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Staphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studies


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dc.creator Kaasch, Achim es
dc.creator Barlow, Gavin es
dc.creator Edgeworth, Jonathan es
dc.creator Fowler, Vance es
dc.creator Hellmich, Martin es
dc.creator Rodríguez-Baño, Jesús es 2019-02-26T17:55:17Z 2019-02-26T17:55:17Z 2014
dc.identifier.issn 1532-2742 es
dc.description.abstract Objectives: Staphylococcus aureus bacteraemia is a common, often fatal infection. Our aim was to describe how its clinical presentation varies between populations and to identify common determinants of outcome. Methods: We conducted a pooled analysis on 3395 consecutive adult patients with S. aureus bacteraemia. Patients were enrolled between 2006 and 2011 in five prospective studies in 20 tertiary care centres in Germany, Spain, United Kingdom, and United States. Results: The median age of participants was 64 years (interquartile range 50–75 years) and 63.8% were male. 25.4% of infections were associated with diabetes mellitus, 40.7% were nosocomial, 20.6% were caused by methicillin-resistant S. aureus (MRSA), although these proportions varied significantly across studies. Intravenous catheters were the commonest identified infective focus (27.7%); 8.3% had endocarditis. Crude 14 and 90-day mortality was 14.6% and 29.2%, respectively. Age, MRSA bacteraemia, nosocomial acquisition, endocarditis, and pneumonia were independently associated with death, but a strong association was with an unidentified infective focus (adjusted hazard ratio for 90-day mortality 2.92; 95% confidence interval 2.33 to 3.67, p < 0.0001). Conclusion: The baseline demographic and clinical features of S. aureus bacteraemia vary significantly between populations. Mortality could be reduced by assiduous MRSA control and early identification of the infective focus. es
dc.description.sponsorship Junta de Andalucía PI 0185/2010 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher W.B. Saunders Co. Ltd. es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.subject Staphylococcus aureus es
dc.subject Bacteraemia es
dc.subject Mortality es
dc.subject Pooled analysis es
dc.title Staphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studies es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Medicina es
dc.relation.projectID PI 0185/2010 es
dc.identifier.doi 10.1016/j.jinf.2013.10.015 es Universidad de Sevilla. CTS 406: Estudio Enfermedades Infecciosas en la Practica Clínica es
idus.format.extent 18 es
dc.journaltitle The Journal of Infection es
dc.publication.volumen 68 es
dc.publication.issue 3 es
dc.publication.initialPage 242 es
dc.publication.endPage 251 es
dc.contributor.funder Junta de Andalucía
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