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The Multifarious Role of Microglia in Brain Metastasis


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dc.creator Sarmiento Soto, Manuel es
dc.creator Sibson, Nicola R. es 2019-01-16T13:00:24Z 2019-01-16T13:00:24Z 2018-11
dc.identifier.citation Sarmiento Soto, M. y Sibson, N.R. (2018). The Multifarious Role of Microglia in Brain Metastasis. Frontiers in Cellular Neuroscience, 12, 414-1-414-7.
dc.identifier.issn 1662-5102 es
dc.description.abstract The immune landscape in brain metastasis is a very heterogeneous framework. Amongst a broad plethora of cells within the tumor microenvironment, the presence of activated microglia has been perfectly described. The innate role of microglial cells is to detect and eliminate any insults that may disturb the regular behavior of the brain. As part of its defensive role, it releases pro- and anti-inflammatory cytokines that aim to modulate the inflammatory scenario at the metastatic foci. However, the long term effects that these cells may exert on the metastatic progression is not clear. One of the biggest challenges in the field is to distinguish between brain resident microglial cells and infiltrated bone-marrow derived macrophages. Part of this issue is the fact that both cell types share similar phenotypes. Current studies are based on the modulation of the immune response against cancer cells (immunotherapy). However, most of current clinical trials and newly developed drugs focus on the adaptive immune response (e.g., immune blockade check-points). Additionally, the unique structure of the central nervous system with the presence of the blood-brain barrier have hindered a significant advance in novel therapies against brain metastasis. In this manuscript, we describe current advances in characterization of tumor-associated microglia and macrophages, the importance of microglia during the anti-cancerous response, and the future direction for the development of new strategies against this complex disease. es
dc.description.sponsorship Breast Cancer Now BCN2016Nov es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Frontiers Research Foundation es
dc.relation.ispartof Frontiers in Cellular Neuroscience, 12, 414-1-414-7.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.subject Microglia es
dc.subject Macrophages es
dc.subject Brain es
dc.subject Metastasis es
dc.subject Cancer es
dc.subject Therapies es
dc.title The Multifarious Role of Microglia in Brain Metastasis es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular es
dc.relation.projectID BCN2016Nov es
dc.relation.publisherversion es
dc.identifier.doi 10.3389/fncel.2018.00414 es
idus.format.extent 7 p. es
dc.journaltitle Frontiers in Cellular Neuroscience es
dc.publication.volumen 12 es
dc.publication.initialPage 414-1 es
dc.publication.endPage 414-7 es
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