Author profile: Orta Vázquez, Manuel Luis
Institutional data
Name | Orta Vázquez, Manuel Luis |
Department | Biología Celular |
Knowledge area | Biología Celular |
Professional category | Profesor Titular de Universidad |
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Statistics
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No. publications
18
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No. visits
3675
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No. downloads
11911
Publications |
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Article
![]() Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic ... |
Article
![]() ![]() Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ... |
Article
![]() In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and ... |
Final Degree Project
![]() Arteritis de Takayasu: posibles causas y bases celulares
(2022)
Con este trabajo se pretende dar a conocer en qué consiste la enfermedad Arteritis de Takayasu, sus bases celulares y las ... |
Article
![]() The Role of DNA Damage Response in Dysbiosis-Induced Colorectal Cancer
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
The high incidence of colorectal cancer (CRC) in developed countries indicates a predominant role of the environment as a ... |
Article
![]() Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
(Wiley, 2018)
Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ... |
Article
![]() The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions
(Impact Journals, 2018)
The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ... |
Article
![]() Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
(Elsevier, 2017)
Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ... |
Article
![]() RENEB accident simulation exercise
(Taylor & Francis LTD, 2017)
Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing ... |
Article
![]() Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
(MDPI AG, 2016)
Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ... |
Final Degree Project
![]() El uso de las TIC mediante el aprendizaje cooperativo : atendiendo a la diversidad en Educación Primaria
(2015)
Como educadores la primera cuestión que debemos plantearnos es qué es la Educación. Podemos definirla como la acción que ... |
Article
![]() Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
(2015)
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ... |
Article
![]() The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
(Oxford University Press, 2014)
Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ... |
Article
![]() Evaluating the cancer therapeutic potential of cardiac glycosides
(Hindawi Publishing Corporation, 2014)
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ... |
Article
![]() A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells
(Georg Thieme Verlag, 2013)
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ... |
Article
![]() 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
(Oxford University Press, 2013)
5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ... |
Article
![]() Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
(Oxford University Press, 2012)
Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end ... |
Article
![]() Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
(Elsevier, 2010)
Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results ... |