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BRCA1 Accelerates CtIP-Mediated DNA-End Resection


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Opened Access BRCA1 Accelerates CtIP-Mediated DNA-End Resection

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Author: Cruz García, Andrés
López Saavedra, Ana
Huertas Sánchez, Pablo
Department: Universidad de Sevilla. Departamento de Genética
Date: 2014
Published in: Cell Reports, 9, 451-459.
Document type: Article
Abstract: DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place.
Cite: Cruz García, A., López Saavedra, A. y Huertas Sánchez, P. (2014). BRCA1 Accelerates CtIP-Mediated DNA-End Resection. Cell Reports, 9, 451-459.
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DOI: 10.1016/j.celrep.2014.08.076

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