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Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus

Opened Access Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus

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Autor: Pinto Pérez, Francisco M.
Pintado, C. Oscar
Pennefather, Jocelyn N.
Patak, Eva
Candenas de Luján, María Luz
Fecha: 2009
Publicado en: Reproductive Biology and Endocrinology, 7 (77)
Tipo de documento: Artículo
Resumen: Background: In the mouse uterus, pregnancy is accompanied by changes in tachykinin and tachykinin receptor gene expression and in the uterotonic effects of endogenous tachykinins. In this study we have investigated whether changes in tachykinin expression and responses are a result of changes in ovarian steroid levels. Methods: We quantified the mRNAs of tachykinins and tachykinin receptors in uteri from ovariectomized mice and studied their regulation in response to estrogen and progesterone using real-time quantitative RT-PCR. Early (3 h) and late (24 h) responses to estrogen were evaluated and the participation of the estrogen receptors (ER), ERalpha and ERbeta, was analyzed by treating mice with propylpyrazole triol, a selective ERalpha agonist, or diarylpropionitrile, a selective agonist of ERbeta. Results: All genes encoding tachykinins (Tac1, Tac2 and Tac4) and tachykinin receptors (Tacr1, Tacr2 and Tacr3) were expressed in uteri from ovariectomized mice. Estrogen in...
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Cita: Pinto Pérez, F.M., Pintado, C.O., Pennefather, J.N., Patak, E. y Candenas de Luján, M.L. (2009). Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus. Reproductive Biology and Endocrinology, 7 (77)
Tamaño: 276.5Kb
Formato: PDF

URI: https://hdl.handle.net/11441/72139

DOI: 10.1186/1477-7827-7-77

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