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A microscopy technique based on bio-impedance sensors


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Author: Yúfera García, Alberto
Huertas Sánchez, Gloria
Olmo Fernández, Alberto
Department: Universidad de Sevilla. Departamento de Tecnología Electrónica
Date: 2012
Published in: Procedia Engineering, 47, 1049-1052.
Document type: Article
Abstract: It is proposed a microscopy for cell culture applications based on impedance sensors. The imagined signals are measured with the Electrical Cell-Substrate Spectroscopy (ECIS) technique, by identifying the cell area. The proposed microscopy allows real-time monitoring inside the incubator, reducing the contamination risk by human manipulation. It requires specific circuits for impedance measurements, a two-dimensional sensor array (pixels), and employing electrical models to decode efficiently the measured signals. Analogue Hardware Description Language (AHDL) circuits for cell-microelectrode enables the use of geometrical and technological data into the system design flow. A study case with 8x8 sensor array is reported, illustrating the evolution and power of the proposed image acquisition.
Cite: Yúfera García, A., Huertas Sánchez, G. y Olmo Fernández, A. (2012). A microscopy technique based on bio-impedance sensors. Procedia Engineering, 47, 1049-1052.
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DOI: 10.1016/j.proeng.2012.09.330

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