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dc.creatorJimeno González, Soniaes
dc.creatorCamarillo Daza, María Rosaes
dc.creatorMejías Navarro, Fernandoes
dc.creatorFernández Ávila, Mª Jesúses
dc.creatorSoria Bretones, Isabeles
dc.creatorPrados Carvajal, Rosarioes
dc.creatorHuertas Sánchez, Pablo
dc.date.accessioned2019-04-16T11:01:56Z
dc.date.available2019-04-16T11:01:56Z
dc.date.issued2018
dc.identifier.citationJimeno González, S., Camarillo Daza, M.R., Mejías Navarro, F., Fernández Ávila, M.J., Soria Bretones, I., Prados Carvajal, R. y Huertas Sánchez, P. (2018). The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures. Cell Reports, 24 (12), 3262-3273.
dc.identifier.issn2211-1247es
dc.identifier.urihttps://hdl.handle.net/11441/85720
dc.description.abstractDNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination (HR). The decision between these two routes of DNA repair is a key point of the DNA damage response (DDR) that is controlled by DNA resection. The core machinery catalyzing the resection process is well established. However, little is known about the additional requirements of DNA resection over DNA structures with high complexity. Here, we found evidence that the human helicase PIF1 has a role in DNA resection, specifically for defined DNA regions, such as those prone to form G-quadruplexes. Indeed, PIF1 is recruited to the site of DNA damage and physically interacts with proteins involved in DNA resection, and its depletion causes DNA damage sensitivity and a reduction of HR efficiency. Moreover, G4 stabilization by itself hampers DNA resection, a phenomenon suppressed by PIF1 overexpressiones
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofCell Reports, 24 (12), 3262-3273.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBRCA1es
dc.subjectDNA end resectiones
dc.subjectDNA recombinationes
dc.subjectDNA repaires
dc.subjectDSB repaires
dc.subjectG-quadruplexes
dc.subjectPIF1es
dc.titleThe Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structureses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.celrep.2018.08.047es
dc.identifier.doi10.1016/j.celrep.2018.08.047es
idus.format.extent11 p.es
dc.journaltitleCell Reportses
dc.publication.volumen24es
dc.publication.issue12es
dc.publication.initialPage3262es
dc.publication.endPage3273es

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