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dc.creatorContardi, M.es
dc.creatorAlfaro-Pulido, A.es
dc.creatorPicone, P.es
dc.creatorGuzmán-Puyol, S.es
dc.creatorGoldoni, L.es
dc.creatorBenítez Jiménez, José Jesúses
dc.creatorHeredia, Antonioes
dc.creatorBathel, M. J.es
dc.date.accessioned2019-08-20T10:25:11Z
dc.date.available2019-08-20T10:25:11Z
dc.date.issued2019-04
dc.identifier.citationContardi, M., Alfaro-Pulido, A., Picone, P., Guzmán-Puyol, S., Goldoni, L., Benítez Jiménez, J.J.,...,Bathel, M.J. (2019). Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications. Plos One, 14 (4), e0214956-1-e0214956-18.
dc.identifier.issn1932-6203es
dc.identifier.urihttps://hdl.handle.net/11441/88457
dc.description.abstractϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPlos One, 14 (4), e0214956-1-e0214956-18.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleLow molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applicationses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Ciencia de Materiales de Sevilla (ICMS) – CIC Cartujaes
dc.relation.publisherversionhttp://doi.org/10.1371/journal.pone.0214956es
dc.identifier.doi10.1371/journal.pone.0214956es
idus.format.extent18 p.es
dc.journaltitlePlos Onees
dc.publication.volumen14es
dc.publication.issue4es
dc.publication.initialPagee0214956-1es
dc.publication.endPagee0214956-18es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional