idUS - Perfil del autor: Pascual Hernández, Álvaro

Nombre	Pascual Hernández, Álvaro
Departamento	Microbiología
Área de conocimiento	Microbiología
Categoría profesional	Catedrático de Universidad (V)
Correo electrónico	Solicitar

Nº publicaciones

129
Nº visitas

18765
Nº descargas

33909

Tipología

Orden

Publicaciones
Artículo Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model Rodríguez Ochoa, José Luis; Pérez Palacios, Patricia; Merino Bohórquez, Vicente; Ortiz Padilla, Miriam; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (Oxford University Press, 2024) Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ...
Artículo Activity of imipenem/relebactam and comparators against KPC-producing Klebsiella pneumoniae and imipenem-resistant Pseudomonas aeruginosa Delgado Valverde, María Mercedes; Portillo Calderón, Inés María; Alcalde Rico, Manuel; Conejo Gonzalo, Mª Carmen; Hidalgo, Carmen; Del Toro Esperón, Carlos; Pascual Hernández, Álvaro (Springer, 2023) Purpose: Relebactam is a novel β-lactamase inhibitor, which, when combined with imipenem/cilastatin, is active against ...
Tesis Doctoral Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems Díaz Díaz, Sara; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (2023) One of the major threats to human health is the emergence of antimicrobial resistance. Since the discovery of antimicrobials, ...
Artículo Interhospital Spread of blaVIM-1- and blaCTX-M-15-Producing K. pneumoniae ST15 on an IncR Plasmid in Southern Spain Pérez Palacios, Patricia; Gual de Torrella, Ana; Portillo Calderón, Inés María; Recacha Villamor, Esther; Franco Álvarez de Luna, Francisco; López Cerero, Lorena; Pascual Hernández, Álvaro (Multidisciplinary Digital Publishing Institute (MDPI), 2023) In 2014–2015, the main CTX-M-15- and OXA-48-producing clone in our region was ST15. Recently, K. pneumoniae ST15 isolates ...
Artículo Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial Sojo-Dorado, Jesus; Lopez-Hernandez, Inmaculada; Hernandez-Torres, Alicia; Retamar Gentil, Pilar; Merino de Lucas, Esperanza; Escola-Verge, Laura; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford Academic, 2023) Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections ...
Artículo In Vitro Activity of Cefiderocol Compared to Other Antimicrobials against a Collection of Metallo-Beta-Lactamase-Producing Gram-Negative Bacilli from Southern Spain Delgado Valverde, M.; Portillo Calderón, I.; Recacha, E.; Pérez Palacios, Patricia; Pascual Hernández, Álvaro (American Society for Microbiology, 2023) In this study, we aimed to comparatively evaluate the in vitro activity of cefiderocol versus other antimicrobials against ...
Tesis Doctoral Actividad de biocidas frente a aislados de Klebsiella pneumoniae productor de carbapenemasa Gual de Torrella Bennasar, Ana; Pascual Hernández, Álvaro; Fernández Cuenca, Felipe Manuel (2022) La diseminación de clones epidémicos de Klebsiella pneumoniae productor de carbapenemasa (Kp-PC) es un problema de salud ...
Tesis Doctoral Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico Portillo Calderón, Inés María; Docobo Pérez, Fernando; Pascual Hernández, Álvaro (2022) En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ...
Artículo Effect of Glycerol on Fosfomycin Activity against Escherichia coli Ortiz Padilla, Miriam; Portillo Calderón, Inés María; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ...
Artículo Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial Sojo Dorado, Jesús; López Hernández, Inmaculada; Rosso Fernández, Clara; Morales, Isabel; Palacios-Baena, Zaira R.; Hernández Torres, Alicia; Lobo Acosta, María Ángeles; Merino Bohórquez, Vicente; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Retamar Gentil, Pilar (Jama Nerwork Open, 2022) Importance The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant ...
Artículo Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents Salamanca Rivera, Elena; López Cerero, Lorena; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (American Society for Microbiology, 2022) Escherichia coli ST131 clade C is an important driver for fluoroquinolone resistance (FQ-R). We conducted a prospective ...
Artículo Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19 Cerrada Romero, Cristina; Berastegui-Cabrera, Judith; Camacho-Martínez, Pedro; Goikoetxea Aguirre, Josune; Pérez Palacios, Patricia; Santibáñez, Sonia; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo; Cordero Matia, María Elisa; Sánchez Céspedes, Javier (Nature Publishing Group, 2022) The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we ...
Artículo Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software Gato, Eva; Anantharajah, Ahalieyah; Arroyo, Manuel J.; Artacho, María José; Caballero, Juan de Dios; Candela, Ana; Pascual Hernández, Álvaro; Oviaño, María (Frontiers Media S.A., 2022) In this study, we evaluate the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry ...
Artículo Off-target effects of bacillus Calmette–Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19 Messina, Nicole L.; Germano, Susie; McElroy, Rebecca; Rudraraju, Rajeev; Bonnici, Rhian; Pittet, Laure F.; Toro López, María Dolores del; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (WILEY, 2022) Background and objectives. Because of its beneficial off-target effects against non-mycobacterial infectious diseases, ...
Artículo The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection Bleriot, Inés; Blasco, Lucía; Palacios, Olga; Fernández García, Laura; Ambroa, Antón; López, María; Pascual Hernández, Álvaro; Tomás, María (Nature Publishing Group, 2022) Since their discovery, toxin-antitoxin (TA) systems have captivated the attention of many scientists. Recent studies have ...
Artículo CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3 Cañada García, Javier E.; Moure, Zaira; Sola Campoy, Pedro J.; Delgado-Valverde, Mercedes; Cano, María E.; Gijón, Desirée; Pascual Hernández, Álvaro; Oteo Iglesias, Jesús (Frontiers Media S.A., 2022) Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the ...
Artículo Phenotypic and Genomic Comparison of Klebsiella pneumoniae Lytic Phages: vB_KpnM-VAC66 and vB_KpnM-VAC13 Pacios, Olga; Fernández García, Laura; Bleriot, Inés; Blasco, Lucía; Pascual Hernández, Álvaro; Tomás, María (MDPI, 2021) Klebsiella pneumoniae is a human pathogen that worsens the prognosis of many immuno compromised patients. Here, we annotated ...
Artículo Interplay between IncF plasmids and topoisomerase mutations conferring quinolone resistance in the Escherichia coli ST131 clone: stability and resistance evolution Rodríguez Martínez, José Manuel; López Cerero, Lorena; García-Duque, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (Springer, 2021) The Escherichia coli ST131 H30-Rx subclone vehicles CTX-M-15 plasmids and mutations in gyrA and parC conferring multidrug ...
Artículo In vitro activity of cefiderocol and comparators against isolates of Gram-negative bacterial pathogens from a range of infection sources: SIDERO‑WT‑2014−2018 studies in Spain Cercenado, Emilia; Cardenoso, Laura; Penin, Rocio; Longshaw, Christopher; Henriksen, Anne Santerre; Pascual Hernández, Álvaro (Science Direct, 2021) Objectives: The incidence of antimicrobial resistance in Europe is rising. Cefiderocol is approved in Eu- rope for treatment ...
Artículo Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress Recacha, E.; Machuca, J.; García Duque, A.; Docobo Pérez, Fernando; Blázquez, J.; Díaz Díaz, S.; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (American Society for Microbiology, 2021) Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ...
Artículo CON: carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant enterobacterales Rodríguez-Baño, Jesús; Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro (2021) Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone resistant ...
Artículo Reporting antimicrobial susceptibilities and resistance phenotypes in Staphylococcus spp.: a nationwide proficiency study Fernández-Cuenca, Felipe; López Hernández, Inmaculada; Cercenado, Emilia; Conejo Gonzalo, Mª Carmen; Tormo, Nuria; Gimeno, Concha; Pascual Hernández, Álvaro (Oxford University Press, 2021) Objectives To evaluate the proficiency of microbiology laboratories in Spain in antimicrobial susceptibility testing (AST) ...
Artículo Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnMVAC13 against clinical isolates of klebsiella pneumoniae Pacios, Olga; Fernández-García, Laura; Bleriot, Inés; Blasco, Lucía; González-Bardanca, Mónica; Pascual Hernández, Álvaro; Tomasa, María (American Society Microbiology, 2021) Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different strategies (resistance and ...
Artículo Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients Pierrotti, L. C; Pérez-Nadales, E.; Fernández-Ruiz, M.; Gutiérrez Gutiérrez, Belén; Tan, B. H.; Carratalà, J.; Cordero Matia, María Elisa; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Aguado, J. M. (Willey-Blackwell, 2021) Background Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for ...
Artículo Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae Ortiz Padilla, M.; Portillo Calderón, I.; De Gregorio Iaria, Belén; Blázquez, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (American Society for Microbiology, 2021) The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ...
Artículo Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients Riccio, Maria E.; Verschuuren, Tess; Conzelmann, Nadine; Martak, Daniel; Meunier, Alexandre; Salamanca, Elena; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Musicha, Patrick (Elsevier, 2021) Objectives: This study aimed to determine rates and risk factors of extended-spectrum b-lactamaseproducing Enterobacteriaceae ...
Artículo Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains Cebrero Cangueiro, Tania; Labrador Herrera, Gema; Pascual Hernández, Álvaro; Díaz, Caridad; Rodríguez-Baño, Jesús; Pachón Díaz, Jerónimo; Palacio, José P. del; Pachón Ibáñez, María Eugenia; Conejo Gonzalo, Mª Carmen (Frontiers Media, 2021) Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment ...
Artículo Propensity score and desirability of outcome ranking analysis of ertapenem for treatment of nonsevere bacteremic urinary tract infections due to extended-spectrum-beta-lactamase-producing enterobacterales in kidney transplant recipients Gutiérrez Gutiérrez, Belén; Pérez-Nadales, Elena; Pérez-Galera, Salvador; Cordero Matia, María Elisa; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; (American Society Microbiology, 2021) There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase ...
Artículo Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021) Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
Artículo Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gramnegative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases Álvarez-Marín, Rocío; López Cerero, Lorena; Palop-Borras, Begoña; Rojo-Martín, María Dolores; Ruiz-Sancho, Andrés; Herrero-Rodríguez, Carmen; García, María Victoria; Lazo-Torres, Ana María; López, Inmaculada; Martín-Hita, Lina; Nuño-Álvarez, Enrique; Sánchez-Yebra, Waldo; Galán-Sánchez, Fátima; Reguera-Iglesias, José María; Lepe Jiménez, José Antonio; Peñalva, Germán; Pascual Hernández, Álvaro; Cisneros, José Miguel (Oxford University Press, 2021) Background: Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide ...
Artículo Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences Álvarez-Marín, Rocío; Lepe Jiménez, José Antonio; Gasch-Blasi, Oriol; Rodríguez Martínez, José Manuel; Calvo-Montes, Jorge; Lara-Contreras, Rosario; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Jiménez-Mejías, Manuel E. (Elsevier, 2021) Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ...
Artículo Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial Marín Candón, Alicia; Rosso Fernández, Clara María; Bustos de Godoy, Natalia; López Cerero, Lorena; Gutiérrez Gutiérrez, Belén; López Cortés, Luis Eduardo; Merino Bohórquez, Vicente; Retamar Gentil, Pilar; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (BMJ Publishing Group, 2021) Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant ...
Tesis Doctoral Caracterización epidemiológica y clínica de la infección y colonización por Escherichia coli perteneciente al complejo clonal O25b/ST131 Morales Barroso, Isabel; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (2020) Introducción. Escherichia coli secuenciotipo 131 (ST131) es un clon que combina capacidad de propagación exitosa, resistencia ...
Artículo Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK Bleriot, Inés; Blasco, L.; Delgado Valverde, María Mercedes; Gual-de-Torrella, Ana; Ambroa, A.; Fernandez-Garcia, Laura; Pascual Hernández, Álvaro; Tomas, Maria (MDPI, 2020) Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a ...
Artículo In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens Blasco, Lucia; Ambroa, Anton; Trastoy, Rocio; Bleriot, Ines; Moscoso, Miriam; Fernández-Garcia, Laura; Pascual Hernández, Álvaro; Tomas, Maria (Nature Research, 2020) The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value of antimicrobials, which had ...
Artículo Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: the impact of cytomegalovirus disease and lymphopenia Pérez Nadales, Elena; Gutiérrez Gutiérrez, Belén; Natera, Alejandra M.; Abdala, Edson; Magalhães, Maira Reina; Mularoni, Alessandra; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Cordero Matia, María Elisa; Lepe Jiménez, José Antonio; REIPI/INCREMENT-SOT Investigators; (BMC, 2020) Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is ...
Artículo Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia Delgado Valverde, María Mercedes; Conejo, Mª del Carmen; Serrano, Lara; Fernández Cuenca, Felipe Manuel; Pascual Hernández, Álvaro (Oxford, 2020) BACKGROUND: Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli ...
Artículo Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination Martín Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020) Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
Artículo Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae Bleriot, Inés; Trastoy, Rocío; Blasco, Lucía; Fernández-Cuenca, Felipe; Ambroa, Antón; Fernández-García, Laura; Pascual Hernández, Álvaro; Tomás, María (2020) Klebsiella pneumoniae is the clinically most important species within the genus Klebsiella and, as a result of the continuous ...
Tesis Doctoral Supresion de la respuesta SOS como estrategia para la sensibilización de bacterias Gram-negativas resistentes a quinolonas. Recacha Villamor, Esther; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro (2019)
Artículo OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014-2015 Machuca, Jesús; López Cerero, Lorena; Fernández-Cuenca, Felipe; Mora-Navas, Laura; Mediavilla-Gradolph, Concepción; López-Rodríguez, Inmaculada; Pascual Hernández, Álvaro (Oxford University Press, 2019) The aim of this study was to characterize the population structure of 56 OXA-48-like-producing Klebsiella pneumoniae ...
Artículo Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence Morales Barroso, Isabel; López Cerero, Lorena; Navarro, María Dolores; Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Biomed Central, 2018) Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the ...
Tesis Doctoral Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro. Ballestero Téllez, Mónica; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (2018) El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ...
Artículo Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain Salavert, Miguel; Pascual Hernández, Álvaro; Cobo, Javier; Aragón, Belén; Maratia, Stefano; Aceituno, Susana; Grau, Santiago (Springer, 2018) Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated ...
Artículo Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli Merino Bohórquez, Vicente; Docobo Pérez, Fernando; Sojo Dorado, Jesús; Morales, Isabel; Lupión Mendoza, Carmen; Martín, D.; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Elsevier, 2018) Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ...
Artículo Duration of Colonization by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: a Prospective Cohort Study Rodríguez Revuelta, María; López Cerero, Lorena; Serrano, Lara; Luna Lagares, Salud; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford University Press, 2018) Duration of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated ...
Artículo Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients Torres, E.; López Cerero, Lorena; Navarro, M. D.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; (Elsevier, 2018) Objectives: The Escherichia coli O25b-associated ST131 clonal group was recently found to be prevalent in our area as a ...
Artículo Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. Pachón Ibáñez, María Eugenia; Labrador Herrera, Gema; Cebrero Cangueiro, Tania; Díaz, Caridad; Pascual Hernández, Álvaro; Conejo Gonzalo, Mª Carmen (Frontiers Media, 2018) Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of ...
Tesis Doctoral Tratamiento alternativo a los carbapenemas y desarrollo de un sistema pronóstico de puntuación en bacteriemias por enterobacterias productoras de beta-lactamasas de espectro extendido. Palacios Baena, Zaira Raquel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2017)
Tesis Doctoral Impacto de la concentración mínima inhibitoria (cmi) y de los puntos de corte clínicos (clsi y eucast) de las combinaciones betalactámicos / inhibidores de betalactamasas en el pronóstico de bacteriemias por enterobacteriaceae Delgado Valverde, María Mercedes; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2017) Los puntos de corte clínicos se utilizan para predecir la eficacia terapéutica de un antibiótico cuando se utiliza a la ...
Tesis Doctoral Prevalencia de Escherichia Coli o25b: h4-st131 productor o no de betalactamasa de espectro extendido (BLEE) en Sevilla Bellido Barquero, María del Mar; Pascual Hernández, Álvaro; López Cerero, Lorena (2017) Hasta finales de los años 90 K. pneumoniae era la principal enterobacteria implicada en la producción de estas enzimas, ...
Tesis Doctoral Colonización vagino-rectal y transmisión materno-neonatal de Enterobacteriaceae productores de betalactamasas de espectro extendido Jiménez Rámila, Carlos; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2017)
Artículo EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study Gutiérrez Gutiérrez, Belén; Sojo Dorado, Jesús; Bravo Ferrer, José; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (2017) Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. ...
Artículo Cellular Response to Ciprofloxacin in Low-Level Quinolone-Resistant Escherichia coli Machuca, Jesús; Recacha, Esther; Briales Martín, Alejandra; Díaz de Alba, Paula; Blázquez, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2017) Bactericidal activity of quinolones has been related to a combination of DNA fragmentation, reactive oxygen species (ROS) ...
Artículo Bacteraemia due to non-ESBL-producing Escherichia coli O25b:H4 sequence type 131: insights into risk factors, clinical features and outcomes Morales Barroso, Isabel; López Cerero, Lorena; Molina, José; Bellido, Mar; Navarro, María Dolores; Serrano, Lara; González-Galán, Verónica; Praena, Julia; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Elsevier, 2017) The epidemiology and outcomes of bloodstream infections (BSIs) caused by Escherichia coli ST131 isolates not producing ...
Artículo Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli Martín Gutiérrez, Guillermo; Rodríguez Beltrán, Jerónimo; Rodríguez Martínez, José Manuel; Costas, Coloma; Aznar Martín, Javier; Pascual Hernández, Álvaro; Blázquez, Jesús (American Society for Microbiology, 2016) Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently ...
Artículo A multinational, preregistered cohort study of β-lactam/β-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-β-lactamase-producing enterobacteriaceae Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Martínez Martínez, Luis; Cueto López, Marina de (American Society for Microbiology, 2016) The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem ...
Artículo Modelling the epidemiology of Escherichia coli ST131 and the impact of interventions on the community and healthcare centres Talaminos Barroso, Alejandro; López Cerero, Lorena; Calvillo Arbizu, Jorge; Pascual Hernández, Álvaro; Roa Romero, Laura María; Rodríguez-Baño, Jesús (Cambridge University Press, 2016) ST131 Escherichia coli is an emergent clonal group that has achieved successful worldwide spread through a combination of ...
Artículo Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010) López, M.; Rueda, A; Florido, J.P.; Blasco, L.; Gato, E.; Fernández García, L.; Pachón Díaz, Jerónimo; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (2016) Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by ...
Artículo Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance Rodríguez Martínez, José Manuel; Conejo Gonzalo, Mª Carmen; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (American Society for Microbiology, 2015) The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ...
Artículo Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem Conejo Gonzalo, Mª Carmen; Pascual Hernández, Álvaro; Otero, Jesús; Ortega, Adriana; Bartolomé, Rosa M.; Bou, Germán; Fernández Martínez, Marta; González López, Juan José (American Society for Microbiology, 2015) The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by ...
Tesis Doctoral Tratamiento de bacteriemias por enterobacterias productoras de β-lactamasas de espectro extendido la combinación de β-lactámicosinhibidores de β-lactamasas como alternativa a los carbapenemes. Proyecto INCREMENT Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2015) En los últimos años, la diseminación de las enterobacterias productoras de β-lactamasas de espectro extendido (E-BLEE) se ...
Tesis Doctoral Estudio clínico y epidemiológico de un brote nosocomial producido por klebsiella oxytoca productora de IMP-8 Vergara López, Salvador; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2015) Klebsiella oxytoca, al igual que K. pneumoniae, son dos patógenos humanos asociados a múltiples cuadros clínicos, pero ...
Artículo Fosfomycin versus meropenem in bacteraemic urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli (FOREST): study protocol for an investigator-driven randomised controlled trial Rosso Fernández, Clara; Sojo Dorado, Jesús; Barriga, Ángel; Lavín Alconero, Lucía; Palacios, Zaira; López Hernández, Inmaculada; Merino Bohórquez, Vicente; Cameán, Manuel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (BMJ Publishing Group, 2015) Introduction Finding therapeutic alternatives to carbapenems in infections caused by extended-spectrum β-lactamase-producing ...
Artículo Is reduced vancomycin susceptibility a factor associated with poor prognosis in MSSA bacteraemia? López-Cortes, Luis Eduardo; Velasco Ramírez, María del Carmen; Retamar Gentil, Pilar; Toro López, María Dolores del; Gálvez Acebal, Juan; Cueto López, Marina de; García Luque, Isabel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford University Press, 2015) Objectives: The known data about the influence of vancomycin MIC on Staphylococcus aureus bacteraemia are contradictory. ...
Tesis Doctoral Interacción de mecanismos plasmídicos y cromosómicos de resistencia a Quinolonas en Escherichia coli y su efecto en la resistencia, fitness y toxicidad celular Machuca Barcena, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (2014) Las fluoroquinolonas, junto a los beta-lactámicos, son los antimicrobianos de mayor uso clínico. Por tanto la aparición ...
Tesis Doctoral Estudio multicéntrico de bacteriemias por escherichia coli productor de betalactamasas de espectro extendido: factores de riesgo, características microbiológicas de impacto clínico Picón Toro, Encarnación; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2014) Esta tesis es el resultado de un estudio de investigación multicéntrico en el que participaron 13 hospitales y un centro ...
Artículo Global dissemination of a multidrug resistant Escherichia coli clone Petty, Nicola K.; Ben Zakour, Nouri; Stanton-Cook, Mitchell; Skippington, Elizabeth; Totsika, Makrina; Forde, Brian M.; Phan, Minh-Duy; Gomes Moriel, Danilo; Peters, Kate M.; Davies, Mark; Rogers, Benjamin A.; Dougan, Gordon; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Pitout, Johann D. D.; Upton, Mathew; Paterson, David L.; Walsh, Timothy; Schembri, Mark; Beatson, Scott (National Academy of Sciences, 2014) Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a ...
Artículo Epidemiologic and Clinical Impact of Acinetobacter baumannii Colonization and Infection: A Reappraisal Villar, Macarena; Cano, María Elicier; Gato, Eva; Garnacho Montero, José; Cisneros, José Miguel; Ruiz de Alegría, C.; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Lippincott Williams & Wilkins, 2014) Acinetobacter baumannii is one of the most important antibiotic-resistant nosocomial bacteria. We investigated changes in ...
Artículo Contribution of Efflux Pumps, Porins, and B-Lactamases to Multidrug Resistance in Clinical Isolates of Acinetobacter baumannii Rumbo, C.; Gato, E.; López, M.; Ruiz de Alegría, C.; Fernández-Cuenca, Felipe; Martínez-Martínez, Luis; Vila, Jordi; Pachón Díaz, Jerónimo; Cisneros, José Miguel; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Bou, Germán; Tomás, M. (American Society for Microbiology, 2013) Weinvestigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones ...
Artículo Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics Blanco, Jorge; Mora, Azucena; Mamani, Rosalia; López, Cecilia; Blanco, Miguel; Dahbi, Ghizlane; Herrera, Alexandra; Marzoa, Juan; Fernández, Val; Cruz, Fernando de la; Martínez-Martínez, Luis; Alonso, María Pilar; Nicolas-Chanoine, Marie-Hélène; Johnson, James R.; Johnston, Brian; López Cerero, Lorena; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (American Society for Microbiology, 2013) A total of 1,021 extended-spectrum- -lactamase-producing Escherichia coli (ESBLEC) isolates obtained in 2006 during a ...
Artículo Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-B-Lactamase- Producing Escherichia coli Retamar Gentil, Pilar; López Cerero, Lorena; Muniain Ezcurra, Miguel Angel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (American Society for Microbiology, 2013) We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to ...
Artículo Epidemiological and Clinical Complexity of Amoxicillin-Clavulanate- Resistant Escherichia coli Rodríguez-Baño, Jesús; Oteo, Jesús; Ortega, Adriana; Villar, Macarena; Conejo Gonzalo, Mª Carmen; Bou, Germán; Aranzamendi-Zaldumbide, Maitane; Cercenado, Emilia; Gurguí, Mercè; Martínez-Martínez, Luis; Merino, María; Rivera, Alba; Oliver, Antonio; Weber, Irene; Pascual Hernández, Álvaro; Bartolomé, Rosa M.; Gónzalez López, Juan José; Campos, José (American Society for Microbiology, 2013) Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli ...
Artículo Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model Docobo Pérez, Fernando; López Cerero, Lorena; López-Rojas, Rafael; Egea, P.; Domínguez-Herrera, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo (American Society for Microbiology, 2013) Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ...
Artículo Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study López Cortés, Luis Eduardo; Gálvez-Acebal, Juan; Toro López, María Dolores del; Velasco Ramírez, María del Carmen; Cueto López, Marina de; Caballero, Francisco J.; Muniain Ezcurra, Miguel Angel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Public Library of Science (PLoS), 2013) Introduction: Statins have pleiotropic effects that could influence the prevention and outcome of some infectious ...
Artículo Spanish Multicenter Study of the Epidemiology and Mechanisms of Amoxicillin-Clavulanate Resistance in Escherichia coli Ortega, Adriana; Oteo, Jesús; Aranzamendi-Zaldumbide, Maitane; Bartolomé, Rosa M.; Bou, Germán; Cercenado, Emilia; Conejo Gonzalo, Mª Carmen; González-López, Juan José; Marín, Mercedes; Martínez-Martínez, Luis; Marino, María; Ferran, Navarro; Oliver, Antonio; Pascual Hernández, Álvaro; Rivera, Alba; Rodríguez-Baño, Jesús; Weber, Irene; Aracil, Belén; Campos, José (American Society for Microbiology, 2012) We conducted a prospective multicenter study in Spain to characterize the mechanisms of resistance to amoxicillin-clavu-lanate ...
Artículo Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost Cauce, Alejandro; Briales, Alejandra; Rodríguez Rojas, Alexandro; Costas, Coloma; Pascual Hernández, Álvaro; Blázquez, Jesús (American Society for Microbiology, 2012) To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a ...
Artículo β-Lactam/β-Lactam Inhibitor Combinations for the Treatment of Bacteremia Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli: A Post Hoc Analysis of Prospective Cohorts Rodríguez-Baño, Jesús; Navarro, María Dolores; Retamar Gentil, Pilar; Picón, Encarnación; Pascual Hernández, Álvaro (Oxford University Press, 2012) Background. Extended-spectrum ß-lactamase–producing Escherichia coli (ESBL-EC) is an important cause of invasive infections. ...
Artículo Virulence Profiles of Bacteremic Extended-Spectrum β-Lactamase-Producing Escherichia coli: Association with Epidemiological and Clinical Features Rodríguez-Baño, Jesús; Mingorance, Jesús; Fernández Romero, Natalia; Serrano, Lara; López Cerero, Lorena; Pascual Hernández, Álvaro; ESBL-REIPI group (Public Library of Science, 2012) There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused ...
Patente. Invención Dispositivo y método para el estudio dinámico de biocapas sobre catéteres de uso médico Ojeda Monge, Antonio; García Luque, Isabel; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Conejo Gonzalo, Carmen; López Serrano, Jorge (Oficina Española de Patentes y Marcas (OEPM), 2011) Dispositivo y método para el estudio dinámico de biocapas sobre catéteres de uso médico. El dispositivo permite la ...
Artículo In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC Briales, Alejandra; Rodríguez Martínez, José Manuel; González Velasco, Carmen; Díaz de Alba, Paula; Domínguez Herrera, Juan M.; Pachón Díaz, Jerónimo; Pascual Hernández, Álvaro (American Society for Microbiology, 2011) This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ...
Artículo Klebsiella pneumoniae Strains Producing Extended-Spectrum B-Lactamases in Spain: Microbiological and Clinical Features Ruiz de Alegría, C.; Rodríguez-Baño, Jesús; Cano, M. E.; Hernández-Bello, José R.; Calvo, J.; Román, E.; Díaz, Miguel A.; Pascual Hernández, Álvaro; Martínez-Martínez, Luis (American Society for Microbiology, 2011) Extended-spectrum B-lactamases (ESBL) of the CTX-M, SHV, and TEM families were recognized in 76 (67%), 31 (27%), and 6 ...
Artículo Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6′)-Ib-cr Calvo, Jorge; Cano, María Elicier; Pitart, Cristina; Marco, Francesc; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Martínez Martínez, Luis (American Society for Microbiology, 2011) The accuracy of the MicroScan WalkAway, BD Phoenix, and Vitek-2 systems for susceptibility testing of quinolones and ...
Artículo Clinical Features of Infections and Colonization by Acinetobacter Genospecies 3 Molina, José; Cisneros, José Miguel; Fernández-Cuenca, Felipe; Rodríguez-Baño, Jesús; Ribera, Anna; Beceiro Casas, Alejandro; Martínez-Martínez, Luis; Pascual Hernández, Álvaro; Bou, Germán; Vila, Jordi; Pachón Díaz, Jerónimo (American Society for Microbiology, 2010) Two hundred twenty-one isolates of Acinetobacter baumannii and 15 of Acinetobacter genospecies 3 (AG3) were consecutively ...
Artículo Long-Term Control of Endemic Hospital-Wide Methicillin-Resistant Staphylococcus aureus (MRSA): The Impact of Targeted Active Surveillance for MRSA in Patients and Healthcare Workers Rodríguez-Baño, Jesús; García, Lola; Ramírez, Encarnación; Lupión Mendoza, Carmen; Muniain Ezcurra, Miguel Angel; Velasco Ramírez, María del Carmen; Gálvez-Acebal, Juan; Toro López, María Dolores del; Millán, Antonio B.; López Cerero, Lorena; Pascual Hernández, Álvaro (Cambridge University Press, 2010) To evaluate the long-term impact of successive interventions on rates of methicillin-resistant Staphylococcus aureus (MRSA) ...
Artículo Diversity of Escherichia coli Strains Producing Extended-Spectrum B-Lactamases in Spain: Second Nationwide Study Díaz, Miguel A.; Hernández-Bello, José R.; Rodríguez-Baño, Jesús; Martínez-Martínez, Luis; Calvo, Jorge; Blanco, Jorge; Pascual Hernández, Álvaro (American Society for Microbiology, 2010) The prevalence of extended-spectrum -lactamase (ESBL)-producing Escherichia coli (ESBLEC) in Spain increased 8-fold from ...
Artículo Risk Factors and Prognosis of Nosocomial Bloodstream Infections Caused by Extended-Spectrum-B-Lactamase-Producing Escherichia coli Rodríguez-Baño, Jesús; Picón, Encarnación; Gijón, Paloma; Hernández, José Ramón; Cisneros, José Miguel; Peña, Carmen; Almela, Manuel; Almirante, Benito; Grill, Fabio; Colomina, Javier; Molinos, Sonia; Oliver, Antonio; Fernández-Mazarrasa, Carlos; Navarro, Gemma; Coloma, Ana; López Cerero, Lorena; Pascual Hernández, Álvaro (American Society for Microbiology, 2010) Extended-spectrum-B-lactamase (ESBL)-producing Escherichia coli (ESBLEC) is an increasing cause of community and nosocomial ...
Tesis Doctoral Bacteriemias por Escherichia coli productor de beta-lactamasas de espectro extendido epidemiología clínica y molecular Navarro Sánchez-Ortiz, María Dolores; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2010) Hasta hace poco las infecciones por Escherichia coli productor de BLEE eran infrecuentes, pero en los últimos años estamos ...
Artículo Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3 Beceiro Casas, Alejandro; Pérez, Astrid; Fernández-Cuenca, Felipe; Martínez-Martínez, Luis; Pascual Hernández, Álvaro; Vila, Jordi; Rodríguez-Baño, Jesús; Cisneros, José Miguel; Pachón Díaz, Jerónimo; Bou, Germán (American Society for Microbiology, 2009) As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The ...
Artículo Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain Calvo, Jorge; Cano, María Elicier; Rodríguez Martínez, José Manuel; Agüero, J.; Pascual Hernández, Álvaro; Velasco Ramírez, María del Carmen; Francia, M. V.; Martínez Martínez, Luis (American Society for Microbiology, 2009) We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ...
Artículo Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate Fernández-Cuenca, Felipe; Pascual Hernández, Álvaro; Marti, Sara; Sánchez Céspedes, Javier; Blasco, M. Dolores; Ruiz, Marc; Espinal, Paula; Alba, Verónica (American Society for Microbiology, 2008) Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first ...
Artículo Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation Cueto López, Marina de; Rodríguez Martínez, José Manuel; Soriano Pérez, Manuel Jesús; López Cerero, Lorena; Venero Recio, José Luis; Pascual Hernández, Álvaro (American Society for Microbiology, 2008) The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ...
Artículo Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1 Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; González Velasco, Carmen; García Luque, Isabel; Cano, María Elicier; Martínez Martínez, Luis (American Society for Microbiology, 2007) The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant ...
Tesis Doctoral Betalactamasas de espectro extendido en enterobacterias aisladas de muestras clínicas de hospitales españoles Hernández Bello, José Ramón; Pascual Hernández, Álvaro; Martínez Martínez, Luis (2007) En 1985, se describió la primera betalactamasa de espectro extendido (BLEE). En España la primera BLEE fue descrita en ...
Tesis Doctoral Estudio de la colonización e infección por Staphylococcus aureus resistente a meticilina epidemiología, características clínicas y medidas de control Millán Rodríguez, Antonio Blas; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (2007)
Artículo Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes García Luque, Isabel; Ballesta, Sofía; Murillo del Castillo, Concepción; Perea Pérez, Evelio José; Pascual Hernández, Álvaro (American Society for Microbiology, 2006) The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 ...
Tesis Doctoral Resistencia a quinolonas mediada por plásmido en enterobacteriaceae Rodríguez Martínez, José Manuel; Martínez Martínez, Luis; Pascual Hernández, Álvaro (2006) En 1998, se describió por primera vez resistencia a quinolonas transmisible horizontalmente mediante un plásmido conjugativo. ...
Artículo Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase Pichardo, Cristina; Rodríguez Martínez, José Manuel; Pachón Ibáñez, María Eugenia; Conejo Gonzalo, Mª Carmen; Martínez Martínez, Luis; Pachón Díaz, Jerónimo; Pascual Hernández, Álvaro; (American Society for Microbiology, 2005) Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ...
Artículo Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum Î²-lactamases in Spain Hernández, J. R.; Martínez Martínez, Luis; Cantón, Rafael; Coque, T. M.; Pascual Hernández, Álvaro (American Society for Microbiology, 2005) Clonal dissemination of extended-spectrum -lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae ...
Artículo Clinical features and epidemiology of acinetobacter baumanni colonization and infection in spanish hospitals Rodríguez-Baño, Jesús; Cisneros, José Miguel; Fernández-Cuenca, Felipe; Ribera, Anna; Vila, Jordi; Pascual Hernández, Álvaro; Martínez-Martínez, Luis; Bou, Germán; Pachón Díaz, Jerónimo (SLACK, 2004) OBJECTIVE: To investigate the clinical features and the epidemiology of Acinetobacter baumannii in Spanish hospitals. DESIGN: ...
Artículo Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and b-Lactams in Acinetobacter Genospecies 3 Ribera, Anna; Fernández-Cuenca, Felipe; Beceiro Casas, Alejandro; Bou, Germán; Martínez-Martínez, Luis; Pascual Hernández, Álvaro; Cisneros, José Miguel; Rodríguez-Baño, Jesús; Pachón Díaz, Jerónimo; Vila, Jordi (American Society for Microbiology, 2004) Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies ...
Artículo Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients Rodríguez-Baño, Jesús; Dolores Navarro, María; Romero, Luisa; Martínez-Martínez, Luis; Muniain Ezcurra, Miguel Angel; Perea J., Evelio; Pérez Cano, Ramón; Pascual Hernández, Álvaro (American Society for Microbiology, 2004) Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in nonhospitalize patients ...
Artículo Type 1 Integrons in Epidemiologically Unrelated Acinetobacter baumannii Isolates Collected at Spanish Hospitals Ribera, Anna; Vila, Jordi; Fernández-Cuenca, Felipe; Martínez-Martínez, Luis; Pascual Hernández, Álvaro; Beceiro Casas, Alejandro; Bou, Germán; Cisneros, José Miguel; Pachón Díaz, Jerónimo; Rodríguez-Baño, Jesús (American Society for Microbiology, 2004)
Artículo Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance Doménech Sánchez, Antonio; Martínez Martínez, Luis; Hernández Allés, Santiago; Conejo Gonzalo, Mª Carmen; Pascual Hernández, Álvaro; Tomás, Juan M.; Albertí, Sebastián; Benedí, Vicente J. (American Society for Microbiology, 2003) To investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various ...
Artículo Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa Conejo Gonzalo, Mª Carmen; García Luque, Isabel; Martínez Martínez, Luis; Picabea de la Peña, Leandro; Pascual Hernández, Álvaro (American Society for Microbiology, 2003) The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters ...
Artículo Activities of ABT-773 against Listeria monocytogenes and coryneform bacteria of clinical interest Conejo Gonzalo, Mª Carmen; Martínez Martínez, Luis; Pascual Hernández, Álvaro; Suárez, Ana Isabel; Perea Pérez, Evelio José (American Society for Microbiology, 2003) The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria ...
Artículo Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production Martínez Martínez, Luis; Pascual Hernández, Álvaro; Conejo Gonzalo, Mª Carmen; García Luque, Isabel; Joyanes, Providencia; Doménech Sánchez, Antonio; Benedí, Vicente J. (American Society for Microbiology, 2002) The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) ...
Artículo Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells Pascual Hernández, Álvaro; Ballesta Mudarra, Sofía; García Luque, Isabel; Perea Pérez, Evelio José (American Society for Microbiology, 2002) The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells ...
Tesis Doctoral Mecanismos de resistencia a Carbapenemas en cepas clínicas de Acinetobacter baumannii Fernández Cuenca, Felipe Manuel; Martínez Martínez, Luis; Pascual Hernández, Álvaro (2001) En los últimos años se ha producido un incremento significativo en el número de infecciones nosocomiales causadas por cepas ...
Artículo Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes García Luque, Isabel; Pascual Hernández, Álvaro; Joyanes, Providencia; Perea Pérez, Evelio José (American Society for Microbiology, 2000) The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. ...
Artículo Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles Martínez Martínez, Luis; Conejo Gonzalo, Mª Carmen; Pascual Hernández, Álvaro; Hernández Allés, Santiago; Ramírez de Arellano Ramos, E.; Benedí, Vicente J.; Perea Pérez, Evelio José (American Society for Microbiology, 2000) Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, ...
Artículo Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae Martínez Martínez, Luis; Pascual Hernández, Álvaro; Hernández Allés, Santiago; Álvarez Díaz, Dolores; Suárez, Ana Isabel; Tran, John; Benedí, Vicente J.; Jacoby, George A. (American Society for Microbiology, 1999) Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less ...
Artículo Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells Pascual Hernández, Álvaro; García Luque, Isabel; Ballesta Mudarra, Sofía; Perea Pérez, Evelio José (American Society for Microbiology, 1999) The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial ...
Artículo Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations Martínez Martínez, Luis; Pascual Hernández, Álvaro; Conejo Gonzalo, Mª Carmen; Picabea de la Peña, Leandro; Perea Pérez, Evelio José (American Society for Microbiology, 1999) The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted ...
Artículo Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes Hernández Allés, Santiago; Benedí, Vicente J.; Martínez Martínez, Luis; Pascual Hernández, Álvaro; Aguilar, Alicia; Tomás, Juan M.; Albertí, Sebastián (American Society for Microbiology, 1999) We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) ...
Artículo In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria Martínez Martínez, Luis; Pascual Hernández, Álvaro; Suárez, Ana Isabel; Perea Pérez, Evelio José (American Society for Microbiology, 1998) The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except ...
Artículo Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains Martínez Martínez, Luis; García Luque, Isabel; Ballesta Mudarra, Sofía; Benedí, Vicente J.; Hernández Allés, Santiago; Pascual Hernández, Álvaro (American Society for Microbiology, 1998) The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of ...
Artículo Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells Pascual Hernández, Álvaro; Ballesta Mudarra, Sofía; Perea Pérez, Evelio José (American Society for Microbiology, 1997) The penetration of trovafloxacin into human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and ...
Artículo Antimicrobial susceptibility pattern of Corynebacterium striatum Martínez Martínez, Luis; Pascual Hernández, Álvaro; Bernard, Kathryn; Suárez, Ana Isabel (American Society for Microbiology, 1996) The in vitro activities of 16 antimicrobial agents against 86 strains of Corynebacterium striatum were evaluated by ...
Tesis Doctoral Interacción de los macrólidos con la actividad de los leucocitos polimorfonucleares humanos Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (1996) Los antimicrobianos, además de su acción antibacteriana directa, pueden tener, en su interacción con las células fagocíticas, ...
Artículo Comparison of broth microdilution and E-test for susceptibility testing of Neisseria meningitidis Pascual Hernández, Álvaro; Joyanes, Providencia; Martínez Martínez, Luis; Suárez, Ana Isabel; Perea Pérez, Evelio José (American Society for Microbiology, 1996) The susceptibilities of 54 clinical isolates of Neisseria meningitidis to penicillin, cefotaxime, ceftriaxone, cefepime, ...
Tesis Doctoral Penetración y actividad intracelular de cinco fluorquinolonas en leucocitos polimorfonucleares humanos Ballesta Mudarra, Sofía; Perea Pérez, Evelio José; Pascual Hernández, Álvaro (1994) La finalidad de este estudio ha sido determinar la capacidad de un grupo de quinolonas; fluorquinolonas, de penetrar en ...
Artículo Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes García Luque, Isabel; Pascual Hernández, Álvaro; Perea Pérez, Evelio José (American Society for Microbiology, 1994) The penetration of a new quinolone (BAY Y 3118) into human polymorphonuclear leukocytes (PMNs) was evaluated by a fluorometric ...
Artículo Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes Pascual Hernández, Álvaro; García Luque, Isabel; Conejo Gonzalo, Mª Carmen; Perea Pérez, Evelio José (American Society for Microbiology, 1993) The penetration of fluconazole into human polymorphonuclear leukocytes (PMNs) and tissue culture epithelial cells (McCoy) ...
Tesis Doctoral Actividad de antimicrobianos sobre biocapas bacterianas en biomateriales plásticos Ramírez de Arellano Ramos, Encarnación; Perea Pérez, Evelio José; Pascual Hernández, Álvaro (1992)
Tesis Doctoral Efecto de inhibidores de betalactamasas en la actividad de los leucocitos polimorfonucleares humanos Conejo Gonzalo, Mª Carmen; Perea Pérez, Evelio José; Pascual Hernández, Álvaro (1992) CONCLUSIONES 1. La exposición de S. aureus no productor de penicilinasa a concentraciones subinhibitorias de amoxicilina ...
Artículo Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells García Luque, Isabel; Pascual Hernández, Álvaro; Guzman Morgaz, Carmen; Perea Pérez, Evelio José (American Society for Microbiology, 1992) The penetration of sparfloxacin into human neutrophils (PMN) and different tissue culture cells (HEp-2 and McCoy) was ...
Artículo Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells Pascual Hernández, Álvaro; García Luque, Isabel; Perea Pérez, Evelio José (American Society for Microbiology, 1990) The penetration of an optically active ofloxacin isomer [(-)-ofloxacin] into human neutrophils and different tissue culture ...
Tesis Doctoral Requerimientos opsónicos y adherencia a catéteres plásticos de estafilococo coagulasa negativo Pascual Hernández, Álvaro; Perea Pérez, Evelio José (1985) En las últimas décadas, las mayores innovaciones en el campo de la terapéutica se han centrado en el desarrollo de elementos ...

Perfil del autor: Pascual Hernández, Álvaro

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