Perfil del autor: Ortega Sáenz, Patricia
Datos institucionales
| Nombre | Ortega Sáenz, Patricia |
| Departamento | Fisiología Médica y Biofísica |
| Área de conocimiento | Fisiología |
| Categoría profesional | Profesora Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
25
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Nº visitas
2680
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Nº descargas
2876
| Publicaciones |
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Tesis Doctoral
 Papel de la cadena de transporte de electrones mitocondrial en la respuesta aguda a hipoxia de los quimiorreceptores arteriales
(2023)
La respuesta ventilatoria aguda a la hipoxia es un reflejo mediado por las células glómicas quimiosensoras del cuerpo ... |
Artículo
 Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ... |
Artículo
Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice
(NATURE PUBLISHING GROUP, 2023)
The hypoxic ventilatory response (HVR) is a life-saving reflex, triggered by the activation of chemoreceptor glomus cells ... |
Artículo
Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
(National Academy of Sciences, 2022)
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with ... |
Artículo
Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices
(Cell Press, 2021)
Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. ... |
Artículo
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency
(Federation amer soc exp biol, 2021)
Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound ... |
Artículo
Lactate sensing mechanisms in arterial chemoreceptor cells
(2021)
Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative ... |
Artículo
Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α
(Frontiers Research Foundation, 2020)
Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ... |
| Tesis Doctoral |
Artículo
HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ... |
Artículo
Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
(Wiley, 2017)
Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ... |
Artículo
Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
(2016)
Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. ... |
Artículo
Carotid body oxygen sensing and adaptation to hipoxia
(Springer, 2015)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ... |
Artículo
Glucose sensing by carotid body glomus cells: potential implications in disease
(Frontiers Media, 2014)
The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ... |
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ... |
Artículo
Carotid body chemosensory responses in mice deficient of TASK channels
(2010)
Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) ... |
Patente
Células madre derivadas del cuerpo carotideo y usos de las mismas
(Oficina Española de Patentes y Marcas , 2009)
Células madre derivadas del cuerpo carotídeo y usos de las mismas caracterizadas porque son positivas para el marcador ... |
Artículo
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
(2008)
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the ... |
Ponencia
Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells
(John Wiley & Sons, 2006)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ... |
Artículo
Acute oxygen sensing in heme oxygenase-2 null mice
(2006)
Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to ... |
Tesis Doctoral
 Células neurosecretoras sensoras de oxígeno y glucosa
(2005)
El mantenimiento de un medio interno estable, u homesotasia, es especial para los seres vivos. Por ello existen sistemas ... |
Artículo
Regulation of oxygen sensing by ion channels
(2004)
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or ... |
Artículo
The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
(2004)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the ... |
Artículo
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ... |
Artículo
Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of ... |