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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

 

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Opened Access Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
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Author: Mena-Barragán, Teresa
García-Moreno, M. Isabel
Sevšek, Alen
Okazaki, Tetsuya
Nanba, Eiji
Higaki, Katsumi
Martin, Nathaniel I.
Pieteres, Roland J.
García-Fernández, José Manuel
Ortíz Mellet, María del Carmen
Department: Universidad de Sevilla. Departamento de Química Orgánica
Date: 2018
Published in: Molecules, 23 (4), 927-944.
Document type: Article
Abstract: A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized ...
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Cite: Mena-Barragán, T., García-Moreno, M.I., Sevšek, A., Okazaki, T., Nanba, E., Higaki, K.,...,Ortíz-Mellet, C. (2018). Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease. Molecules, 23 (4), 927-944.
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Format: PDF

URI: https://hdl.handle.net/11441/74515

DOI: 10.3390/molecules23040927

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