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Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules

Opened Access Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules

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Autor: Cuecas Morano, María de Piedras Alba
Cruces Tova, Jorge
Galisteo López, Juan Francisco
Peng, H. X.
Gonzáles Grau, Juan Miguel
Fecha: 2016-08-23
Publicado en: Biophysical Journal, 111 (4), 875-882.
Tipo de documento: Artículo
Resumen: Some low molecular weight biomolecules, i.e., NAD(P)H, are unstable at high temperatures. The use of these biomolecules by thermophilic microorganisms has been scarcely analyzed. Herein, NADH stability has been studied at different temperatures and viscosities. NADH decay increased at increasing temperatures. At increasing viscosities, NADH decay rates decreased. Thus, maintaining relatively high cellular viscosity in cells could result in increased stability of low molecular weight biomolecules (i.e., NADH) at high temperatures, unlike what was previously deduced from studies in diluted water solutions. Cellular viscosity was determined using a fluorescent molecular rotor in various prokaryotes covering the range from 10 to 100°C. Some mesophiles showed the capability of changing cellular viscosity depending on growth temperature. Thermophiles and extreme thermophiles presented a relatively high cellular viscosity, suggesting this strategy as a reasonable mechanism to thrive under th...
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Cita: Cuecas Morano, M.d.P.A., Cruces Tova, J., Galisteo López, J.F., Peng, H.X. y Gonzáles Grau, J.M. (2016). Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules. Biophysical Journal, 111 (4), 875-882.
Tamaño: 789.0Kb
Formato: PDF

URI: https://hdl.handle.net/11441/71708

DOI: 10.1016/j.bpj.2016.07.024

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