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European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

 

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dc.creator Schrag, Anette es
dc.creator Martino, Davide es
dc.creator Apter, Alan es
dc.creator Ball, Juliane es
dc.creator Bartolini, Erika es
dc.creator Benaroya-Milshtein, Noa es
dc.creator Buttiglione, Maura es
dc.creator Cardona, Francesco es
dc.creator Mir Rivera, Pablo es
dc.date.accessioned 2018-08-21T07:40:21Z
dc.date.available 2018-08-21T07:40:21Z
dc.date.issued 2018-07-07
dc.identifier.citation Schrag, A., Martino, D., Apter, A., Ball, J., Bartolini, E., Benaroya-Milshtein, N.,...,Mir Rivera, P. (2018). European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents. European Child and Adolescent Psychiatry
dc.identifier.issn 1018-8827 es
dc.identifier.issn 1435-165X es
dc.identifier.uri https://hdl.handle.net/11441/78188
dc.description.abstract Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive-compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3-10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3-16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host's immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders. es
dc.description.sponsorship German Research Society DFG: GZ MU 1527/3-1 es
dc.description.sponsorship German Ministry of Education and Research BMBF: 01KG1421 es
dc.description.sponsorship National Institute of Mental Health es
dc.description.sponsorship EU FP7-PEOPLE-2012-ITN No. 316978 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Springer Berlin Heidelberg es
dc.relation.ispartof European Child and Adolescent Psychiatry
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Genetics es
dc.subject Longitudinal es
dc.subject Obsessive-compulsive disorder es
dc.subject Streptococcal infection es
dc.subject Stress es
dc.subject Tourette syndrome es
dc.title European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Instituto de Biomedicina de Sevilla (IBIS) es
dc.relation.projectID DFG: GZ MU 1527/3-1 es
dc.relation.projectID BMBF: 01KG1421 es
dc.relation.projectID FP7-PEOPLE-2012-ITN No. 316978 es
dc.relation.publisherversion https://doi.org/10.1007/s00787-018-1190-4 es
dc.identifier.doi 10.1007/s00787-018-1190-4 es
idus.format.extent 19 p. es
dc.journaltitle European Child and Adolescent Psychiatry es
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