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Association between sleep-disordered breathing and breast cancer aggressiveness


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dc.creator Campos-Rodríguez, Francisco es
dc.creator Cruz-Medina, Antonio es
dc.creator Selma, María José es
dc.creator Rodríguez-de-la-Borbolla-Artacho, María es
dc.creator Sanchez-Vega, Adrian es
dc.creator Ripoll-Orts, Francisco es
dc.creator Almeida González, Carmen V. es
dc.creator Martinez-Garcia, Miguel Angel es 2019-01-16T08:59:37Z 2019-01-16T08:59:37Z 2018-11-21
dc.identifier.citation Campos-Rodríguez, F., Cruz-Medina, A., Selma, M.J., Rodríguez-de-la-Borbolla-Artacho, M., Sanchez-Vega, A., Ripoll-Orts, F.,...,Martinez-Garcia, M.A. (2018). Association between sleep-disordered breathing and breast cancer aggressiveness. PloS one, 13 (11), e0207591-1-e0207591-14.
dc.identifier.issn 1932-6203 es
dc.description.abstract Background Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness. Methods 83 consecutive women <65 years diagnosed with primary BC underwent a home respiratory polygraphy. Markers of SDB severity included the apnea-hypopnea index (AHI) and the 4% oxygen desaturation index (ODI4). The Ki67 proliferation index, lack of hormone receptors (HR-), Nottingham Histological Grade (NHG), and tumor stage were used as markers of BC aggressiveness. The association between SDB and molecular subtypes of BC was also assessed. Results The mean (SD) age was 48.8 (8.8) years and body mass index was 27.4 (5.4) Kg/m2. 42 women (50.6%) were post-menopausal. The median (IQR) AHI was 5.1 (2–9.4), and ODI4 was 1.5 (0.5–5.8). The median (IQR) AHI did not differ between the groups with Ki67>28% and Ki67<29% [5.1 (2.6–8.3) vs 5.0 (1.5–10), p = 0.89)], HR- and HR+ [5.7 (1.6–12.4) vs 4.9 (2–9.4), p = 0.68], NHG (Grade3, Grade2, and Grade1; p = 0.86), tumor stage (stage III-IV, stage II, and stage I; p = 0.62), or molecular subtypes (Luminal A, Luminal B, HER2, and triple negative; p = 0.90). The prevalence of an AHI≥5 did not differ between the groups with Ki67>28% and Ki67<29% (51.2% vs 52.3%, p = 0.90), HR- and HR+ (58.3% vs 49.1%, p = 0.47), NHG categories (p = 0.89), different tumor stages (p = 0.71), or molecular subtypes (p = 0.73). These results did not change when the ODI4 was used instead of the AHI. Conclusion Our results do not support an association between the presence or severity of SDB and BC aggressiveness. es
dc.description.sponsorship Asociación de Neumología y Cirugía Torácica del Sur (NEUMOSUR) 1/2015 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Public Library of Science es
dc.relation.ispartof PloS one, 13 (11), e0207591-1-e0207591-14.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.title Association between sleep-disordered breathing and breast cancer aggressiveness es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Instituto de Biomedicina de Sevilla (IBIS) es
dc.relation.projectID 1/2015 es
dc.relation.publisherversion es
dc.identifier.doi 10.1371/journal.pone.0207591 es
idus.format.extent 14 p. es
dc.journaltitle PloS one es
dc.publication.volumen 13 es
dc.publication.issue 11 es
dc.publication.initialPage e0207591-1 es
dc.publication.endPage e0207591-14 es
dc.contributor.funder Asociación de Neumología y Cirugía Torácica del Sur (NEUMOSUR)
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