Author profile: Martínez de Pablos, Rocío
Institutional data
Name | Martínez de Pablos, Rocío |
Department | Bioquímica y Biología Molecular |
Knowledge area | Bioquímica y Biología Molecular |
Professional category | Catedrática de Universidad |
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Statistics
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No. publications
39
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No. visits
14235
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No. downloads
27041
Publications |
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Article
![]() Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ... |
Article
![]() Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection
(Elsevier, 2023)
Background Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to ... |
Article
![]() Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy and it is identified by the presence of ... |
Final Degree Project
![]() Influencia de la alimentación en el desarrollo de enfermedades neurodegenerativas
(2023)
Las enfermedades neurodegenerativas son enfermedades de carácter progresivo y de diversa naturaleza cuya prevalencia está ... |
Article
![]() ![]() Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
(Elsevier, 2023)
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ... |
Final Degree Project
![]() Microbiota y enfermedades neurodegenerativas: Efectos reales de probióticos y prebióticos
(2022)
El estudio de la microbiota es un campo en investigación que promete grandes avances en el tratamiento de enfermedades. ... |
Article |
Article
![]() Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ... |
Article
![]() Inflammatory Animal Models of Parkinson's Disease
(IOS Press, 2022)
Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis ... |
Article
![]() Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ... |
Article
![]() The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ... |
Article
![]() Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ... |
Final Degree Project
![]() Efectos del estrés sobre el sistema inmune
(2021)
El estrés se puede definir de forma global como el conjunto de reacciones fisiológicas que preparan al organismo para dar ... |
Article
![]() Editorial: Neurodegeneration: From Genetics to Molecules (Part II)
(Frontiers Media, 2021)
Among non-transmissible chronic diseases, neurodegenerative complications have become a big challenge in public health. ... |
Article
![]() Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ... |
Article
![]() Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ... |
Final Degree Project
![]() Efectos del ejercicio físico sobre el sistema inmune
(2020)
El sistema inmune (SI) es el principal encargado de mantener la homeostasis del organismo frente a amenazas externas y ... |
Final Degree Project
![]() Intolerancia a la lactosa y efectos en la microbiota
(2020)
La intolerancia a la lactosa es una enfermedad provocada por la mala absorción del disacárido lactosa y que produce ... |
PhD Thesis
![]() Implicación de las caspasas-3 y -8 en el trastorno del espectro autista y la enfermedad de Parkinson
(2020)
El trastorno del espectro autista (TEA) y la enfermedad de Parkinson (EP) son dos desórdenes neurológicos que presentan ... |
Article
![]() Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as ... |
Article
![]() Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ... |
PhD Thesis
![]() Metformin treatment decreases microglial activation in the in vivo lps model of parkinson's disease.
(2018)
Metformin is a widely used oral antidiabetic drug with known anti-inflammatory properties due to its action on AMP kinase. ... |
Article
![]() Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation
(Frontiers Media S.A., 2018)
Neuroinflammation is a pathological feature of quite a number of Central Nervous System diseases such as Alzheimer and ... |
Final Degree Project
![]() Influencia de la alimentación en el correcto funcionamiento del sistema inmune
(2018)
En base a la creciente incidencia de ciertas enfermedades autoinmunes y alergias alimentarias y a la coincidencia de este ... |
Article
![]() Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ... |
Article
![]() Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ... |
Article
![]() Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)
Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ... |
Article
![]() Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
(Elsevier, 2016)
The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and ... |
Article
![]() Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and ... |
Article
![]() Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ... |
PhD Thesis
![]() Efecto del tratamiento con metformina en el sistema dopaminérgico nigroestriado: posible implicación en la enfermedad de parkinson.
(2014)
La enfermedad de Parkinson (EP) es un desorden relacionado con la edad caracterizado por la degeneración progresiva de las ... |
Article
![]() Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
(BioMed Central, 2014)
Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ... |
Article
![]() Implantación del Plan de orientación y acción tutorial en la Facultad de Farmacia de la Universidad de Sevilla
(Universidad de Granada: Facultad de Farmacia, 2014)
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Article
![]() Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)
Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ... |
Article
![]() Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)
We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ... |
Article
![]() Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ... |
PhD Thesis |
Article
![]() Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex
(Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because ... |
PhD Thesis
![]() Implicación de la dopamina en los procesos degenerativos del sistema nigroestraido
(2005)
Nuestro grupo lleva años estudiando los mecanismos de degeneración del sistema dopaminérgico nigroestriado que podrían ... |