospective ... |
Artículo
Interplay between IncF plasmids and topoisomerase mutations conferring quinolone resistance in the Escherichia coli ST131 clone: stability and resistance evolution
(Springer, 2021)
The Escherichia coli ST131 H30-Rx subclone vehicles CTX-M-15 plasmids and mutations in gyrA and parC conferring multidrug ... |
Artículo
Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress
(American Society for Microbiology, 2021)
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ... |
Artículo
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
(American Society for Microbiology, 2021)
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ... |
Artículo
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
(Frontiers Media, 2021)
Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ... |
Artículo
Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
(Elsevier, 2021)
Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ... |
Artículo
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ... |
| Tesis Doctoral |
Artículo
Cellular Response to Ciprofloxacin in Low-Level Quinolone-Resistant Escherichia coli
(Frontiers Media, 2017)
Bactericidal activity of quinolones has been related to a combination of DNA fragmentation, reactive oxygen species (ROS) ... |
Artículo
Quinolone Resistance Reversion by Targeting the SOS Response
(American Society for Microbiology, 2017)
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We ... |
Artículo
Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli
(American Society for Microbiology, 2016)
Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently ... |
Artículo
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
(American Society for Microbiology, 2015)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ... |
Tesis Doctoral
Interacción de mecanismos plasmídicos y cromosómicos de resistencia a Quinolonas en Escherichia coli y su efecto en la resistencia, fitness y toxicidad celular
(2014)
Las fluoroquinolonas, junto a los beta-lactámicos, son los antimicrobianos de mayor uso clínico. Por tanto la aparición ... |
Artículo
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
(American Society for Microbiology, 2011)
This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ... |
Artículo
Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6′)-Ib-cr
(American Society for Microbiology, 2011)
The accuracy of the MicroScan WalkAway, BD Phoenix, and Vitek-2 systems for susceptibility testing of quinolones and ... |
Artículo
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
(American Society for Microbiology, 2009)
We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ... |
Artículo
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants
(BioMed Central, 2008)
Background Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for ... |
Artículo
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008)
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ... |
Artículo
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant ... |
Tesis Doctoral
 Resistencia a quinolonas mediada por plásmido en enterobacteriaceae
(2006)
En 1998, se describió por primera vez resistencia a quinolonas transmisible horizontalmente mediante un plásmido conjugativo. ... |
Artículo
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
(American Society for Microbiology, 2005)
Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ... |