Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Author profile: Pérez Simón, José Antonio
Institutional data
| Name | Pérez Simón, José Antonio |
| Department | Medicina |
| Knowledge area | Medicina |
| Professional category | Profesor Titular de Universidad (Pza. V) |
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Statistics
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No. publications
77
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No. visits
6173
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No. downloads
9966
| Publications |
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Article
 Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring
(Frontiers Media S.A., 2024)
Introduction: Loss of B-cell aplasia (BCA) is a well-known marker of functional loss of CD19 CAR-T. Most relapses and loss ... |
Article
Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)
BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ... |
Article
Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry
(Ferrata Storti Foundation, 2024)
Treatment options for patients with secondary acute myeloid leukemia (sAML) and AML with myeloid-related changes (AMLMRC) ... |
Article
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
(Frontiers Media S.A., 2023)
Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD ... |
PhD Thesis
Uso de cannabinoides para el tratamiento de hemopatías malignas
(2023)
Aunque el sistema hematopoyético e inmunológico muestran altos niveles del receptor cannabinoide CB2, el efecto de los ... |
PhD Thesis
Inhibición de la vía de señalización Hedgehog con glasdegib en pacientes con enfermedad injerto contra receptor crónica esclerodermiforme: resultados de un ensayo piloto de fase I/II
(2023)
La enfermedad injerto contra receptor crónica esclerodermiforme (EICRcs) se caracteriza por la fibrosis cutánea progresiva ... |
Article
Prognostic value of measurable residual disease in patients with AML undergoing HSCT: a multicenter study
(MDPI, 2023)
Allogeneic hematopoietic stem cell transplantation (HSCT) represents the best therapeutic option for many patients with ... |
PhD Thesis
Leucemia mieloide aguda con cambios relacionados con mielodisplasia: caracterización citomorfológica, citogenética y molecular, y valor pronóstico de mutaciones en el gen ASXL1
(2023)
La clasificación de las leucemias mieloides agudas (LMA) tiene como objeto la definición de entidades con un perfil clínico, ... |
Article
Editorial: Regulatory T cells in graft versus host disease
(Frontiers Media, 2023)
Regulatory T cells (Tregs) are modulators of the immune system that play a key role in maintaining self-tolerance. Treg ... |
Article
Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia
(Elsevier, 2023)
Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect ... |
Article
Targeting Hedgehog Signaling with Glasdegib in Patients with Refractory Sclerotic Chronic GVHD: A Report of Two Phase I/II Trials
(American Association for Cancer Research, 2023)
Purpose: Sclerotic chronic GVHD (scGVHD) is characterized by progressive skin fibrosis and frequent refractoriness to ... |
Article
Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real life data from the PETHEMA registry
(MDPI, 2023)
Next–Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents ... |
Article
All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells
(Ferrata Storti Foundation, 2023)
B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple ... |
Article
LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors
(Frontiers Media S.A., 2023)
Introduction: The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with ... |
Article
Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies
(Frontiers Media, 2023)
Purpose: CAR-T cell therapy has proven to be a disruptive treatment in the hematology field, however, less than 50% of ... |
Article
A phase II, prospective, randomized, open-label study of defibrotide added to standard-of-care prophylaxis for the prevention of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
(Ferrata Storti Foundation, 2023)
Acute graft-versus-host disease (aGvHD) is a life-threatening complication typically occurring within 100 days after ... |
Article
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
(Springer Nature, 2023)
Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to ... |
Article
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression
(Frontiers Media S.A., 2023)
Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a ... |
Article
First-in-human study of JNJ-63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia
(Wiley, 2022)
This study aimed to identify a recommended phase II dose and evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, ... |
Article
Impact of FLT3–ITD mutation status and its ratio in a cohort of 2901 patients undergoing upfront intensive chemotherapy: a PETHEMA registry study
(MDPI, 2022)
FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid ... |
| PhD Thesis |
Article
Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib
(Nature Publishing Group, 2022)
Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as ... |
Article
 Phase II Trial of Allogeneic Transplantation Plus Novel Drugs in Multiple Myeloma: Effect of Intensifying Reduced-Intensity Conditioning with Bortezomib and Adding Maintenance Treatment
(Elsevier Inc., 2022)
The use of reduced-intensity conditioning (RIC) regimens has decreased the risk of nonrelapse mortality (NRM) after ... |
Article
Comparison of outcomes for HLA-matched sibling and haplo identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT
(Springer Nature, 2022)
Myelodysplastic syndromes (MDS) are the second common indication for an Allo-HCT. We compared the outcomes of 1414 matched ... |
Article
CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets
(Elsevier, 2022)
Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) ... |
Article
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection
(Elsevier, 2022)
CD160 is a member of the immunoglobulin superfamily with a pattern of expression mainly restricted to cytotoxic cells. To ... |
Article
Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/ PD-1 Interaction and NK Cell Mediated Hybrid Resistance
(FRONTIERS MEDIA SA, 2022)
The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed ... |
Article
Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience
(WILEY, 2022)
Graft versus host disease (GVHD) is a severe complication after allogenic hematopoietic cell transplantation (HSCT). Several ... |
Article
Effect of Vitamin D on Graft-versus-Host Disease
(MDPI, 2022)
The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts ... |
Article
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
(Nature Publishing Group, 2022)
The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells ... |
Article
Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients
(Taylor & Francis LTD, 2022)
In the midst of the COVID-19 pandemic, different vaccines in front of SARS-CoV-2 have been approved and administered in ... |
| Article |
Article
Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project
(Ferrata Storti Foundation, 2021)
Next-generation sequencing (NGS) has recently been introduced to efficiently and simultaneously detect genetic variations ... |
Article
Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021)
Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In ... |
Article
Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease
(Nature Publishing Group, 2021)
In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation ... |
Article
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021)
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ... |
Article
Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial
(Springer, 2021)
This analysis from the phase II BRIGHT AML 1003 trial reports the long-term efficacy and safety of glasdegib + low-dose cytarabine ... |
Article
MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages
(Wiley, 2021)
Scope: The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to ... |
Article
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab
(Nature Publishing Group, 2021)
Multiple myeloma (MM) is incurable, so there is a significant unmet need for effective therapy for patients with relapsed ... |
Article
Long-Term Outcomes After Autologous Versus Allogeneic Stem Cell Transplantation in Molecularly-Stratified Patients With Intermediate Cytogenetic Risk Acute Myeloid Leukemia: A PETHEMA Study.
(Elsevier, 2021)
Acute myeloid leukemia (AML) with intermediate risk cytogenetics (IRcyto) comprises a variety of biological enti- ties ... |
Article
Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases
(MDPI, 2021)
Antimicrobial stewardship programs (ASPs) in hematological patients are especially relevant. However, information about ... |
Article
T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients
(FERRATA STORTI FOUNDATION, 2021)
Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem ... |
Article
Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model
(Elsevier, 2020)
Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory ... |
Article
The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens
(MDPI, 2020)
Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and ... |
Article
ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype
(Wiley Open Access, 2020)
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are poor outcome leukemias. Its diagnosis is based ... |
Article
Efficacy of bortezomib to intensify the conditioning regimen and the graft-versus-host disease prophylaxis for high-risk myeloma patients undergoing transplantation
(Springer Nature, 2020)
This multicenter phase I trial was designed to evaluate the safety and efficacy of bortezomib (Bz) as part of both the ... |
Article
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
(American Society of Clinical Oncology, 2020)
PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in ... |
Article
Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma
(Frontiers Media, 2020)
Multiple myeloma (MM) remains an incurable disease regardless of recent advances in the field. Therefore, a substantial ... |
Article
Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study
(Springer Nature, 2020)
Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. ... |
Article
Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications
(MDPI, 2018)
Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium ... |
Article
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation
(Springer Nature, 2018)
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate ... |
Article
Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting
(Springer, 2018)
Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic ... |
Article
Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”
(Frontiers Media, S.A., 2018)
The relevance of the immune system in cancer has long been studied. Autologous adoptive T cell therapies, based on the use ... |
Article
IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q-AML
(Taylor & Francis, 2018)
Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard ... |
Article
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation
(Taylor & Francis, 2018)
Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and ... |
PhD Thesis
Nuevas modalidades de inmunoprofilaxis en trasplante: Inhibidores del proteosoma
(2017)
El trasplante alogénico de progenitores hematopoyéticos es una opción potencialmente curativa para numerosos pacientes con ... |
PhD Thesis
 Strategies to obtain tumor-reactive cells for cancer immunotherapy by cell sorting and genetic modifications of T lymphocytes.
(2017)
Los recientes avances en el campo de la inmunoterapia contra el cáncer han hecho posible que dicha técnica se convierta ... |
| PhD Thesis |
Article
Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis
(BioMed Central, 2017)
Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efcacy in myelofbrosis. In recent years, research in ... |
Article
Immunomodulatory Effect of Vitamin D after Allogeneic Stem Cell Transplantation: Results of a Prospective Multicenter Clinical Trial
(American Association for Cancer Research, 2016)
Purpose: We describe the results of a prospective multicenter phase I/II trial evaluating the impact of the use of vitamin ... |
| PhD Thesis |
PhD Thesis
Efecto inmunomodulador de la vitamina D en el periodo postrasplante alogénico de progenitores hematopoyéticos
(2016)
El presente trabajo de tesis se basa en un ensayo clínico multicéntrico realizado a nivel nacional sobre una población de ... |
Article
Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
(2016)
It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to ... |
Article
The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor
(Public Library of Science, 2016)
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ... |
Article
Multivariable time-dependent analysis of the impact of azacitidine in patients with lower-risk myelodysplastic syndrome and unfavorable specific lower-risk score
(Elsevier, 2015)
Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. ... |
Article
Human Bone Marrow Stromal Cells Differentiate Into Corneal Tissue and Prevent Ocular Graft-Versus-Host Disease in Mice
(SAGE Journals, 2015)
Clinical trials have assessed the use of human bone marrow stromal cells (hBMSCs) for the treatment of immune-related ... |
Article
Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study
(Ferrata Storti Foundation, 2015)
This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat ... |
Article
PTPN13 and beta-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche
(Elsevier, 2015)
The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the ... |
PhD Thesis
Cambios en los perfiles de expresión génica en condiciones fisiológicas versus patológicas en el sistema hematopoyético
(2014)
El trabajo realizado en esta tesis doctoral consiste en el estudio de los cambios en la expresión génica que sufren las ... |
Article
An Active Isodicentric X Chromosome in a Case of Refractory Anaemia with Ring Sideroblasts Associated with Marked Thrombocytosis
(Hindawi, 2014)
Refractory anaemia with ring sideroblasts and marked thrombocytosis (RARS-T) is a provisional entity in the World Health ... |
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Article
Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis
(Elsevier, 2013)
Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase ... |
Article
The combination of sirolimus plus tacrolimus improves outcome after reduced-intensity conditioning, unrelated donor hematopoietic stem cell transplantation compared with cyclosporine plus mycofenolate
(Ferrata Storti Foundation, 2013)
Different types of graft-versus-host disease prophylaxis have been proposed in the setting of reduced intensity and ... |
Article
The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation
(Ferrata Storti Foundation, 2012)
Background We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion ... |
Article
Evaluation of prognostic factors among patients with chronic graft-versus-host disease
(Ferrata-Storti Foundation, 2011)
Background: Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation ... |
Article
Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial
(2011)
This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for ... |