Author profile: Fernández-Bolaños Guzmán, José María
Institutional data
Name | Fernández-Bolaños Guzmán, José María |
Department | Química Orgánica |
Knowledge area | Química Orgánica |
Professional category | Catedrático de Universidad |
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Publications |
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Article
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
(Elsevier, 2024)
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for ... |
Article
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
(MDPI, 2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial ... |
Article
N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease
(Elsevier, 2023)
The oxindole core is an important structural motif in many natural and synthetic substances with various biological ... |
Article
Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023)
Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ... |
Article
Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
(Taylor & Francis, 2023)
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ... |
Article
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ... |
Article
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022)
Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ... |
Patent. Invention
procedimiento para la extracción en hoja de olivo de oleuropeína en una fracción fenólica, composición alimentaria funcional y uso
(Oficina Española de Patentes y Marcas (OEPM)., 2022)
Procedimiento para la extracción en hoja de olivo de oleuropeína en una fracción fenólica, composición alimentaria funcional ... |
Article
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
(Taylor & Francis, 2022)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ... |
Article
Identification of an acetyl esterase in the supernatant of the environmental strain Bacillus sp. HR21-6
(Elsevier, 2022)
Bacillus sp. HR21-6 is capable of the chemo- and regioselective synthesis of lipophilic partially acetylated phenolic ... |
Article
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ... |
Article
Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ... |
Article
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
(Taylor and Francis Group, 2022)
The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ... |
Article
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
(Royal Society of Chemistry, 2022)
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ... |
Article
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ... |
Article
Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors
(Royal Society of Chemistry, 2021)
We have used the Cu(i)-catalyzed azide-alkyne Huisgen cycloaddition reaction to obtain two families of bivalent heterodimers ... |
Article
Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ... |
Article
Inhibitory effect of olive phenolic compounds isolated from olive oil by-product on melanosis of shrimps
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates ... |
Article
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ... |
Article
A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation
(MDPI, 2021)
Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) haveexhibited several beneficial effects ... |
Article
Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation
(MDPI, 2020)
Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ... |
Article
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study
(Elsevier, 2020)
Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included ... |
PhD Thesis
Síntesis y evaluación de nuevas moléculas multidiana en la prevención de enfermedades degenerativas
(2020)
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y evaluación de nuevos compuestos orgánicos como fármacos ... |
Article
Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance
(MDPI, 2020)
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ... |
Article
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease
(American Chemical Society, 2020)
Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ... |
Article
Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol
(Sage, 2020)
Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, ... |
Article
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
(American Chemical Society, 2020)
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ... |
Article
Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function
(Royal Society of Chemistry, 2020)
During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ... |
Article
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019)
Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ... |
Article
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019)
Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ... |
Article
Chemoenzymatic synthesis and radical scavenging of sulfated hydroxytyrosol, tyrosol, and acetylated derivatives
(American Chemical Society, 2019)
Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for ... |
Article
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ... |
Article
Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway
(Wiley, 2019)
Primary human keratinocytes are pretreated with HTy-Ac or HTy for 30 min and stimulated with IL-1β or Toll-like receptor ... |
Patent. Invention
Procedimiento para la obtención de secoiridoides dialdehídicos
(Oficina Española de Patentes y Marcas , 2018)
Procedimiento para la obtención de secoiridoides dialdehídicos.Esta invención se refiere un procedimiento para la obtención ... |
Patent. Invention
Procedimiento para la obtención de secoiridoides dialdehídicos
(Oficina Española de Patentes y Marcas , 2018)
Procedimiento para la obtención de secoiridoides dialdehídicos.Esta invención se refiere un procedimiento para la obtención ... |
PhD Thesis
Síntesis química y enzimática de biofenoles lipofilos del olivo con actividad antiinflamatoria. Optimización de la reacción de Krapcho
(2017)
En la presente Tesis Doctoral se ha realizado la síntesis de una serie de compuestos lipófilos, a partir de biofenoles ... |
Article
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
(Elsevier, 2017)
We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ... |
Article
Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
(Royal Society of Chemistry, 2017)
The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ... |
Patent. Invention
Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos. La presente invención describe derivados ... |
Patent. Invention
Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos. La presente invención ... |
Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Patent. Invention
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Patent. Invention
Nuevos antiiflamatorios basados en polifenoles del olivo
(Oficina Española de Patentes y Marcas (OEPM), 2016)
El objeto de la invención se centra en la síntesis por dos rutas alternativas del (3,4-dihidroxifenil)glicol (6), producto ... |
Article
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria
(Public Library of Science, 2016)
The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ... |
Patent. Invention
Procedimiento de estabilización de las aguas de procesado de semilla de Lupinus spp., extracción de alcaloides y su uso como biocida ecológico
(Oficina Española de Patentes y Marcas (OEPM), 2015)
La invención que se presenta pertenece al sector de la agroquímica y la agricultura y tiene como objeto proporcionar un ... |
Article
Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products
(Elsevier, 2015)
The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product ... |
Patent. Invention
Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación
(Oficina Española de Patentes y Marcas (OEPM), 2014)
Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4- dihidroxifenilglicol, ... |
PhD Thesis
Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas
(2014)
En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ... |
Patent. Invention
Compuestos bioactivos polifenólicos conteniendo azufre o selenio y sus usos
(Oficina Española de Patentes y Marcas (OEPM), 2013)
Compuestos bioactivos polifenólicos conteniendo azufre o selenio y sus usos. La invención se refiere a compuestos que ... |
PhD Thesis
Síntesis de compuestos organoselénicos derivados del hidroxitirosol. Determinación de su actividad como antioxidantes
(2012)
1. Introducción Los polifenoles son una amplia familia de compuestos que se encuentran, entre otros alimentos, en la fruta, ... |
Article
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
(Royal Society of Chemistry, 2011)
We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ... |
PhD Thesis
Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos
(2007)
En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ... |
PhD Thesis
Sulfoazúcares, sulfoglicolípidos y taurinas N-sustituidas
(2001)
En esta Tesis Doctoral se han preparado C-sulfoazúcares y C-sulfopolioles que contienen un grupo sulfonato (SO3M) en ... |
PhD Thesis
Tioaminoazúcares y derivados. El grupo tiocarbamato como isotiocianato latente
(2000)
Dentro de un contexto general sobre síntesis de derivados de carbohidratos, mono-, di y oligosacáridos funcionalizados con ... |
PhD Thesis
Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas
(1999)
La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ... |
Article |
PhD Thesis
Síntesis de tioaminoazúcares y sulfoaminoazúcares
(1994)
En esta tesis se describe la preparación de una serie de nuevos tioaminoazúcares por reacción de desplazamiento nucleófilo ... |
PhD Thesis |
PhD Thesis |
PhD Thesis |