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Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application

 

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Opened Access Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application
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Author: Havas, Fabien
Krispin, Shlomo
Meléndez Martínez, Antonio Jesús
Von Oppen-Bezalel, Liki
Department: Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal
Date: 2018
Published in: Journal of Toxicology, 2018, 5475784-.
Document type: Article
Abstract: The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin. Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern. However, since the interest in these compounds in the context of many applications is expanding, it is important to conduct studies aimed at assessing their safety. We present here results of in vitro cytotoxicity and genotoxicity studies, revealing no significant cytotoxic or genotoxic potential and of short- and long-term human in vivo skin compatibility studies with phytoene- and phytofluene-rich tomato and Dunaliella salina alga extracts, showing a lack of irritancy or sensitization reactions. These results support the safe use of phytoene- and phytofluene-rich products in human topical applications.
Cite: Havas, F., Krispin, S., Meléndez Martínez, A.J. y Von Oppen-Bezalel, L. (2018). Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application. Journal of Toxicology, 2018, 5475784-.
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URI: https://hdl.handle.net/11441/85830

DOI: 10.1155/2018/5475784

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This work is under a Creative Commons License: 
Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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