Author profile: Fernández Fernández, Inmaculada
Institutional data
Name | Fernández Fernández, Inmaculada |
Department | Química Orgánica y Farmaceútica |
Knowledge area | Química Orgánica |
Professional category | Catedrática de Universidad |
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Publications |
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Article
Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
(Elsevier, 2024)
Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ... |
Article
(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved
(Royal Society of Chemistry, 2023)
The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ... |
PhD Thesis
Derivados de d-Galactosa como antagonistas de los receptores NK1 de interés terapéutico: aproximaciones al diseño de nuevos nanosistemas teranósticos
(2023)
A pesar de los enormes esfuerzos tanto económicos como científicos invertidos en la lucha contra el cáncer, éste sigue ... |
Article
Synthesis and characterization of enantiopure chiral NH2/SO palladium complexes
(Royal Society of Chemistry, 2023)
A series of enantiopure chiral NH2/SO palladium complexes have been synthesised with high yields by treating the corresponding ... |
PhD Thesis
Diseño y síntesis de nuevos agentes quimioterápicos: receptores acoplados a proteína G (NK1 y CB2) y factores de transcripción (Nrf2 y STAT3) como dianas terapéuticas
(2022)
El cáncer es una enfermedad de gran impacto sanitario, económico y social en la población, para la que aún no se dispone ... |
Article
Benzothiazole Derivatives Endowed with Antiproliferative Activity in Paraganglioma and Pancreatic Cancer Cells: Structure–Activity Relationship Studies and Target Prediction Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The antiproliferative effects played by benzothiazoles in different cancers have aroused the interest for these molecules ... |
Article
Biologically Relevant Micellar Nanocarrier Systems for Drug Encapsulation and Functionalization of Metallic Nanoparticles
(MDPI, 2022)
The preparation of new and functional nanostructures has received more attention in the scientific community in the past ... |
Article
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
(Elsevier, 2022)
The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated ... |
Article
Immunomodulatory Effects of (R)-Sulforaphane on LPS-Activated Murine Immune Cells: Molecular Signaling Pathways and Epigenetic Changes in Histone Markers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the ... |
Article
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
(American Chemical Society, 2021)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ... |
Article
Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization
(Taylor and Francis Group, 2020)
Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications ... |
Article
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
(Royal Society of Chemistry, 2019)
An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has ... |
Article
Steric Tuning of Sulfinamide/Sulfoxides as Chiral Ligands with C1, Pseudo-meso, and Pseudo‑C2 Symmetries: Application in Rhodium(I)-Mediated Arylation
(ACS, 2019)
A new family of sulfinamide/sulfoxide derivatives was synthesized as chiral bidentate ligands by stereoselective additions ... |
Final Degree Project
Evolución y desarrollo de los complejos de rutenio como agentes antitumorales
(2019)
En este trabajo se presenta una revisión sobre la evolución y desarrollo de los complejos de rutenio usados en terapia ... |
Article
Synthesis and Characterization of New Biocompatible Amino Amphiphilic Compounds Derived from Oleic Acid as Nanovectors for Drug Delivery
(MDPI, 2019)
Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These ... |
Final Degree Project
Cisplatino y análogos. Visión actual y perspectiva de futuro
(2018)
En este trabajo se presenta un resumen sobre la evolución, desarrollo de estructuras y actividad de diversos ... |
Article
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
(Wiley Online Library, 2018)
An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed ... |
Article
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
(Elsevier, 2018)
Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial ... |
PhD Thesis |
Patent. Invention
Antagonistas de los receptores nk1 derivados de hidratos de carbono, metodo de obtencion y uso medico
(Oficina Española de Patentes y Marcas (OEPM), 2017)
Antagonistas de los receptores NK1 derivados de hidratos de carbono, método de obtención y uso médico. La presente invención ... |
Final Degree Project
Diseño y síntesis de nuevos ligandos quirales bidentados sulfinamido/olefina: aplicaciones en catálisis asimétrica
(2017)
En el proceso de desarrollo de una molécula de interés farmacéutico, industrial, cosmético o agroalimentario, se plantean ... |
Final Degree Project
Síntesis enantioselectiva de n-alquil 1-aril-1-etilaminas de interés farmacológico
(2017)
En los últimos tiempos, se ha puesto de manifiesto la importancia de las aminas quirales como parte de la estructura de ... |
Article
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
(Elsevier, 2017)
A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ... |
Article
Sulfinamide Phosphinates as Chiral Catalysts for the Enantioselective Organocatalytic Reduction of Imines
(American Chemical Society, 2016)
A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from ... |
Article
Pseudo enantiomeric mixed s/p ligands derived from carbohydrates for the 1,4-addition of phenyl boronic acid to cyclohexenone
(Royal Society of Chemistry, 2016)
The application of phosphinite-thioglycosides and phosphine-thioglycosides ligands in the Rh(I)-catalyzed 1,4-addition of ... |
Final Degree Project
Síntesis enantioselectiva de un nuevo análogo del sulforafano
(2016)
El sulforafano [(RS)-1-isocianato-4-(metilsulfinil)-butano], una molécula quiral caracterizada por contener los grupos ... |
Final Degree Project
Síntesis estereoselectiva de nuevos inhibidores de la agregación plaquetaria
(2016)
Chirality is a feature instrinsically linked to life. For this reason, the use of stereochemically pure compounds presents ... |
Article
Studies on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer
(Royal Society of Chemistry, 2015)
A detailed study on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides is reported. It has been shown that ... |
Article
Synthesis of 1D-glyconanomaterials by a hybrid noncovalent–covalent functionalization of single wall carbon nanotubes: a study of their selective interactions with lectins and with live cells
(Royal Society of Chemistry, 2015)
To take full advantage of the remarkable applications of carbon nanotubes in different fields, there is a need to develop ... |
Article
Síntesis estereoselectiva de una nueva familia de beta -aminoésteres de interés farmacológico como inhibidores potenciales de la agregación plaquetaria.
(Universidad pablo de Olavide, 2015)
Motivación: La utilización de compuestos estereoquímicamente puros presenta numerosas ventajas frente al uso de racematos ... |
PhD Thesis
Derivados quirales de azufre y de fósforo: síntesis y aplicaciones en catálisis asimétrica
(2014)
El trabajo presentado en esta Tesis Doctoral forma parte de un proyecto de investigación más amplio desarrollado a lo largo ... |
Article
DMAP-Catalysed Sulfinylation of Diacetone-D-Glucose: Improved Method for the Synthesis of Enantiopure tert-Butyl Sulfoxides and tert-Butanesulfinamide
(Wiley Online Library, 2014)
An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. ... |
Patent. Invention
Compuestos derivados de sulforafano, método de obtención y su uso médico, alimenticio y cosmético
(Oficina Española de Patentes y Marcas (OEPM)., 2014)
Compuestos derivados de sulforafano, método de obtención y su uso médico, alimenticio y cosméticoLa presente invención ... |
Article
Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activationof the Nrf2 transcription factor and selective cytotoxic activity
(Elsevier, 2014)
Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with ... |
Article
Proline-coated gold nanoparticles as a highly efficient nanocatalyst for the enantioselective direct aldol reaction in water
(Royal Society of Chemistry, 2013)
Reported is an efficient approach to the synthesis of water-soluble proline-coated gold nanoparticles through a place ... |
PhD Thesis
Nanotubos de carbono biocampatibles, síntesis y aplicaciones en biomedicina
(2012)
Considerando todo lo comentado anteriormente, el planteamiento general de esta Tesis Doctoral ha consistido en la síntesis ... |
Article
Chiral sulfur derivatives in the allylation of acyl hydrazones: C 2-symmetric bis-sulfinamides as enhanced chiral organic promoters
(Royal Society of Chemistry, 2010)
Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl ... |
PhD Thesis |
Article
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
(Springer, 2010)
We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ... |
Patent. Invention
Neoglicolipidos, sus agregados con nanotubos de carbono, procedimiento de obtencion y aplicaciones
(Oficina Española de Patentes y Marcas , 2009)
La presente invención se refiere a un glicolípido de fórmula (I) en la que R es un carbohidrato seleccionado entre un ... |
Article
Tailoring carbon nanotube surfaces with glyconanorings: New bionanomaterials with specific lectin affinity
(Royal Society of Chemistry, 2009)
Remarkably stable, water-soluble glyconanoring-coated SWCNTs were prepared by self organization and photopolymerization ... |
Article
New sulfur-phosphine ligands derived from sugars: synthesis and application in palladium-catalyzed allylic alkylation and in rhodium asymmetric hydrogenation
(Arkat USA, 2008)
An efficient route to mixed phosphine / thioglycoside ligands type IV starting from glucose pentaacetate is reported. In ... |
Patent. Invention
Fosfinitos tioglicosidos, procedimiento de preparación y utilización como nuevos ligandos en catálisis asimétrica.
(Oficina Española de Patentes y Marcas , 2007)
Fosfinitos tioglicósidos, procedimiento de preparación y utilización como nuevos ligandos en catálisis asimétrica.Se ... |
PhD Thesis |
Article
Phosphinite Thioglycosides Derived from Natural D-Sugars as Useful P/S Ligands for the Synthesis of Both Enantiomers in Palladium-Catalyzed Asymmetric Substitution
(Georg Thieme Verlag, 2005)
Phosphinite thioglycosides I for which a modular synthetic approach is reported, were found highly efficient catalyst ... |
PhD Thesis |
Patent. Invention
Procedimiento para la preparación de fosfinas y óxidos de fosfinas quirales a partir de fosfinatos de di-O-aquiliden y di-O- ariliden-α-D-glucofuranosilo.
(Oficina Española de Patentes y Marcas (OEPM)., 2000)
Procedimiento para la preparación de fosfinas y óxidos de fosfinas quirales a partir de fosfinatos de di-O-aquiliden y ... |
PhD Thesis
Nuevas aplicaciones de N-sulfiniliminas: síntesis de aziridinas y aminoalcoholes ópticamente puros
(1999)
Nos propusimos como objetivos de esta memoria los siguientes:1) Síntesis estereoselectivas de N- sulfiniliminas con distintos ... |
PhD Thesis |
PhD Thesis |