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Fijación del momento de la disolución del régimen económico matrimonial: Interpretación sustantiva y aspectos procesales. Comentario a la STS, Sala de lo Civil, núm. 215/2019, de 28 de mayo (RJ 2019, 2165)
(Aranzadi (Thomson Reuters), 2021-04-30) Flores Martín, Jackeline; Universidad de Sevilla. Departamento de Derecho Procesal
El Tribunal Supremo considera que el momento en que se produce la disolución matrimonial del régimen económico matrimonial de ganan-, a los efectos de proceder a su liquidación, es el de la fecha en que se declara el divorcio por sentencia firme. La duración del proceso matrimonial desde que se admite la demanda, o se dictan medidas provisionales, hasta que se dicta la sentencia, es ajena a la voluntad de las partes. Cuando media una separación de hecho seria y prolongada en el tiempo no se integran, en la comunidad de la sociedad, los bienes que, conforme a las del régimen económico serían gananciales. en especial cuando se trata de bienes adquiridos con el propio trabajo e industria de cada uno de los cónyuges y sin aportación del otro
Transumanesimo, vulnerabilità e dignità umana: il giurista di fronte alle sfide della rivoluzione tecnologica 4.0
(Universidad de Catanzaro, 2021-12) Llano-Alonso, Fernando Higinio; Universidad de Sevilla. Departamento de Filosofía del Derecho
The main aim of this article is to present a theoretical alternative to the dominant doctrine of justechnicism (whose postulates are in accordance with the foundations of legal formalism and the normativist view of law). This alternative is embodied in the defense of technological humanism, whose integrative plan makes it possible to reconcile scientifictechnological progress with the values and principles of humanist culture that make up the enlightened project of modernity.
Bacterial bioaugmentation for paracetamol removal from water and sewage sludge. Genomic approaches to elucidate biodegradation pathway
(Elsevier, 2024-12-05) Lara Moreno, Alba; Vargas Ordóñez, Antonio; Madrid, F.; Carlier, J. D.; Santos Morcillo, Juan Luis; Alonso Álvarez, Esteban; Morillo, E.; Universidad de Sevilla. Departamento de Microbiología y Parasitología; Universidad de Sevilla. Departamento de Biología Vegetal y Ecología; Universidad de Sevilla. Departamento de Química Analítica; Junta de Andalucía; Portuguese National Funds
Wastewater treatment plants (WWTPs) are recognized as significant contributors of paracetamol (APAP) into the environment due to their limited ability to degrade it. This study used a bioaugmentation strategy with Pseudomonas extremaustralis CSW01 and Stutzerimonas stutzeri CSW02 to achieve APAP biodegradation in solution in wide ranges of temperature (10–40 °C) and pH (5−9), reaching DT50 values < 1.5 h to degrade 500 mg L−1 APAP. Bacterial strains also mineralized APAP in solution (<30 %), but when forming consortia with Mycolicibacterium aubagnense HPB1.1, mineralization significantly increased (up to 74 % and 58 % for CSW01 +HPB1.1 and CSW02 +HPB1.1, respectively), decreasing DT50 values to only 1 and 9 days. Despite the complete degradation of APAP and its high mineralization, residual toxicity throughout the process was observed. Three APAP metabolites were identified (4-aminophenol, hydroquinone and trans-2-hexenoic acid) that quickly disappeared, but residual toxicity remained, indicating the presence of other non-detected intermediates. CSW01 and CSW02 degraded also 100 % APAP (50 mg kg−1) adsorbed on sewage sludge, with DT50 values of only 0.7 and 0.3 days, respectively, but < 15 % APAP was mineralized. A genome-based analysis of CSW01 and CSW02 revealed that amidases, deaminases, hydroxylases, and dioxygenases enzymes were involved in APAP biodegradation, and a possible metabolic pathway was proposed.
piRNAs are regulators of metabolic reprogramming in stem cells
(Springer Nature, 2024-09-27) Rojas Ríos, Patricia; Chartier, Aymeric; Enjolras, Camille; Cremaschi, Julie; Garret, Céline; Boughlita, Adel; Ramat, Anne; Simonelig, Martine; Universidad de Sevilla. Departamento de Genética; Centre national de la recherche scientifique (CNRS). France; Agence nationale de la recherche (ANR). France; Fondation pour la Recherche Médicale (FRM). France
Stem cells preferentially use glycolysis instead of oxidative phosphorylation and this metabolic rewiring plays an instructive role in their fate; however, the underlying molecular mechanisms remain largely unexplored. PIWI-interacting RNAs (piRNAs) and PIWI proteins have essential functions in a range of adult stem cells across species. Here, we show that piRNAs and the PIWI protein Aubergine (Aub) are instrumental in activating glycolysis in Drosophila female germline stem cells (GSCs). Higher glycolysis is required for GSC self-renewal and aub loss-of-function induces a metabolic switch in GSCs leading to their differentiation. Aub directly binds glycolytic mRNAs and Enolase mRNA regulation by Aub depends on its 5′UTR. Furthermore, mutations of a piRNA target site in Enolase 5′UTR lead to GSC loss. These data reveal an Aub/piRNA function in translational activation of glycolytic mRNAs in GSCs, and pinpoint a mechanism of regulation of metabolic reprogramming in stem cells based on small RNAs.
Evolutionary origin and population diversity of a cryptic hybrid pathogen
(Springer Nature, 2024-08-28) Steenwyk, Jacob L.; Knowles, Sonja; Bastos, Rafael W.; Balamurugan, Charu; Rinker, David; Mead, Matthew E.; Roberts, Christopher D.; Raja, Huzefa A.; Li, Yuanning; Colabardini, Ana Cristina; de Castro, Patricia Alves; Dos Reis, Thaila Fernanda; Gumilang, Adiyantara; Almagro-Molto, Maria; Alanio, Alexandre; Garcia-Hermoso, Dea; Delbaje, Endrews; Pontes, Lais; Pinzan, Camila Figueiredo; Schreiber, Angelica Zaninelli; Cánovas López, David; Sanchez Luperini, Rafael; Lagrou, Katrien; Torrado, Egidio; Rodrigues, Fernando; Oberlies, Nicholas H.; Zhou, Xiaofang; Goldman, Gustavo H.; Rokas, Antonis; Universidad de Sevilla. Departamento de Genética; National Science Foundation (NSF). United States; National Institute of Allergy and Infectious Diseases (NIAID); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); European Union (UE). H2020; Ministerio de Ciencia, Innovación y Universidades (MICINN). España; Agencia Estatal de Investigación. España
Cryptic fungal pathogens pose disease management challenges due to their morphological resemblance to known pathogens. Here, we investigated the genomes and phenotypes of 53 globally distributed isolates of Aspergillus section Nidulantes fungi and found 30 clinical isolates—including four isolated from COVID-19 patients—were A. latus, a cryptic pathogen that originated via allodiploid hybridization. Notably, all A. latus isolates were misidentified. A. latus hybrids likely originated via a single hybridization event during the Miocene and harbor substantial genetic diversity. Transcriptome profiling of a clinical isolate revealed that both parental subgenomes are actively expressed and respond to environmental stimuli. Characterizing infection-relevant traits—such as drug resistance and growth under oxidative stress—revealed distinct phenotypic profiles among A. latus hybrids compared to parental and closely related species. Moreover, we identified four features that could aid A. latus taxonomic identification. Together, these findings deepen our understanding of the origin of cryptic pathogens.
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