idUS - Author profile: Fernández-Chacón, Rafael

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Name	Fernández-Chacón, Rafael
Department	Fisiología Médica y Biofísica
Knowledge area	Fisiología
Professional category	Catedrático de Universidad
E-mail	Request

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Publications
PhD Thesis Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos Mesa Cruz, Cristina; Fernández-Chacón, Rafael; Nieto González, José Luis (2023) La cochaperona sináptica Cysteine String Protein CSP /DNAJC5) se ha implicado en la patogénesis de enfermedades ...
PhD Thesis Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5 Valenzuela Villatoro, Marina; Fernández-Chacón, Rafael; García-Junco Clemente, Pablo (2019) Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying ...
Article Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits Ortega de San Luís, Clara; Sánchez García, Manuel A.; Nieto González, José Luis; García-Junco Clemente, Pablo; Montero Sánchez, Adoración; Fernández-Chacón, Rafael; Pascual, Alberto (Anatomical Society of Great Britain and Ireland, 2018) The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently ...
PhD Thesis Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA). Martínez López, José Antonio; Fernández-Chacón, Rafael; Nieto González, José Luis (2017) Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. ...
Article Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2 Lavado-Roldán, Ángela; Fernández-Chacón, Rafael (Public Library of Science, 2016) One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. ...
Article A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss Nieto González, José Luis; Fernández-Chacón, Rafael; Servián Morilla, Emilia; Rivero, María C; Cabrera Serrano, Macarena; Gómez-Sánchez, Leonardo (Wiley-Blackwell Publishing Ltd., 2016) Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and ...
PhD Thesis Identificación de una firma inmunohistoquímica con valor predictivo en el carcinoma infiltrante de mama de tipo no especial (NST) Macías García, Laura; González Cámpora, Ricardo; Robles Frías, Antonio; Fernández-Chacón, Rafael (2015) Introducción: En la actualidad, el cáncer de mama es la neoplasia maligna más común en la mujer, siendo la causa principal ...
Article Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease Rozas Espadas, José Luis; Gómez-Sánchez, Leonardo; Tomás-Zapico, Cristina; Lucas Lozano, José J.; Fernández-Chacón, Rafael (2011) In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein ...
Article Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses García-Junco Clemente, Pablo; Cantero Nieto, Gloria; Gómez-Sánchez, Leonardo; Linares Clemente, Pedro; Martínez López, José Antonio; Luján, Rafael; Fernández-Chacón, Rafael (2010) The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that ...
Article Deletion of CASK in mice is lethal and impairs synaptic function Atasoy, Deniz; Schoch, Susanne; Ho, Angela; Nadasy, Krisztina A.; Liu, Xinran; Zhang, Weiqi; Mukherjee, Konark; Nosyreva, Elena D.; Fernández-Chacón, Rafael; Missler, Markus; Kavalali, Ege T.; Südhof, Thomas C. (2007) CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central ...
Article Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin Tabares, Lucía; Ruiz Laza, Rocío; Linares Clemente, Pedro; Gaffield, Michael A.; Álvarez de Toledo Naranjo, Guillermo; Fernández-Chacón, Rafael; Betz, William J. (2007) We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ...
Article CSP alpha-deficiency causes massive and rapid photoreceptor degeneration Schmitz, Frank; Tabares, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006) Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ...
Article The synaptic vesicle protein CSP alpha prevents presynaptic degeneration Fernández-Chacón, Rafael; Wolfel, M.; Nishimune, H.; Tabares, Lucía; Schmitz, Frank; Castellano-Munoz, M.; Rosenmund, Christian; Montesinos Gutiérrez, María Luz; Sudhof, TC (CELL PRESS, 2004) Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ...
Article Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2 Sorensen, Jakob B.; Fernández-Chacón, Rafael; Südhof, Thomas C.; Neher, Erwin (2003) We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the ...
Article Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules Riedel, Dietmar; Antonin, Wolfram; Fernández-Chacón, Rafael; Álvarez de Toledo Naranjo, Guillermo; Jo, Tobias; Geppert, Martin; Valentijn, Jack A.; Valentijn, Karin; Jamieson, James D.; Südhof, Thomas C.; Jahn, Reinhard (2002) Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as ...
Article Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1 Fernández-Chacón, Rafael; Shin, Ok-Ho; Königstorfer, Andreas; Matos, Maria F.; Meyer, Alexander C.; García, Jesús; Gerber, Stefan H.; Rizo, Josep; Südhof, Thomas C.; Rosenmund, Christian (2002) Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent ...
Article Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions Fernández-Chacón, Rafael; Südhof, Thomas C. (2000) In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking ...
Article Oxygen sensing by ion channels and chemotransduction in single glomus cells López Barneo, José; Montoro Laseca, Rafael Jesús; Ureña López, Juan; Fernández-Chacón, Rafael; Álvarez de Toledo Naranjo, Guillermo (1996) We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a ...
Article Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells Ureña López, Juan; Fernández-Chacón, Rafael; Rodríguez Benot, Alberto; Álvarez de Toledo Naranjo, Guillermo; López Barneo, José (1994) We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...