dc.creator | Silva, Sonia | es |
dc.creator | Altmannova, Veronika | es |
dc.creator | Luke Glaser, Sarah | es |
dc.creator | Henriksen, Peter | es |
dc.creator | Gallina, Irene | es |
dc.creator | Yang, Xuejiao | es |
dc.creator | Choudhary, Chunaram | es |
dc.creator | Luke, Brian | es |
dc.creator | Krejci, Lumir | es |
dc.creator | Lisby, Michael | es |
dc.date.accessioned | 2019-01-17T13:09:31Z | |
dc.date.available | 2019-01-17T13:09:31Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Silva, S., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X.,...,Lisby, M. (2016). Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes and Development, 30, 700-717. | |
dc.identifier.issn | 0890-9369 (impreso) | es |
dc.identifier.issn | 1549-5477 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/81686 | |
dc.description.abstract | Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance
processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1
as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere
maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork
structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the
ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and
suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize
atDNAdamage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken
together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication
stress, and telomere maintenance. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Cold Spring Harbor Laboratory Press | es |
dc.relation.ispartof | Genes and Development, 30, 700-717. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Homologous recombination | es |
dc.subject | Telomere maintenance | es |
dc.subject | Genome integrity | es |
dc.subject | DNA repair | es |
dc.subject | Mph1 | es |
dc.subject | Mte1 | es |
dc.title | Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | https://doi.org/10.1101/gad.276204.115 | es |
dc.identifier.doi | 10.1101/gad.276204.115 | es |
idus.format.extent | 18 p. | es |
dc.journaltitle | Genes and Development | es |
dc.publication.volumen | 30 | es |
dc.publication.initialPage | 700 | es |
dc.publication.endPage | 717 | es |