Author profile: Pascual Hernández, Álvaro
Institutional data
Name | Pascual Hernández, Álvaro |
Department | Microbiología |
Knowledge area | Microbiología |
Professional category | Catedrático de Universidad (V) |
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Publications |
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PhD Thesis
Farmacocinética y farmacodinamia de piperacilina/tazobactam y fosfomicina en pacientes con bacteriemia por enterobacteriaceae
(2024)
En esta tesis se aborda el estudio de la farmacocinética y farmacodinamia de dos antimicrobianos en bacteriemias por ... |
Article
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress
(Elsevier, 2024)
In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, ... |
Article
Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
(Oxford University Press, 2024)
Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ... |
Article
Activity of imipenem/relebactam and comparators against KPC-producing Klebsiella pneumoniae and imipenem-resistant Pseudomonas aeruginosa
(Springer, 2023)
Purpose: Relebactam is a novel β-lactamase inhibitor, which, when combined with imipenem/cilastatin, is active against ... |
PhD Thesis
Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
(2023)
One of the major threats to human health is the emergence of antimicrobial resistance. Since the discovery of antimicrobials, ... |
Article
Synergistic effect of SOS response and GATC methylome suppression on antibiotic stress survival in Escherichia coli
(https://journals.asm.org/doi/epdf/10.1128/aac.01392-22, 2023)
The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent ... |
Article
RecA inactivation as a strategy to reverse the heteroresistance phenomenon in clinical isolates of Escherichia coli
(Elsevier, 2023)
RecA inhibition could be an important strategy to combat antimicrobial resistance because of its key role in the SOS ... |
Article
Interhospital Spread of blaVIM-1- and blaCTX-M-15-Producing K. pneumoniae ST15 on an IncR Plasmid in Southern Spain
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
In 2014–2015, the main CTX-M-15- and OXA-48-producing clone in our region was ST15. Recently, K. pneumoniae ST15 isolates ... |
Article
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial
(Oxford Academic, 2023)
Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections ... |
Article |
Article
In Vitro Activity of Cefiderocol Compared to Other Antimicrobials against a Collection of Metallo-Beta-Lactamase-Producing Gram-Negative Bacilli from Southern Spain
(American Society for Microbiology, 2023)
In this study, we aimed to comparatively evaluate the in vitro activity of cefiderocol versus other antimicrobials against ... |
PhD Thesis
Actividad de biocidas frente a aislados de Klebsiella pneumoniae productor de carbapenemasa
(2022)
La diseminación de clones epidémicos de Klebsiella pneumoniae productor de carbapenemasa (Kp-PC) es un problema de salud ... |
Article
Characterization of Extended-Spectrum β-Lactamase-Producing Shigella sonnei in Spain: Expanding the Geographic Distribution of Sequence Type 152/CTX-M-27 Clone
(American Society for Microbiology, 2022)
We describe the first occurrence in Spain of community cases of CTX-M-27-producing Shigella sonnei sequence type 152 ... |
Article
Identification of a Stable Chromosomal Tandem Multicopy of bla(VIM-63), a New bla(VIM-2) Carbapenemase
(American Society for Microbiology, 2022)
This study characterizes a new genetic structure containing a multicopy of a bla(VIM-2) variant with an A676C substitution, ... |
PhD Thesis
Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico
(2022)
En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ... |
Article
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ... |
Article
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial
(Jama Nerwork Open, 2022)
Importance The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant ... |
Article
Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents
(American Society for Microbiology, 2022)
Escherichia coli ST131 clade C is an important driver for fluoroquinolone resistance (FQ-R). We conducted a prospective ... |
Article
Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19
(Nature Publishing Group, 2022)
The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we ... |
Article
Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software
(Frontiers Media S.A., 2022)
In this study, we evaluate the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry ... |
Article
Off-target effects of bacillus Calmette–Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19
(WILEY, 2022)
Background and objectives. Because of its beneficial off-target effects against non-mycobacterial infectious diseases, ... |
Article
The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection
(Nature Publishing Group, 2022)
Since their discovery, toxin-antitoxin (TA) systems have captivated the attention of many scientists. Recent studies have ... |
Article
CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3
(Frontiers Media S.A., 2022)
Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the ... |
Article
Phenotypic and Genomic Comparison of Klebsiella pneumoniae Lytic Phages: vB_KpnM-VAC66 and vB_KpnM-VAC13
(MDPI, 2021)
Klebsiella pneumoniae is a human pathogen that worsens the prognosis of many immuno compromised patients. Here, we annotated ... |
Article
Interplay between IncF plasmids and topoisomerase mutations conferring quinolone resistance in the Escherichia coli ST131 clone: stability and resistance evolution
(Springer, 2021)
The Escherichia coli ST131 H30-Rx subclone vehicles CTX-M-15 plasmids and mutations in gyrA and parC conferring multidrug ... |
Article
In vitro activity of cefiderocol and comparators against isolates of Gram-negative bacterial pathogens from a range of infection sources: SIDERO‑WT‑2014−2018 studies in Spain
(Science Direct, 2021)
Objectives: The incidence of antimicrobial resistance in Europe is rising. Cefiderocol is approved in Eu- rope for treatment ... |
Article
Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress
(American Society for Microbiology, 2021)
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ... |
Article
CON: carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant enterobacterales
(2021)
Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone resistant ... |
Article
Reporting antimicrobial susceptibilities and resistance phenotypes in Staphylococcus spp.: a nationwide proficiency study
(Oxford University Press, 2021)
Objectives To evaluate the proficiency of microbiology laboratories in Spain in antimicrobial susceptibility testing (AST) ... |
Article
Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnMVAC13 against clinical isolates of klebsiella pneumoniae
(American Society Microbiology, 2021)
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different strategies (resistance and ... |
Article
Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients
(Willey-Blackwell, 2021)
Background Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for ... |
Article
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
(American Society for Microbiology, 2021)
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ... |
Article
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
(Frontiers Media, 2021)
Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment ... |
Article
Propensity score and desirability of outcome ranking analysis of ertapenem for treatment of nonsevere bacteremic urinary tract infections due to extended-spectrum-beta-lactamase-producing enterobacterales in kidney transplant recipients
(American Society Microbiology, 2021)
There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase ... |
Article
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
(Frontiers Media, 2021)
Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ... |
Article
Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gramnegative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases
(Oxford University Press, 2021)
Background: Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide ... |
Article
Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
(Elsevier, 2021)
Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ... |
Article
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial
(BMJ Publishing Group, 2021)
Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant ... |
Article
Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients
(Elsevier, 2021)
Objectives: This study aimed to determine rates and risk factors of extended-spectrum b-lactamaseproducing Enterobacteriaceae ... |
PhD Thesis
Caracterización epidemiológica y clínica de la infección y colonización por Escherichia coli perteneciente al complejo clonal O25b/ST131
(2020)
Introducción. Escherichia coli secuenciotipo 131 (ST131) es un clon que combina capacidad de propagación exitosa, resistencia ... |
Article
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
(MDPI, 2020)
Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a ... |
Article
In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
(Nature Research, 2020)
The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value of antimicrobials, which had ... |
Article
Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: the impact of cytomegalovirus disease and lymphopenia
(BMC, 2020)
Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is ... |
Article
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ... |
Article
Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae
(2020)
Klebsiella pneumoniae is the clinically most important species within the genus Klebsiella and, as a result of the continuous ... |
Article
Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
(Oxford University Press, 2020)
Objectives: To explore the effect of combining defects in DNA repair systems with the presence of fosfomycin-resistant ... |
Article
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
(Oxford, 2020)
BACKGROUND: Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli ... |
Article
Role of low-level quinolone resistance in generating tolerance in Escherichia coli under therapeutic concentrations of ciprofloxacin
(Oxford University Press, 2020)
Background: Tolerance (including persistence) and resistance result in increased survival under antibiotic pressure. Objectives: ... |
PhD Thesis |
Article
OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014-2015
(Oxford University Press, 2019)
The aim of this study was to characterize the population structure of 56 OXA-48-like-producing Klebsiella pneumoniae ... |
Article
Impact of De-escalation on Prognosis of Patients With Bacteremia due to Enterobacteriaceae: A Post Hoc Analysis From a Multicenter Prospective Cohort
(Oxford University Press, 2019)
Background More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy ... |
Article
Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence
(Biomed Central, 2018)
Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the ... |
Article
Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia
(Elsevier, 2018)
Objective: To evaluate the ability of the BioFire FilmArray Blood Culture Identification (BCID) panel to rapidly detect ... |
PhD Thesis
Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.
(2018)
El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ... |
Article
Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain
(Springer, 2018)
Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated ... |
Article
Duration of Colonization by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: a Prospective Cohort Study
(Oxford University Press, 2018)
Duration of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated ... |
Article
Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients
(Elsevier, 2018)
Objectives: The Escherichia coli O25b-associated ST131 clonal group was recently found to be prevalent in our area as a ... |
Article
Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.
(Frontiers Media, 2018)
Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of ... |
Article
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
(Elsevier, 2018)
Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ... |
PhD Thesis |
PhD Thesis
Impacto de la concentración mínima inhibitoria (cmi) y de los puntos de corte clínicos (clsi y eucast) de las combinaciones betalactámicos / inhibidores de betalactamasas en el pronóstico de bacteriemias por enterobacteriaceae
(2017)
Los puntos de corte clínicos se utilizan para predecir la eficacia terapéutica de un antibiótico cuando se utiliza a la ... |
PhD Thesis
Prevalencia de Escherichia Coli o25b: h4-st131 productor o no de betalactamasa de espectro extendido (BLEE) en Sevilla
(2017)
Hasta finales de los años 90 K. pneumoniae era la principal enterobacteria implicada en la producción de estas enzimas, ... |
PhD Thesis |
Article
EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study
(2017)
Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. ... |
Article
Cellular Response to Ciprofloxacin in Low-Level Quinolone-Resistant Escherichia coli
(Frontiers Media, 2017)
Bactericidal activity of quinolones has been related to a combination of DNA fragmentation, reactive oxygen species (ROS) ... |
Article
Bacteraemia due to non-ESBL-producing Escherichia coli O25b:H4 sequence type 131: insights into risk factors, clinical features and outcomes
(Elsevier, 2017)
The epidemiology and outcomes of bloodstream infections (BSIs) caused by Escherichia coli ST131 isolates not producing ... |
Article
Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli
(American Society for Microbiology, 2016)
Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently ... |
Article
A multinational, preregistered cohort study of β-lactam/β-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-β-lactamase-producing enterobacteriaceae
(American Society for Microbiology, 2016)
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem ... |
Article
Modelling the epidemiology of Escherichia coli ST131 and the impact of interventions on the community and healthcare centres
(Cambridge University Press, 2016)
ST131 Escherichia coli is an emergent clonal group that has achieved successful worldwide spread through a combination of ... |
Article
Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010)
(2016)
Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by ... |
Article
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
(American Society for Microbiology, 2015)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ... |
Article
Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem
(American Society for Microbiology, 2015)
The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by ... |
PhD Thesis
Tratamiento de bacteriemias por enterobacterias productoras de β-lactamasas de espectro extendido la combinación de β-lactámicosinhibidores de β-lactamasas como alternativa a los carbapenemes. Proyecto INCREMENT
(2015)
En los últimos años, la diseminación de las enterobacterias productoras de β-lactamasas de espectro extendido (E-BLEE) se ... |
PhD Thesis
Estudio clínico y epidemiológico de un brote nosocomial producido por klebsiella oxytoca productora de IMP-8
(2015)
Klebsiella oxytoca, al igual que K. pneumoniae, son dos patógenos humanos asociados a múltiples cuadros clínicos, pero ... |
Article
Fosfomycin versus meropenem in bacteraemic urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli (FOREST): study protocol for an investigator-driven randomised controlled trial
(BMJ Publishing Group, 2015)
Introduction Finding therapeutic alternatives to carbapenems in infections caused by extended-spectrum β-lactamase-producing ... |
Article
Is reduced vancomycin susceptibility a factor associated with poor prognosis in MSSA bacteraemia?
(Oxford University Press, 2015)
Objectives: The known data about the influence of vancomycin MIC on Staphylococcus aureus bacteraemia are contradictory. ... |
PhD Thesis
Interacción de mecanismos plasmídicos y cromosómicos de resistencia a Quinolonas en Escherichia coli y su efecto en la resistencia, fitness y toxicidad celular
(2014)
Las fluoroquinolonas, junto a los beta-lactámicos, son los antimicrobianos de mayor uso clínico. Por tanto la aparición ... |
PhD Thesis
Estudio multicéntrico de bacteriemias por escherichia coli productor de betalactamasas de espectro extendido: factores de riesgo, características microbiológicas de impacto clínico
(2014)
Esta tesis es el resultado de un estudio de investigación multicéntrico en el que participaron 13 hospitales y un centro ... |
Article
Global dissemination of a multidrug resistant Escherichia coli clone
(National Academy of Sciences, 2014)
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a ... |
Article
Epidemiologic and Clinical Impact of Acinetobacter baumannii Colonization and Infection: A Reappraisal
(Lippincott Williams & Wilkins, 2014)
Acinetobacter baumannii is one of the most important antibiotic-resistant nosocomial bacteria. We investigated changes in ... |
Article
Contribution of Efflux Pumps, Porins, and B-Lactamases to Multidrug Resistance in Clinical Isolates of Acinetobacter baumannii
(American Society for Microbiology, 2013)
Weinvestigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones ... |
Article
Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics
(American Society for Microbiology, 2013)
A total of 1,021 extended-spectrum- -lactamase-producing Escherichia coli (ESBLEC) isolates obtained in 2006 during a ... |
Article
Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-B-Lactamase- Producing Escherichia coli
(American Society for Microbiology, 2013)
We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to ... |
Article
Epidemiological and Clinical Complexity of Amoxicillin-Clavulanate- Resistant Escherichia coli
(American Society for Microbiology, 2013)
Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli ... |
Article
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
(American Society for Microbiology, 2013)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ... |
Article
Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study
(Public Library of Science (PLoS), 2013)
Introduction: Statins have pleiotropic effects that could influence the prevention and outcome of some infectious ... |
Article
Spanish Multicenter Study of the Epidemiology and Mechanisms of Amoxicillin-Clavulanate Resistance in Escherichia coli
(American Society for Microbiology, 2012)
We conducted a prospective multicenter study in Spain to characterize the mechanisms of resistance to amoxicillin-clavu-lanate ... |
Article
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost
(American Society for Microbiology, 2012)
To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a ... |
Article
β-Lactam/β-Lactam Inhibitor Combinations for the Treatment of Bacteremia Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli: A Post Hoc Analysis of Prospective Cohorts
(Oxford University Press, 2012)
Background. Extended-spectrum ß-lactamase–producing Escherichia coli (ESBL-EC) is an important cause of invasive infections. ... |
Article
Virulence Profiles of Bacteremic Extended-Spectrum β-Lactamase-Producing Escherichia coli: Association with Epidemiological and Clinical Features
(Public Library of Science, 2012)
There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused ... |
Patent. Invention
Dispositivo y método para el estudio dinámico de biocapas sobre catéteres de uso médico
(Oficina Española de Patentes y Marcas (OEPM), 2011)
Dispositivo y método para el estudio dinámico de biocapas sobre catéteres de uso médico. El dispositivo permite la ... |
Article
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
(American Society for Microbiology, 2011)
This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ... |
Article
Klebsiella pneumoniae Strains Producing Extended-Spectrum B-Lactamases in Spain: Microbiological and Clinical Features
(American Society for Microbiology, 2011)
Extended-spectrum B-lactamases (ESBL) of the CTX-M, SHV, and TEM families were recognized in 76 (67%), 31 (27%), and 6 ... |
Article
Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6′)-Ib-cr
(American Society for Microbiology, 2011)
The accuracy of the MicroScan WalkAway, BD Phoenix, and Vitek-2 systems for susceptibility testing of quinolones and ... |
Article
Clinical Features of Infections and Colonization by Acinetobacter Genospecies 3
(American Society for Microbiology, 2010)
Two hundred twenty-one isolates of Acinetobacter baumannii and 15 of Acinetobacter genospecies 3 (AG3) were consecutively ... |
Article
Long-Term Control of Endemic Hospital-Wide Methicillin-Resistant Staphylococcus aureus (MRSA): The Impact of Targeted Active Surveillance for MRSA in Patients and Healthcare Workers
(Cambridge University Press, 2010)
To evaluate the long-term impact of successive interventions on rates of methicillin-resistant Staphylococcus aureus (MRSA) ... |
Article
Diversity of Escherichia coli Strains Producing Extended-Spectrum B-Lactamases in Spain: Second Nationwide Study
(American Society for Microbiology, 2010)
The prevalence of extended-spectrum -lactamase (ESBL)-producing Escherichia coli (ESBLEC) in Spain increased 8-fold from ... |
Article
Risk Factors and Prognosis of Nosocomial Bloodstream Infections Caused by Extended-Spectrum-B-Lactamase-Producing Escherichia coli
(American Society for Microbiology, 2010)
Extended-spectrum-B-lactamase (ESBL)-producing Escherichia coli (ESBLEC) is an increasing cause of community and nosocomial ... |
PhD Thesis
Bacteriemias por Escherichia coli productor de beta-lactamasas de espectro extendido epidemiología clínica y molecular
(2010)
Hasta hace poco las infecciones por Escherichia coli productor de BLEE eran infrecuentes, pero en los últimos años estamos ... |
Article
Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3
(American Society for Microbiology, 2009)
As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The ... |
Article
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
(American Society for Microbiology, 2009)
We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ... |
Article
Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate
(American Society for Microbiology, 2008)
Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first ... |
Article
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008)
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ... |
Article
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant ... |
PhD Thesis
Betalactamasas de espectro extendido en enterobacterias aisladas de muestras clínicas de hospitales españoles
(2007)
En 1985, se describió la primera betalactamasa de espectro extendido (BLEE). En España la primera BLEE fue descrita en ... |
PhD Thesis |
Article
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
(American Society for Microbiology, 2006)
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 ... |
Article
Characterization of a clinical isolate of Haemophilus influenzae with a high level of fluoroquinolone resistance
(Oxford University Press, 2006)
Haemophilus influenzae is one of the bacterial pathogens most likely to be involved in community-acquired respiratory ... |
PhD Thesis
Resistencia a quinolonas mediada por plásmido en enterobacteriaceae
(2006)
En 1998, se describió por primera vez resistencia a quinolonas transmisible horizontalmente mediante un plásmido conjugativo. ... |
Article
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
(American Society for Microbiology, 2005)
Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ... |
Article
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain
(American Society for Microbiology, 2005)
Clonal dissemination of extended-spectrum -lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae ... |
Article
Clinical features and epidemiology of acinetobacter baumanni colonization and infection in spanish hospitals
(SLACK, 2004)
OBJECTIVE: To investigate the clinical features and the epidemiology of Acinetobacter baumannii in Spanish hospitals. DESIGN: ... |
Article
Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and b-Lactams in Acinetobacter Genospecies 3
(American Society for Microbiology, 2004)
Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies ... |
Article
Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients
(American Society for Microbiology, 2004)
Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in nonhospitalize patients ... |
Article
Type 1 Integrons in Epidemiologically Unrelated Acinetobacter baumannii Isolates Collected at Spanish Hospitals
(American Society for Microbiology, 2004)
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Article
Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance
(American Society for Microbiology, 2003)
To investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various ... |
Article
Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa
(American Society for Microbiology, 2003)
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters ... |
Article
Activities of ABT-773 against Listeria monocytogenes and coryneform bacteria of clinical interest
(American Society for Microbiology, 2003)
The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria ... |
Article
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) ... |
Article
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells
(American Society for Microbiology, 2002)
The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells ... |
PhD Thesis
Mecanismos de resistencia a Carbapenemas en cepas clínicas de Acinetobacter baumannii
(2001)
En los últimos años se ha producido un incremento significativo en el número de infecciones nosocomiales causadas por cepas ... |
Article
Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
(American Society for Microbiology, 2000)
The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. ... |
Article
Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles
(American Society for Microbiology, 2000)
Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, ... |
Article
Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae
(American Society for Microbiology, 1999)
Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less ... |
Article
Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells
(American Society for Microbiology, 1999)
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial ... |
Article
Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations
(American Society for Microbiology, 1999)
The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted ... |
Article
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
(American Society for Microbiology, 1999)
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) ... |
Article
In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria
(American Society for Microbiology, 1998)
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except ... |
Article
Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
(American Society for Microbiology, 1998)
The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of ... |
Article
Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells
(American Society for Microbiology, 1997)
The penetration of trovafloxacin into human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and ... |
Article
Antimicrobial susceptibility pattern of Corynebacterium striatum
(American Society for Microbiology, 1996)
The in vitro activities of 16 antimicrobial agents against 86 strains of Corynebacterium striatum were evaluated by ... |
PhD Thesis
Interacción de los macrólidos con la actividad de los leucocitos polimorfonucleares humanos
(1996)
Los antimicrobianos, además de su acción antibacteriana directa, pueden tener, en su interacción con las células fagocíticas, ... |
Article
Comparison of broth microdilution and E-test for susceptibility testing of Neisseria meningitidis
(American Society for Microbiology, 1996)
The susceptibilities of 54 clinical isolates of Neisseria meningitidis to penicillin, cefotaxime, ceftriaxone, cefepime, ... |
PhD Thesis
Penetración y actividad intracelular de cinco fluorquinolonas en leucocitos polimorfonucleares humanos
(1994)
La finalidad de este estudio ha sido determinar la capacidad de un grupo de quinolonas; fluorquinolonas, de penetrar en ... |
Article
Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes
(American Society for Microbiology, 1994)
The penetration of a new quinolone (BAY Y 3118) into human polymorphonuclear leukocytes (PMNs) was evaluated by a fluorometric ... |
Article
Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes
(American Society for Microbiology, 1993)
The penetration of fluconazole into human polymorphonuclear leukocytes (PMNs) and tissue culture epithelial cells (McCoy) ... |
PhD Thesis |
PhD Thesis
Efecto de inhibidores de betalactamasas en la actividad de los leucocitos polimorfonucleares humanos
(1992)
CONCLUSIONES 1. La exposición de S. aureus no productor de penicilinasa a concentraciones subinhibitorias de amoxicilina ... |
Article
Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells
(American Society for Microbiology, 1992)
The penetration of sparfloxacin into human neutrophils (PMN) and different tissue culture cells (HEp-2 and McCoy) was ... |
Article
Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells
(American Society for Microbiology, 1990)
The penetration of an optically active ofloxacin isomer [(-)-ofloxacin] into human neutrophils and different tissue culture ... |
PhD Thesis
Requerimientos opsónicos y adherencia a catéteres plásticos de estafilococo coagulasa negativo
(1985)
En las últimas décadas, las mayores innovaciones en el campo de la terapéutica se han centrado en el desarrollo de elementos ... |