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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

 

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Opened Access Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder
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Author: Hmadcha, Abdelkrim
Aguilera, Yolanda
Lozano Arana, María Dolores
Mellado, Nuria
Sánchez, Javier
Moya, Cristina
Sánchez Palazón, Luis
Palacios Calvo, José
Antiñolo Gil, Guillermo
Soria Escoms, Bernat
Department: Universidad de Sevilla. Departamento de Cirugía
Date: 2016
Published in: Stem Cell Research, 16, 635-639.
Document type: Article
Abstract: From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B. Despite the translocation t(9;15)(q34.3;q14) detected in HVR2, all the 3 cell lines were characterised in vitro and in vivo as normal hESCs lines and were registered in the Spanish Stem Cell Bank.
Cite: Hmadcha, A., Aguilera, Y., Lozano Arana, M.D., Mellado, N., Sánchez, J., Moya, C.,...,Soria Escoms, B. (2016). Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder. Stem Cell Research, 16, 635-639.
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URI: https://hdl.handle.net/11441/82147

DOI: 10.1016/j.scr.2016.03.012

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