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Human Long Telomeres and Epigenetic Marks


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Author: Vega Palas, Miguel Ángel
Vaquero Sedas, María Isabel
Department: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Date: 2013
Published in: CellBio, 2 (2), 70-72.
Document type: Article
Abstract: We have read with interest the article “Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α” by Arnoult and colleagues [1]. This study focuses on human telomeric chromatin structure using different techniques like Chromatin Immunoprecipitation (ChIP), cytolocalization or RT-qPCR. However, it has been performed without taking into consideration the presence of Interstitial Telomeric Sequences (ITSs) in the human genome. Some of the conclusions of the article are undoubtedly clear but there are others that might be explained in alternative ways, considering the existence of ITSs. Following, we mention some comments that arise from this interesting article.
Cite: Vega Palas, M.Á. y Vaquero Sedas, M.I. (2013). Human Long Telomeres and Epigenetic Marks. CellBio, 2 (2), 70-72.
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DOI: 10.4236/cellbio.2013.22009

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