Opened Access NUMB and NUMBL differences in gene regulation

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: García Heredia, José Manuel
Carnero Moya, Amancio
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2018
Publicado en: Oncotarget, 9 (10), 9219-9234.
Tipo de documento: Artículo
Resumen: NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation of these genes in tumors is common, allowing aberrant Notch pathway activation and tumor progression. However, some known differences between NUMB and NUMBL have raised unanswered questions regarding the redundancy and/or combined regulation of the Notch pathway by these genes during the tumorigenic process. We have found that NUMB and NUMBL exhibit mutual exclusivity in human tumors, suggesting that the associated tumor suppressor role is regulated by only one of the two proteins in a specific cell, avoiding duplicate signaling and simplifying the regulatory network. We have also found differences in gene expression due to NUMB or NUMBL downregulation. These differences in gene regulation extend to pathways, such as WNT or Hedgehog. In addition to these differences, the downregulation of either gene triggers a cancer stem cell-like related phenotype. These results...
[Ver más]
Cita: García Heredia, J.M. y Carnero Moya, A. (2018). NUMB and NUMBL differences in gene regulation. Oncotarget, 9 (10), 9219-9234.
Tamaño: 7.608Mb
Formato: PDF

URI: https://hdl.handle.net/11441/71238

DOI: 10.18632/oncotarget.24186

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones