Repositorio de producción científica de la Universidad de Sevilla

Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin

Opened Access Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Reina, José Juan
Díaz, Irene
Nieto, Pedro M.
Campillo, Nuria Eugenia
Páez, Juan Antonio
Tabarani, Georges
Fieschi, Franck
Rojo, Javier
Fecha: 2008
Publicado en: Organic and Biomolecular Chemistry, 6 (15), 2743-2754.
Tipo de documento: Artículo
Resumen: DC-SIGN, a lectin, which presents at the surface of immature dendritic cells, constitutes nowadays a promising target for the design of new antiviral drugs. This lectin recognizes highly glycosylated proteins present at the surface of several pathogens such as HIV, Ebola virus, Candida albicans, Mycobacterium tuberculosis, etc. Understanding the binding mode of this lectin is a topic of tremendous interest and will permit a rational design of new and more selective ligands. Here, we present computational and experimental tools to study the interaction of di- and trisaccharides with DC-SIGN. Docking analysis of complexes involving mannosyl di- and trisaccharides and the carbohydrate recognition domain (CRD) of DC-SIGN have been performed. Trisaccharides Manα1,2[Manα1,6]Man 1 and Manα1,3[Manα1,6]Man 2 were synthesized from an orthogonally protected mannose as a common intermediate. Using these ligands and the soluble extracellular domain (ECD) of DC-SIGN, NMR experiments based on STD an...
[Ver más]
Cita: Reina, J.J., Díaz, I., Nieto, P.M., Campillo, N.E., Páez, J.A., Tabarani, G.,...,Rojo, J. (2008). Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin. Organic and Biomolecular Chemistry, 6 (15), 2743-2754.
Tamaño: 920.5Kb
Formato: PDF

URI: https://hdl.handle.net/11441/73498

DOI: 10.1039/b802144a

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones