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The Nup84 complex coordinates the DNA damage response to warrant genome integrity


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dc.creator Gaillard, Hélène es
dc.creator Santos Pereira, José María es
dc.creator Aguilera López, Andrés es 2019-05-16T16:41:52Z 2019-05-16T16:41:52Z 2019
dc.identifier.citation Gaillard, H., Santos Pereira, J.M. y Aguilera López, A. (2019). The Nup84 complex coordinates the DNA damage response to warrant genome integrity. Nucleic Acids Research, 47 (8), 4054-4067.
dc.identifier.issn 0305-1048 es
dc.identifier.issn 1362-4962 es
dc.description.abstract DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to warrant genome integrity. Beyond their primary role in molecule transport, nuclear pore complexes (NPCs) function in other processes such as transcription, nuclear organization and DNA double strand break (DSB) repair. Here we found that the removal of UV-induced DNA lesions by nucleotide excision repair (NER) is compromised in the absence of the Nup84 nuclear pore component. Importantly, nup84Δ cells show an exacerbated sensitivity to UV in early S phase and delayed replication fork progression, suggesting that unrepaired spontaneous DNA lesions persist during S phase. In addition, nup84Δ cells are defective in the repair of replication-born DSBs by sister chromatid recombination (SCR) and rely on post-replicative repair functions for normal proliferation, indicating dysfunctions in the cellular pathways that enable replication on damaged DNA templates. Altogether, our data reveal a central role of the NPC in the DNA damage response to facilitate replication progression through damaged DNA templates by promoting efficient NER and SCR and preventing chromosomal rearrangements. es
dc.description.sponsorship European Research Council ERC2014 AdG669898 TARLOOP es
dc.description.sponsorship Ministerio de Economía y Competitividad BFU2016-75058-P es
dc.description.sponsorship Junta de Andalucía PA12-BIO1238 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Oxford University Press es
dc.relation.ispartof Nucleic Acids Research, 47 (8), 4054-4067.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.title The Nup84 complex coordinates the DNA damage response to warrant genome integrity es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) es
dc.relation.projectID ERC2014 AdG669898 TARLOOP es
dc.relation.projectID BFU2016-75058-P es
dc.relation.projectID PA12-BIO1238 es
dc.relation.publisherversion es
dc.identifier.doi 10.1093/nar/gkz066 es
idus.format.extent 14 p. es
dc.journaltitle Nucleic Acids Research es
dc.publication.volumen 47 es
dc.publication.issue 8 es
dc.publication.initialPage 4054 es
dc.publication.endPage 4067 es
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