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Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage

 

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dc.creator Pastor, María Dolores es
dc.creator Nogal, Ana es
dc.creator Molina-Pinelo, Sonia es
dc.creator Meléndez, Ricardo es
dc.creator Romero-Romero, Beatriz es
dc.creator Mediano, Maria Dolores es
dc.creator López-Campos, José L. es
dc.creator García-Carbonero, Rocío es
dc.creator Sanchez-Gastaldo, Amparo es
dc.creator Carnero Moya, Amancio es
dc.creator Paz-Ares Rodríguez, Luis es
dc.date.accessioned 2018-09-25T09:09:33Z
dc.date.available 2018-09-25T09:09:33Z
dc.date.issued 2013-02-06
dc.identifier.issn 1422-0067 es
dc.identifier.uri https://hdl.handle.net/11441/78786
dc.description.abstract Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC. Cigarette smoke causes oxidative stress and an inflammatory response in lung cells, which in turn may be involved in COPD and lung cancer development. The aim of this study was to identify differential proteomic profiles related to oxidative stress response that were potentially involved in these two pathological entities. Protein content was assessed in the bronchoalveolar lavage (BAL) of 60 patients classified in four groups: COPD, COPD and LC, LC, and control (neither COPD nor LC). Proteins were separated into spots by two dimensional polyacrylamide gel electrophoresis (2D-PAGE) and examined by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF). A total of 16 oxidative stress regulatory proteins were differentially expressed in BAL samples from LC and/or COPD patients as compared with the control group. A distinct proteomic reactive oxygen species (ROS) protein signature emerged that characterized lung cancer and COPD. In conclusion, our findings highlight the role of the oxidative stress response proteins in the pathogenic pathways of both diseases, and provide new candidate biomarkers and predictive tools for LC and COPD diagnosis. es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher MDPI AC es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Bronchoalveolar lavage es
dc.subject Lung cancer es
dc.subject Screening es
dc.subject Biomarker es
dc.subject Inflammation es
dc.subject Proteomics es
dc.subject ROS es
dc.subject Oxidative stress es
dc.title Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular es
dc.relation.publisherversion https://doi.org/10.3390/ijms14023440 es
dc.identifier.doi 10.3390/ijms14023440 es
idus.format.extent 16 p. es
dc.journaltitle International Journal of Molecular Sciences es
dc.publication.volumen 14 es
dc.publication.issue 2 es
dc.publication.initialPage 3440 es
dc.publication.endPage 3455 es
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