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PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis

Opened Access PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis

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Autor: Urbano, José M.
Domínguez Jiménez, Paloma
Estrada, Beatriz
Martín Bermudo, María D.
Fecha: 2011
Publicado en: PLoS One, 6 (9), e23893-.
Tipo de documento: Artículo
Resumen: During embryonic development, there are numerous cases where organ or tissue formation depends upon the migration of primordial cells. In the Drosophila embryo, the visceral mesoderm (vm) acts as a substrate for the migration of several cell populations of epithelial origin, including the endoderm, the trachea and the salivary glands. These migratory processes require both integrins and laminins. The current model is that αPS1βPS (PS1) and/or αPS3βPS (PS3) integrins are required in migrating cells, whereas αPS2βPS (PS2) integrin is required in the vm, where it performs an as yet unidentified function. Here, we show that PS1 integrins are also required for the migration over the vm of cells of mesodermal origin, the caudal visceral mesoderm (CVM). These results support a model in which PS1 might have evolved to acquire the migratory function of integrins, irrespective of the origin of the tissue. This integrin function is highly specific and its specificity resides mainly in the extrac...
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Cita: Urbano, J.M., Domínguez Jiménez, P., Estrada, B. y Martín Bermudo, M.D. (2011). PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. PLoS One, 6 (9), e23893-.
Tamaño: 3.618Mb
Formato: PDF

URI: https://hdl.handle.net/11441/71096

DOI: 10.1371/journal.pone.0023893

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