Perfil del autor: Luna Varo, Rosa María
Datos institucionales
| Nombre | Luna Varo, Rosa María |
| Departamento | Genética |
| Área de conocimiento | Genética |
| Categoría profesional | Profesora Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
19
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Nº visitas
3152
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Nº descargas
3275
| Publicaciones |
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Tesis Doctoral
 Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs
(2023)
Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del ... |
Artículo
  DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches ... |
Tesis Doctoral
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
(2021)
La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ... |
Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ... |
Artículo
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)
Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ... |
Tesis Doctoral
Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma
(2017)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ... |
Artículo
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ... |
Artículo
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
(Public Library of Science, 2016)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ... |
Artículo
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ... |
Artículo
R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity
(Public Library of Science, 2013)
To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ... |
Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ... |
Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ... |
Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ... |
Artículo
Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ... |
Artículo
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ... |
Artículo
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ... |
Artículo
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants
(American Society for Microbiology, 2006)
THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ... |
Artículo
Nab2p and the Thp1p-Sac3p Complex Functionally Interact at the Interface between Transcription and mRNA Metabolism
(Elsevier, 2003)
THP1 is a conserved eukaryotic gene whose null mutations confer, in yeast, transcription and genetic instability phenotypes ... |
Tesis Doctoral
Estudio sobre la función del gen tas14, inducible por estres salino y ácido abscisico en Lycopersicon esculentum
(1995)
La salinidad, presencia de altas concentraciones de sales en los suelos, constituye un problema creciente en la agricultura: ... |