idUS - Perfil del autor: Huertas Sánchez, Pablo

Nombre	Huertas Sánchez, Pablo
Departamento	Genética
Área de conocimiento	Genética
Categoría profesional	Profesor Titular de Universidad
Correo electrónico	Solicitar

Nº publicaciones

49
Nº visitas

8009
Nº descargas

7286

Tipología

Orden

Publicaciones
Tesis Doctoral Molecular basis of Aicardi-Goutières syndrome Moó Bajo, Andrea; Huertas Sánchez, Pablo; Jimeno González, Sonia (2023) DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous ...
Tesis Doctoral Unraveling the connection between centrosomes and the DNA damage response Rodríguez Real, Guillermo; Huertas Sánchez, Pablo; Romero Balestra, Fernando (2023) Centrosomes act as the major microtubule (MT) organizing centers (MTOC) in most animal cells. Structural or numerical defects in this organelle are associated with ...
Tesis Doctoral Non-canonical DNA structures in Double Strand Break repair Camarillo Daza, María Rosa; Huertas Sánchez, Pablo; Jimeno González, Sonia (2023) DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell ...
Artículo Centriolar Subdistal Appendages Promote Double-strand Break Repair Through Homologous Recombination Rodriguez Real, Guillermo; Domínguez Calvo, Andrés; Prados Carvajal, Rosario; Bayona Feliu, Aleix; Gomes Pereira, Sonia; Romero Balestra, Fernando; Huertas Sánchez, Pablo (1469-3178, 2023) The centrosome is a cytoplasmic organelle with roles in microtu-bule organization that has also been proposed to act as a ...
Artículo N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer García Vílchez, Raquel; Añazco Guenkova, Ana M.; López, Judith; Dietmann, Sabine; Tomé, Mercedes; Jimeno González, Sonia; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Huertas Sánchez, Pablo; Blanco, Sandra (Springer Nature, 2023) Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity ...
Artículo Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery Lebrón Romero, José Antonio; López López, Manuel; García Calderón, Clara Beatriz; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Rodik, Roman V; Kalchenko, Vitaly I.; Bernal Pérez, Eva; Moyá Morán, María Luisa; López-Cornejo, María del Pilar; Ostos Marcos, Francisco José (MDPI, 2021) The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried ...
Artículo ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair Jimeno González, Sonia; Prados Carvajal, Rosario; Fernández Ávila, María Jesús; Pinela Da Silva, Sonia Cristina; Silvestris, Domenico Alessandro; Endara Coll, Martin; Rodríguez Real, Guillermo; Domingo Prim, Judit; Mejías Navarro, Fernando; Romero Franco, Amador; Jimeno González, Silvia; Barroso, Sonia; Cesarini, Valeriana; Aguilera López, Andrés; Gallo, Angela; Visa, Neus; Huertas Sánchez, Pablo (Nature Publishing Group, 2021) The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
Artículo The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes Camarillo Daza, María Rosa; Jimeno González, Sonia; Huertas Sánchez, Pablo (Frontiers Media S.A., 2021) The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond ...
Artículo CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response Prados Carvajal, Rosario; Rodríguez Real, Guillermo; Gutiérrez Pozo, Gabriel; Huertas Sánchez, Pablo (Cold Spring Harbor Laboratory Press, 2021) In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...
Artículo TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin Romero Balestra, Fernando; Domínguez Calvo, Andrés; Wolf, Benita; Busso, Coralie; Buff, Alizée; Averink, Tessa; Lipsanen Nyman, Marita; Huertas Sánchez, Pablo; Rios Sánchez, Rosa M.; Gönczy, Pierre (eLife Sciences Publications, 2021) TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor ...
Artículo The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair Jimeno González, Sonia; Romero Balestra, Fernando; Huertas Sánchez, Pablo (Frontiers Media S.A., 2021) The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the ...
Artículo MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair Rivero Canalejo, Sabrina; Rodríguez Real, Guillermo; Marín, Inés; Huertas Sánchez, Pablo (Wiley-Blackwell, 2021) The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. ...
Artículo Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency Lebrón Romero, José Antonio; López-Cornejo, María del Pilar; García Dionisio, Elena; Huertas Sánchez, Pablo; García Calderón, Margarita; Moyá Morán, María Luisa; Ostos Marcos, Francisco José; López López, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2021) The interaction between calf-thymus DNA, ctDNA, and various single-chained surfactants with different functional groups ...
Tesis Doctoral Crosstalk between DNA end resection and RNA metabolism Prados Carvajal, Rosario; Huertas Sánchez, Pablo (2020) DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the ...
Tesis Doctoral Regulation of DNA end resection by cell stemness Checa Rodríguez, Cintia; Huertas Sánchez, Pablo (2020) The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic ...
Artículo UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jörg; Velpula, Bhagya Bhavana; Goergens, Jonas; Bustos, Matias A.; Checa Rodríguez, Cintia; Huertas Sánchez, Pablo (Elsevier, 2020) Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation ...
Artículo Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox Vítor, Alexandra C.; Huertas Sánchez, Pablo; Legube, Gaëlle; Almeida, Sérgio F. de (Frontiers Media, 2020) To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have ...
Artículo PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks Alonso de la Vega, Ignacio; Paz Cabrera, María Cristina; Rother, Magdalena B; Wiegant, Wouter W; Checa Rodríguez, Cintia; Hernández Fernaud, Juan Ramón; Huertas Sánchez, Pablo; Freire, Raimundo; Attikum, Haico van; Smits, Veronique A J (Oxford University Press, 2020) Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...
Artículo Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material Lebrón Romero, José Antonio; Ostos Marcos, Francisco José; López López, Manuel; Moyá Morán, María Luisa; Sales, Carlos; García, Encarnación; García Calderón, Clara Beatriz; García Calderón, Margarita; Peña Gómez, Mª José; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; López-Cornejo, María del Pilar (MDPI, 2020) Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation ...
Artículo ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection Mejías Navarro, Fernando; Rodríguez Leal, Jesús M.; Ramón, Javier; Camarillo Daza, María Rosa; Huertas Sánchez, Pablo (Public Library of Science, 2020) During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection ...
Tesis Doctoral Regulation of resection by chromatin associated proteins Mejías Navarro, Fernando; Huertas Sánchez, Pablo (2019) La molécula de ADN está permanentemente expuesta a múltiples fuentes de daño que ponen en peligro la integridad genómica. ...
Artículo EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks Domingo Prim, Judit; Endara Coll, Martin; Bonath, Franziska; Prados Carvajal, Rosario; Friedländer, Marc R.; Visa, Neus; Huertas Sánchez, Pablo; Jimeno González, Sonia (Nature Research, 2019) The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is ...
Artículo The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures Jimeno González, Sonia; Camarillo Daza, María Rosa; Mejías Navarro, Fernando; Fernández Ávila, Mª Jesús; Soria Bretones, Isabel; Prados Carvajal, Rosario; Huertas Sánchez, Pablo (Elsevier, 2018) DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination ...
Artículo Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 Hernández, Gonzalo; Ramirez, María José; Minguillón, Jordi; Quiles, Paco; Huertas Sánchez, Pablo; Prados Carvajal, Rosario (Nature Publishing Group, 2018) BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated ...
Artículo Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair Prados Carvajal, Rosario; Huertas Sánchez, Pablo; Gavish Izakson, Michal; Bhavana Velpula, Bhagya; Elkon, Ran (Oxford University Press, 2018) The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks ...
Artículo The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair Soria Bretones, Isabel; Baranes Bachar, Keren; Huertas Sánchez, Pablo; Levy Barda, Adva; Oehler, Judith (Elsevier, 2018) Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. ...
Tesis Doctoral New insights into CtIP protein: expression in breast cancer and regulation by sumoylation Soria Bretones, Isabel; Huertas Sánchez, Pablo (2017) Las roturas de doble cadena representan el tipo más nocivo entre todas las posibles lesiones que pueden ocurrir en el ADN, ...
Tesis Doctoral Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN López Saavedra, Ana; Huertas Sánchez, Pablo (2017) DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous ...
Tesis Doctoral Control de la procesividad de la resección por las proteinas CTIP, BRCA1 y las topoisomerasas del tipo II Cruz García, Andrés; Huertas Sánchez, Pablo (2017) Las cadenas de ADN pueden sufrir roturas debido a la acción de agentes exógenos, principalmente mutágenos químicos o ...
Artículo Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer Rabinowicz, Noa; Mangala, Lingegowda S.; Brown, Kevin R.; Checa Rodríguez, Cintia; Castiel, Asher; Huertas Sánchez, Pablo (Impact Journals, 2017) Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
Artículo CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells Gómez Cabello, Daniel; Checa Rodríguez, Cintia; Abad, María; Serrano, Manuel; Huertas Sánchez, Pablo (Elsevier, 2017) Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). ...
Artículo DNA end resection requires constitutive sumoylation of CtIP by CBX4 Soria Bretones, Isabel; Cepeda García, Cristina; Checa Rodríguez, Cintia; Heyer, Vincent; Reina San Martín, Bernardo; Soutoglou, Evi; Huertas Sánchez, Pablo (Nature Publishing Group, 2017) DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and ...
Tesis Doctoral Regulación de la reparación de los cortes de doble cadena en el ADN: papel de la nedilación de proteínas Fernández Ávila, María Jesús; Huertas Sánchez, Pablo; Jimeno González, Sonia (2016) Las roturas de doble cadena del ADN son las lesiones más citotóxicas que pueden ocurrir en el ADN. Pueden ser reparadas ...
Artículo A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection López Saavedra, Ana; Gómez Cabello, Daniel; Domínguez Sánchez, María Salud; Mejías Navarro, Fernando; Fernández Ávila, María Jesús; Martínez Macías, María Isabel; Huertas Sánchez, Pablo (Nature Publishing Group, 2016) There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous ...
Artículo Speed matters: How subtle changes in DNA end resection rate affect repair Huertas Sánchez, Pablo; Cruz García, Andrés (Taylor & Francis, 2015) The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the ...
Artículo The COP9 signalosome is vital for timely repair of DNA double-strand breaks Meir, Michal; Galanty, Yaron; Fernández Ávila, María Jesús; Cruz García, Andrés; Huertas Sánchez, Pablo (Oxford University Press, 2015) The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response ...
Artículo Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice Jimeno González, Sonia; Fernández Ávila, María Jesús; Cruz García, Andrés; Cepeda García, Cristina; Gómez Cabello, Daniel; Huertas Sánchez, Pablo (Oxford University Press, 2015) DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different ...
Ponencia Sumoylation of CtIP controls DNA end resection Soria Bretones, Isabel; Hernández Pérez, Santiago; Freire, Raimundo; Huertas Sánchez, Pablo (2014) Double strand breaks (DSBs) can be repaired by two major mechanisms. Both ends can be simple re-joined with little or no ...
Artículo BRCA1 Accelerates CtIP-Mediated DNA-End Resection Cruz García, Andrés; López Saavedra, Ana; Huertas Sánchez, Pablo (Elsevier, 2014) DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher ...
Artículo Prognostic value of CtIP/RBBP8 expression in breast cancer Soria Bretones, Isabel; Ruíz Borrego, Manuel; Japón Rodríguez, Miguel Ángel; Huertas Sánchez, Pablo (Wiley Open Access, 2013) CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination ...
Artículo Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013) While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
Artículo New tools to study DNA double-strand break repair pathway choice Gómez Cabello, Daniel; Jimeno González, Sonia; Fernández Ávila, María Jesús; Huertas Sánchez, Pablo (2013)
Artículo CtIP Mutations Cause Seckel and Jawad Syndromes Qvist, Per; Huertas Sánchez, Pablo; Jimeno González, Sonia; Nyegaard, Mette; Hassan, Muhammad J.; Jackson, Stephen P. (Public Library of Science, 2011) Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. ...
Artículo DNA resection in eukaryotes: deciding how to fix the break Huertas Sánchez, Pablo (Natural Research, 2010) DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous ...
Artículo Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair Huertas Sánchez, Pablo; Jackson, Stephen P. (American Society for Biochemistry and Molecular Biology, 2009) In G0 and G1, DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G2, they are also repaired ...
Artículo The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008) The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
Artículo CDK targets Sae2 to control DNA-end resection and homologous recombination Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008) DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
Artículo An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006) THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
Tesis Doctoral Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae Huertas Sánchez, Pablo; Aguilera López, Andrés (2004) La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...

Perfil del autor: Huertas Sánchez, Pablo

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